Diş hekimliğinde esansiyel yağların kullanımı

Abstract

Periodontal hastalık, mevcut oral floranın disbiyozu nedeniyle periodonsiyumun yıkımına yol açan ilerleyici, enfeksiyöz bir inflamatuvar hastalıktır. Patojenik mikroorganizmalar, periodontal hastalığın etiyolojik faktörüdür, patojene karşı gelişen immüno-inflamatuvar yanıt hastalığın ilerlemesinde rol oynar. Periodontal hastalık sırasında, reaktif oksijen türlerinin aşırı üretimi ile onları detoksifiye eden antioksidanların yetersizliği sonucu oksidatif stres meydana gelir. Oksidatif stres, periodonsiyumun yıkımına neden olmaktadır. Bu nedenle, reaktif oksijen türlerinin antagonisti olarak, antioksidanlar periodontal hastalıkların tedavisinde yardımcı olabilmektedir. Bitkiler, periodontal sağlığın korunmasında eşsiz rol oynayan bazı dikkat çekici özelliklere sahiptir. Bu özellikler geleneksel periodontal tedavinin sonuçlarını iyileştirebilecek potansiyele sahiptir. Bu derlemenin amacı, periodontal hastalıkların tedavisine potansiyel katkıları olan çeşitli esansiyel yağlar hakkında bilgi vermektir.

Keywords

• Antioksidan
• Antibakteriyel
• Esansiyel yağlar
• Periodontal hastalık

Usage of essential oils in dentistry

Abstract

Periodontal disease is a progressive, infectious inflammatory disease that leads to the destruction of the periodontium due to dysbiosis of the existing oral flora. Pathogenic microorganisms are the etiological factor of periodontal disease, the immuno-inflammatory response against the pathogen plays a role in the progression of the disease. During periodontal disease, oxidative stress occurs as a result of overproduction of reactive oxygen species and insufficiency of antioxidants that detoxify them. Oxidative stress causes destruction of the periodontium. Therefore, as antagonists of reactive oxygen species, antioxidants can help in the treatment of periodontal diseases. Plants have some remarkable properties that play a unique role in maintaining periodontal health. These properties have the potential to improve the results of traditional periodontal treatment. The purpose of this review is to provide information about various essential oils that have potential contributions to the treatment of periodontal diseases.

Keywords

• Antibacterial
• Essential oil
• Periodontal disease
• Antioxidant

References

1. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 2006; 27: 1-93.
2. Sakkas H, Papadopoulou C. Antimicrobial Activity of Basil, Oregano, and thyme essential oils. J Microbiol Biotechnol 2017; 27: 429-38.
3. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994; 5: 78–111.
4. Schwach-Abdellaoui K, Vivien-Castioni N, Gurny R. Local delivery of antimicrobial agents for the treatment of periodontal disease. Euro J Pharma Biopharm 2000; 50: 83–99.
5. Jaykumar P, Deepalakshmi P, Shankaram V. Local drug delivery using doxycycline hyclate (Microplast) in the treatment of periodontal disease: A Clinical and microbiological evaluation. Int. J Contemporary Dentistry 2011; 2: 30–6.
6. Hammer KA, Carson CF, Riley TV. Antimicrobial activity of essential oils and other plant extracts. J Appl Microbiol 1999; 86: 985-90.
7. Warad SB, Kolar SS, Kalburgi V, Kalburgi NB. Lemongrass essential oil gel as a local drug delivery agent for the treatment of periodontitis. Anc Sci Life 2013; 32: 205-11.
8. Sakkas H, Papadopoulou C. Antimicrobial activity of basil, oregano, and thyme essential oils. J Microbiol Biotechnol. 2017; 28: 429-43

9. Amini P, Araujo MW, Wu MM. Comparative antiplaque and antigingivitis efficacy of three antiseptic mouthrinses: a two week ran- domized clinical trial. Braz Oral Res 2009; 23: 319–25.
10. Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc 2006; 137:1649-57.
11. Fine DH, Markowitz K, Furgan D, et al. Effect of rinsing with an essential oil–containing mouthrinse on subgingival periodontopathogens. J Periodontol 2007; 78: 1935–42.
12. Pan P, Barnett ML, Coelho J, Brogdon C, Finnegan MB. Determination of the in situ bactericidal activity of an essential oil mouthrinse using a vital stain method. J Clin Periodontol 2000; 27: 256-61.
13. Pianotti R, Pitts G. Effects of an antiseptic mouthwash on odorigenic microbes in the human gingival crevice. J Dent Res 1978; 57: 175-9.
14. Hosamane M, Acharya AB, Vij C, Trivedi D, Setty SB, Thakur SL. Evaluation of holy basil mouthwash as an adjunctive plaque control agent in a four day plaque regrowth model. J Clin Exp Dent 2014; 6: e4916.
15. Javed F, Al-Hezaimi K, Romanos GE. Role of dentifrices with essential oil formulations in periodontal healing. Am J Med Sci. 2012; 343: 411-7.
16. Haas A, Mendes C, Andrade AK, et al. Mouthwashes for the control of supragingival biofilm and gingivitis in orthodontic patients: evidence-based recommendations for clinicians. Braz Oral Res 2014; 28: 1-8.
17. Ciancio F, Lauciello O, Shibly M. The effect of an antiseptic mouthrinse on ımplant maintenance: plaque and peri- ımplant gingival tissues. J Periodontol 1995; 66: 962-5.
18. Marinho VT, Dos Reis AC, da Costa Valente ML. Efficacy of antimicrobial agents in dentifrices: a systematic review. antibiotics (Basel) 2022; 11: 1413.
19. Khasawneh S- Al Wahadni A. Control of denture plaque and mucosal inflammation in denture wearers. J Iran Dent Assoc 2002; 48: 132–82.
20. Kurnatowska A, Bieniek J. The level of cariogenic bacteria in wearers of partial dentures. Prot Stomatol 2006; 56: 2.
21. Kanli A, Demirel F, Sezgin Y. Oral candidosis, denture cleanliness and hygiene habits in an elderly population. Aging Clin Exp Res 2005; 17: 502–7.
22. Williams D- Lewis M. Pathogenesis and treatment of oral candidosis. J. Oral Microbiol 2011; 1: 1-11.
23. Mendes L, Coimbra J, Pereira A, Resende M, Pinto M. Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study. Int J Dent Hyg 2016; 14: 202–8.
24. Akkaoui S, Johansson A, Yagoubi M, et al. Chemical composition, antimicrobial activity in vitro cytotoxicity and leukotoxin neutralization of essential oil from Origanum vulgare against Aggregatibacter actinomycetemcomitans. Pathogens 2020; 9: 192.
25. Kabra P, Loomba K, Kabra SK, Majumdar DSP, Kumar N. Medicinal plants in the treatment of dental caries. Asian J Oral Health Allied Sci 2012; 1: 13.
26. Pulikottil S-Nath S. Potential of clove of Syzygium aromaticum in development of a therapeutic agent for periodontal disease: A review. South African Dent J 2015; 70: 108-15.
27. Stay FP. Herbs in dentistry. Int Dent J 1996; 61: 287-96.
28. Zuzarte M, Gonçalves M, Cruz M, et al. Lavandula luisieri essential oil as a source of antifungal drugs. Food Chemistry 2012; 135: 1505-10.
29. Al-Harbi MM, Qureshi S, Raza M, Ahmed MM, Giangreco A, Shah AH. Anticarcinogenic effect of Commiphora molmol on solid tumors induced by Ehrlich carcinoma cells in mice. Chemotherapy 1994; 40: 337-47.
30. Elaissi A, Rouis Z, Salem NAB, et al. Chemical composition of 8 eucalyptus species’ essential oils and the evaluation of their antibacterial, antifungal and antiviral activities. BMC Complementary and Alternative Medicine 2012; 12: 1-15.
31. Serafino A, Vallebona, PS Andreola F, et al. Stimulatory effect of Eucalyptus essential oil on innate cell-mediated immune response. BMC Immunology 2008; 9: 1-16.
32. Maurice M. Hayat veren şifalı otlar. İstanbul, Milliyet Yayınları 1998.
33. Ardakani MT, Ghassemi S, Mehdizadeh M, Mojab F, Salamzadeh J, Ghassemi S, Hajifathali A. Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial. Complementary Therapies in Medicine 2016; 29: 29-34.
34. Ferreira CM, da Silva Rosa OP, Torres SA, Ferreira FB, Bernardinelli N. Activity of endodontic antibacterial agents against selected anaerobic bacteria. Braz Dent J 2002; 13: 118-22.
35. Neelakantan P, Jagannathan N, Nazar N. Ethnopharmacological approach in endodontic treatment: A focused review. Int J Drug Dev Res 2011; 3: 68-77.
36. Patri G, Sahu A. Role of herbal agents-tea tree oil and aloe vera as cavity disinfectant adjuncts in minimally invasive dentistry-an in vivo comparative study. J Clin Diagnostic Res 2017; JCDR 11: DC05.
37. Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol 2003; 18, 389–92.
38. Wiatrak K, Morawiec T, Rój R, et al. Evaluation of effectiveness of a toothpaste containing tea tree oil and ethanolic extract of propolis on the ımprovement of oral health in patients using removable partial dentures. Molecules 2021; 26: 4071.
39. Alrazhi BA, Essa SA, Ahmed G, Ezzat S, Pha D. Antibacterial activity of the ethanolic extracts of Allium sativum L. bulbs and Zingiber officinale roscoe rhizomes as irrigating solutions. World J Pharmacy Pharmaceutical Sci 2014; 3: 332.
40. Cai L, Wu CD. Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens. J Natural Products 1996; 59: 987-90.
41. Labadie C, Ginies C, Guinebretiere MH, Renard C, Cerutti C, Carlin F. Hydrosols of orange blossom (Citrus aurantium), and rose flower (Rosa damascena and Rosa centifolia) support the growth of a heterogeneous spoilage microbiota. Food Res Int 2015; 76(Pt 3): 576-86.
42. Dikmetaş DN, Konuşur G, Mutlu-İngök A, Gülsünoğlu Z, Karbancioğlu-Güler F. Portakal (Citrus sinensis) kabuğundan elde edilen hidrosol/esansiyel yağların antimikrobiyal ve antioksidan özellikleri. Düzce Üniversitesi Bilim ve Teknoloji Derg 2019; 7: 274-83.
43. Oyama KO, Siqueira EL, Santos M. In vitro study of effect of solvent on root canal retreatment. Braz Dent J 2002; 13: 208-11.
44. Taalab MR, Mahmoud SA, Moslemany RME, Abdelaziz DM. Intrapocket application of tea tree oil gel in the treatment of stage 2 periodontitis. BMC Oral Health. 2021; 21: 239.
45. Benzaid C, Belmadani A, Tichati L, Djeribi R, Rouabhia M. Effect of Citrus aurantium L. Essential Oil on Streptococcus mutans Growth, Biofilm Formation and Virulent Genes Expression. Antibiotics (Basel). 2021; 10: 54.
46. Tambur Z, Miljković-Selimović B, Opačić D, et al. Inhibitory effects of propolis and essential oils on oral bacteria. J Infect Dev Ctries. 2021;15: 1027-31.
47. Dascalu Rusu LM, Moldovan M, Sarosi C, et al. Photodynamic Therapy with Natural Photosensitizers in the Management of Periodontal Disease Induced in Rats. Gels. 2022; 8: 134.
48. Singh N, Puzhankara L, Kedlaya MN, Ramanarayanan V. Effectiveness of tea tree oil versus chlorhexidine in the treatment of periodontal diseases: a systematic review. Evid Based Dent. 2022; 10.1038/s41432-022-0259-6.
49. Nascimento ASD, Tamiasso RSS, Morais SFM, et al. Essential oils for healing and/or preventing infection of surgical wounds: a systematic review. Rev Esc Enferm USP 2022; 56: e 20210442.
50. Bertl K, Geissberger C, Zinndorf D, et al. Bacterial colonisation during regular daily use of a power-driven water flosser and risk for cross-contamination. Can it be prevented?. Clin Oral Investig 2022; 26: 1903-13.