Evaluation of clinicopathological and prognostic significance of RDW in gastric cancer

Abstract

Objective: We aimed to reveal possible relationships between pre-operative RDW values and clinicopathological features of gastric cancer (GC) and to evaluate its predictive impact on progression and prognosis of GC. Material And Method: A total of 92 patients who underwent curative surgery were retrospectively included the study. GC patients were divided into two groups: high-RDW group (>14.5%, n=58) and low-RDW (<14.5%, n=34). Results: The optimal pre-operative RDW cut-off value to predict mortality in GC patients was 14.5% (AUC=0.690, p=0.010). Increased tumor size and decreased albumin and hemoglobin values were found in the high-RDW group (p=0.036, 0.003 and <0.001, respectively). The 5-year overall survival (OS) rates were 17.6±5% in patients with high-RDW and 44.5±9% in the low-RDW group (p<0.001). Cox regression analysis showed perineural invasion, surgical margin positivity, N3 stage, leakage and high RDW were independent prognostic factors for mortality. Conclusion: Our results indicate that RDW is associated with GC pathogenesis and tumor progression. Pre-operative RDW may be a non-invasive, easily accessible and reliable indicator to predict survival in patients with GC.

Keywords

• Gastric cancer
• Red cell distribution width
• RDW
• prognosis
• overall survival

RDW'nin mide kanserinde klinikopatolojik ve prognostik öneminin değerlendirilmesi

Abstract

Amaç: Preoperatif RDW değerleri ile mide kanseri (MK)’nin klinikopatolojik özellikleri arasındaki olası ilişkileri ortaya koymayı ve MK’nin progresyonu ve prognozu üzerindeki prediktif etkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: Küratif cerrahi uygulanan toplam 92 hasta retrospektif olarak çalışmaya dahil edildi. MK hastaları iki gruba ayrıldı: yüksek RDW grubu (>%14,5, n=58) ve düşük RDW (<%14,5, n=34). Bulgular: MK hastalarında mortaliteyi öngörmek için optimal preoperatif RDW eşik değeri %14,5 idi (AUC=0,690, p=0,010). Yüksek RDW grubunda tümör boyutunda artış, albümin ve hemoglobin değerlerinde azalma saptandı (sırasıyla p=0,036, 0,003 ve <0,001). Yüksek RDW’li hastalarda 5 yıllık genel sağkalım (OS) oranları %17,6±%5 ve düşük RDW grubunda %44,5±%9 idi (p<0,001). Cox regresyon analizi perinöral invazyon, cerrahi sınır pozitifliği, N3 evresi, sızıntı ve yüksek RDW değerinin mortalite için bağımsız prognostik faktörler olduğunu gösterdi. Sonuç: Sonuçlarımız, RDW’nin MK patogenezinde ve tümör progresyonunda rol oynadığını göstermektedir. Preoperatif RDW, MK’li hastalarda sağkalımı öngörmek için invazif olmayan, kolay erişilebilir ve güvenilir bir gösterge olabilir.

Keywords

• Mide kanseri
• Eritrosit dağılım genişliği
• RDW
• Prognoz
• Genel sağkalım

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