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The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study

Year 2024, , 57 - 64, 29.02.2024
https://doi.org/10.47582/jompac.1405773

Abstract

Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio (UHR) as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction (STEMI).
Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention (PPCI) from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality (n=100) and those without in-hospital mortality (n=1265).
Results: In-hospital mortality occurred in 100 patients (7.3%). UHR was notably higher in the mortality group compared to the non-mortality group (23.6±14.9% vs. 15.3±6.9%, p<0.001). Logistic regression analysis identified several independent determinants of in-hospital mortality among STEMI patients, including age (odds ratio [OR]=1.050, p<0.001), the presence of DM (OR=2.077, p=0.016), serum glucose (OR=1.004, p=0.002), hemoglobin (OR=0.855, p=0.020), White blood cell count (OR=1.064, p=0.025), UHR (OR=1.683, p<0.001), and SYNTAX score (OR=1.099, p<0.001). Receiver operating characteristic curve analysis revealed that UHR>13.9% determined in-hospital mortality in STEMI patients who underwent PPCI with 81.1% sensitivity and 49.2% specificity (AUC=0.668, p=0.001)
Conclusion: The UHR exhibited a significant and independent positive correlation with in-hospital mortality among STEMI patients undergoing PPCI.

References

  • Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92(1):7-32.
  • Anderson JL, Morrow DA. Acute myocardial infarction. NEJM. 2017;376(21):2053-2064.
  • Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177.
  • Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2021;42(14):1289-1367.
  • Zeymer U, Ludman P, Danchin N, et al. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in Europe: the ACVC-EAPCI EORP STEMI Registry of the European Society of Cardiology. Eur Heart J. 2021;42(44):4536-4549.
  • Chuang SY, Chen JH, Yeh WT, Wu CC, Pan WH. Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort. Int J Cardiol. 2012;154(3):316-321.
  • Li L, Zhao M, Wang C, et al. Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk. Clin Res Cardiol. 2021;110(7):1096-1105.
  • Goldbourt U, Yaari S, Medalie JH. Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21-year follow-up of 8000 men. Arterioscler Thromb. 1997;17(1):107-113.
  • Yu S, Guo X, Li GX, Yang H, Zheng L, Sun Y. Lower or higher HDL-C levels are associated with cardiovascular events in the general population in rural China. Lipids Health Dis. 2020;19(1):1-6.
  • Kosekli MA, Kurtkulagii O, Kahveci G, et al. The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. Rev Assoc Med Bras. 2021;67:549-554.
  • Zhou Y, Wei F, Fan Y. High serum uric acid and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Clin Biochem. 2016;49(7-8):636-642.
  • Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras. 2019;65(1):9-15.
  • Zhang YN, Wang QQ, Chen YS, Shen C, Xu CF. Association between serum uric acid to hdl-cholesterol ratio and nonalcoholic fatty liver disease in lean chinese adults. Int J Endocrinol. 2020;2020:5953461.
  • Kurtkulagi O, Tel BMA, Kahveci G, et al. Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med. 2021;59(4):403-408.
  • Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 2020;23(5):1098-1102.
  • Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219-227.
  • Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163(19):2345-2353.
  • Stolt Steiger V, Goy JJ, Stauffer JC, et al. Significant decrease in in-hospital mortality and major adverse cardiac events in Swiss STEMI patients between 2000 and December 2007. Swiss Med Wkly. 2009;139(31-32):453-457.
  • Cretu DE, Udroiu CA, Stoicescu CI, Tatu-Chitoiu G, Vinereanu D. Predictors of in-hospital mortality of ST-segment elevation myocardial infarction patients undergoing interventional treatment. An analysis of data from the RO-STEMI registry. Maedica. 2015;10(4):295-303.
  • Gale CP, Manda S, Batin PD, Weston CF, Birkhead JS, Hall AS. Predictors of in-hospital mortality for patients admitted with ST-elevation myocardial infarction: a real-world study using the Myocardial Infarction National Audit Project (MINAP) database. Heart. 2008;94(11):1407-1412.
  • Alves L, Ziegelmann PK, Ribeiro V, Polanczyk C. Hospital mortality from myocardial infarction in Latin America and the Caribbean: systematic review and meta-analysis. Arq Bras Cardiol. 2022;119(6):970-978.
  • Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PloS One. 2013;8(10):e78206.
  • Mortada I. Hyperuricemia, type 2 diabetes mellitus, and hypertension: an emerging association. Curr Hypertens Rep. 2017; 19(9):69.
  • Cheng KH, Chu CS, Lin TH, Lee KT, Sheu SH, Lai WT. Lipid paradox in acute myocardial infarction—the association with 30-day in-hospital mortality. Crit Care Med. 2015;43(6):1255-1264.
  • Reddy VS, Bui QT, Jacobs JR, Begelman SM, Miller DP, French WJ. Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox). Am J Cardiol. 2015;115(5):557-562.
  • Ji MS, Jeong MH, Ahn YK, et al. Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction). J Cardiol. 2015;65(1):63-70.
  • Yang Y, Zhang J, Jia L, Su J, Ma M, Lin X. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction. Front Cardiovasc Med. 2023;10:1226108.
  • Hu X, Liu J, Li W, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis. Nutr Metab Cardiovasc Dis. 2022;32(7):1661-1669.
  • Mansiroglu AK, Cekici Y, Sincer I, Gunes Y. Serum uric acid and uric acid to HDL-cholesterol ratio in coronary artery fistulas. Ann Med Res. 2019;26(12):2771-2775.
  • Aydın C, Emlek N. The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion. Kardiologiia. 2021;61(9):61-65.
  • Li F, Zhao D, Li Q, Lin X, Sun H, Fan Q. Uric acid to high-density lipoprotein cholesterol ratio is a novel marker to predict functionally significant coronary artery stenosis. J Interv Cardiol. 2022;2022:9057832.
  • Rencuzogullari I, Çağdaş M, Karakoyun S, et al. Association of Syntax Score II with contrast-induced nephropathy and hemodialysis requirement in patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Korean Circ J. 2018;48(1):59-70.
  • Alıcı G, Barman HA, Atıcı A, Tuğrul S, Genç Ö, Şahin İ. The impact of lesion complexity and the CHA 2 DS 2-VASc score on spontaneous reperfusion in patients with ST-segment elevation myocardial infarction. Int J Clin Pract. 2022;2022:8066780.
  • Cirakoglu OF, Aslan AO, Akyuz AR, et al. The value of syntax score to predict new‐onset atrial fibrillation in patients with acute coronary syndrome. Ann Noninvasive Electrocardiol. 2019;24(4):e12622.
  • Kul S, Akgul O, Uyarel H, et al. High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2012;23(8):542-548.
  • Alıcı G, Genç Ö, Urgun ÖD, et al. The value of PRECISE-DAPT score and lesion complexity for predicting all-cause mortality in patients with NSTEMI. Egypt Heart J. 2023;75(1):1-7.
  • Ali M, Lange S, Wittlinger T, Lehnert G, Rigopoulos A, Noutsias M. In-hospital mortality after acute STEMI in patients undergoing primary PCI. Herz. 2018;43(8):741-745.
  • Sanguanwong S, Srimahachota S, Tungsubutra W, Srichaiveth B, Kiatchoosakun S. Predictors of in-hospital mortality in Thai STEMI patients: results from TACSR. J Med Assoc Thai. 2007;90(Suppl 1):91-97.
  • Almeida I, Miranda H, Santos H, et al. Prognostic value of BNP in STEMI patients. Eur Heart J Acute Cardiovasc Care. 2021;10(Supplement_1):zuab020-093.
  • Akgul O, Uyarel H, Pusuroglu H, et al. High BNP level as risk factor for acute kidney injury and predictor of all-cause mortality in STEMI patients. Herz. 2014;39(4):507-514.
  • Caputo RP, Goel A, Pencina M, et al. Impact of drug eluting stent length on outcomes of percutaneous coronary intervention (from the EVENT registry). Am J Cardiol. 2012;110(3):350-355.
  • Konishi H, Miyauchi K, Dohi T, et al. Impact of stent length on clinical outcomes of first-generation and new-generation drug-eluting stents. Cardiovasc Interv Ther. 2016;31(2):114-121.
  • Moghaddam N, Wong GC, Cairns JA, et al. Association of anemia with outcomes among ST-segment–elevation myocardial infarction patients receiving primary percutaneous coronary intervention. Circ Cardiovasc Interv. 2018;11(12):e007175.
  • Rousan TA, Pappy RM, Chen AY, Roe MT, Saucedo JF. Impact of diabetes mellitus on clinical characteristics, management, and in-hospital outcomes in patients with acute myocardial infarction (from the NCDR). Am J Cardiol. 2014;114(8):1136-1144.

ST yükselmeli miyokard enfarktüsünde serum ürik asit-HDL kolesterol oranının mortalitenin yeni bir belirleyicisi olarak değerlendirilmesi: kesitsel bir çalışma

Year 2024, , 57 - 64, 29.02.2024
https://doi.org/10.47582/jompac.1405773

Abstract

Giriş ve amaç: Bu çalışmanın amacı, ST-segment Yükselmeli Miyokard Enfarktüsü (STYME) geçiren hastalarda mortalite için yeni bir enflamatuar ve metabolik belirteç olarak Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranının (ÜHO) öngörücü etkinliğini değerlendirmektir.
Yöntemler: Bu retrospektif, tek merkezli, kesitsel, gözlemsel çalışmaya Mart 2021 ile Ocak 2022 tarihleri arasında primer perkütan koroner girişim (PPKG) uygulanan STYMI tanılı 1361 hasta dahil edilmiştir. Katılımcılar iki gruba ayrılmıştır: hastane-içi mortalite gerçekleşen (n=100) ve gerçekleşmeyen (n=1265).
Sonuçlar: Hastane-içi mortalite 100 hastada (%7.3) meydana gelmiştir. ÜHO, mortalite grubunda mortalite olmayan gruba kıyasla belirgin şekilde daha yüksekti (%23.6±14.9'a karşı %15.3±6.9, p<0.001). Lojistik regresyon analizi, STYMI hastaları arasında hastane-içi mortalitenin birkaç bağımsız belirleyicisi tanımlanmıştır, yaş (risk oranı [RO]=1.050, p<0.001), DM varlığı (RO=2. 077, p=0.016), serum glukozu (RO=1.004, p=0.002), hemoglobin (RO=0.855, p=0.020), beyaz kan hücresi sayısı (RO=1.064, p=0.025), ÜHO (RO=1.683, p<0.001) ve SYNTAX skoru (R0=1.099, p<0.001). Alıcı işletim karakteristik eğrisi analizi, ÜHO> %13.9' un PPKG uygulanan STYMI hastalarında hastane içi mortaliteyi %81.1 duyarlılık ve %49.2 özgüllükle belirlediğini ortaya koymuştur (EAA=0.668, p=0.001)
Sonuçlar: ÜHO, PPKGI uygulanan STYMI hastaları arasında hastane-içi mortalite ile anlamlı ve bağımsız bir pozitif korelasyon sergilemiştir.

References

  • Mathers CD, Boerma T, Ma Fat D. Global and regional causes of death. Br Med Bull. 2009;92(1):7-32.
  • Anderson JL, Morrow DA. Acute myocardial infarction. NEJM. 2017;376(21):2053-2064.
  • Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177.
  • Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2021;42(14):1289-1367.
  • Zeymer U, Ludman P, Danchin N, et al. Reperfusion therapies and in-hospital outcomes for ST-elevation myocardial infarction in Europe: the ACVC-EAPCI EORP STEMI Registry of the European Society of Cardiology. Eur Heart J. 2021;42(44):4536-4549.
  • Chuang SY, Chen JH, Yeh WT, Wu CC, Pan WH. Hyperuricemia and increased risk of ischemic heart disease in a large Chinese cohort. Int J Cardiol. 2012;154(3):316-321.
  • Li L, Zhao M, Wang C, et al. Early onset of hyperuricemia is associated with increased cardiovascular disease and mortality risk. Clin Res Cardiol. 2021;110(7):1096-1105.
  • Goldbourt U, Yaari S, Medalie JH. Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21-year follow-up of 8000 men. Arterioscler Thromb. 1997;17(1):107-113.
  • Yu S, Guo X, Li GX, Yang H, Zheng L, Sun Y. Lower or higher HDL-C levels are associated with cardiovascular events in the general population in rural China. Lipids Health Dis. 2020;19(1):1-6.
  • Kosekli MA, Kurtkulagii O, Kahveci G, et al. The association between serum uric acid to high density lipoprotein-cholesterol ratio and non-alcoholic fatty liver disease: the abund study. Rev Assoc Med Bras. 2021;67:549-554.
  • Zhou Y, Wei F, Fan Y. High serum uric acid and risk of nonalcoholic fatty liver disease: a systematic review and meta-analysis. Clin Biochem. 2016;49(7-8):636-642.
  • Kocak MZ, Aktas G, Erkus E, Sincer I, Atak B, Duman T. Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras. 2019;65(1):9-15.
  • Zhang YN, Wang QQ, Chen YS, Shen C, Xu CF. Association between serum uric acid to hdl-cholesterol ratio and nonalcoholic fatty liver disease in lean chinese adults. Int J Endocrinol. 2020;2020:5953461.
  • Kurtkulagi O, Tel BMA, Kahveci G, et al. Hashimoto’s thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med. 2021;59(4):403-408.
  • Aktas G, Kocak MZ, Bilgin S, Atak BM, Duman TT, Kurtkulagi O. Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 2020;23(5):1098-1102.
  • Sianos G, Morel MA, Kappetein AP, et al. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 2005;1(2):219-227.
  • Granger CB, Goldberg RJ, Dabbous O, et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 2003;163(19):2345-2353.
  • Stolt Steiger V, Goy JJ, Stauffer JC, et al. Significant decrease in in-hospital mortality and major adverse cardiac events in Swiss STEMI patients between 2000 and December 2007. Swiss Med Wkly. 2009;139(31-32):453-457.
  • Cretu DE, Udroiu CA, Stoicescu CI, Tatu-Chitoiu G, Vinereanu D. Predictors of in-hospital mortality of ST-segment elevation myocardial infarction patients undergoing interventional treatment. An analysis of data from the RO-STEMI registry. Maedica. 2015;10(4):295-303.
  • Gale CP, Manda S, Batin PD, Weston CF, Birkhead JS, Hall AS. Predictors of in-hospital mortality for patients admitted with ST-elevation myocardial infarction: a real-world study using the Myocardial Infarction National Audit Project (MINAP) database. Heart. 2008;94(11):1407-1412.
  • Alves L, Ziegelmann PK, Ribeiro V, Polanczyk C. Hospital mortality from myocardial infarction in Latin America and the Caribbean: systematic review and meta-analysis. Arq Bras Cardiol. 2022;119(6):970-978.
  • Xu Y, Zhu J, Gao L, et al. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PloS One. 2013;8(10):e78206.
  • Mortada I. Hyperuricemia, type 2 diabetes mellitus, and hypertension: an emerging association. Curr Hypertens Rep. 2017; 19(9):69.
  • Cheng KH, Chu CS, Lin TH, Lee KT, Sheu SH, Lai WT. Lipid paradox in acute myocardial infarction—the association with 30-day in-hospital mortality. Crit Care Med. 2015;43(6):1255-1264.
  • Reddy VS, Bui QT, Jacobs JR, Begelman SM, Miller DP, French WJ. Relationship between serum low-density lipoprotein cholesterol and in-hospital mortality following acute myocardial infarction (the lipid paradox). Am J Cardiol. 2015;115(5):557-562.
  • Ji MS, Jeong MH, Ahn YK, et al. Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction). J Cardiol. 2015;65(1):63-70.
  • Yang Y, Zhang J, Jia L, Su J, Ma M, Lin X. The interaction between uric acid and high-density lipoprotein cholesterol on the prognosis of patients with acute myocardial infarction. Front Cardiovasc Med. 2023;10:1226108.
  • Hu X, Liu J, Li W, et al. Elevated serum uric acid was associated with pre-inflammatory state and impacted the role of HDL-C on carotid atherosclerosis. Nutr Metab Cardiovasc Dis. 2022;32(7):1661-1669.
  • Mansiroglu AK, Cekici Y, Sincer I, Gunes Y. Serum uric acid and uric acid to HDL-cholesterol ratio in coronary artery fistulas. Ann Med Res. 2019;26(12):2771-2775.
  • Aydın C, Emlek N. The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion. Kardiologiia. 2021;61(9):61-65.
  • Li F, Zhao D, Li Q, Lin X, Sun H, Fan Q. Uric acid to high-density lipoprotein cholesterol ratio is a novel marker to predict functionally significant coronary artery stenosis. J Interv Cardiol. 2022;2022:9057832.
  • Rencuzogullari I, Çağdaş M, Karakoyun S, et al. Association of Syntax Score II with contrast-induced nephropathy and hemodialysis requirement in patients with ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Korean Circ J. 2018;48(1):59-70.
  • Alıcı G, Barman HA, Atıcı A, Tuğrul S, Genç Ö, Şahin İ. The impact of lesion complexity and the CHA 2 DS 2-VASc score on spontaneous reperfusion in patients with ST-segment elevation myocardial infarction. Int J Clin Pract. 2022;2022:8066780.
  • Cirakoglu OF, Aslan AO, Akyuz AR, et al. The value of syntax score to predict new‐onset atrial fibrillation in patients with acute coronary syndrome. Ann Noninvasive Electrocardiol. 2019;24(4):e12622.
  • Kul S, Akgul O, Uyarel H, et al. High SYNTAX score predicts worse in-hospital clinical outcomes in patients undergoing primary angioplasty for acute myocardial infarction. Coron Artery Dis. 2012;23(8):542-548.
  • Alıcı G, Genç Ö, Urgun ÖD, et al. The value of PRECISE-DAPT score and lesion complexity for predicting all-cause mortality in patients with NSTEMI. Egypt Heart J. 2023;75(1):1-7.
  • Ali M, Lange S, Wittlinger T, Lehnert G, Rigopoulos A, Noutsias M. In-hospital mortality after acute STEMI in patients undergoing primary PCI. Herz. 2018;43(8):741-745.
  • Sanguanwong S, Srimahachota S, Tungsubutra W, Srichaiveth B, Kiatchoosakun S. Predictors of in-hospital mortality in Thai STEMI patients: results from TACSR. J Med Assoc Thai. 2007;90(Suppl 1):91-97.
  • Almeida I, Miranda H, Santos H, et al. Prognostic value of BNP in STEMI patients. Eur Heart J Acute Cardiovasc Care. 2021;10(Supplement_1):zuab020-093.
  • Akgul O, Uyarel H, Pusuroglu H, et al. High BNP level as risk factor for acute kidney injury and predictor of all-cause mortality in STEMI patients. Herz. 2014;39(4):507-514.
  • Caputo RP, Goel A, Pencina M, et al. Impact of drug eluting stent length on outcomes of percutaneous coronary intervention (from the EVENT registry). Am J Cardiol. 2012;110(3):350-355.
  • Konishi H, Miyauchi K, Dohi T, et al. Impact of stent length on clinical outcomes of first-generation and new-generation drug-eluting stents. Cardiovasc Interv Ther. 2016;31(2):114-121.
  • Moghaddam N, Wong GC, Cairns JA, et al. Association of anemia with outcomes among ST-segment–elevation myocardial infarction patients receiving primary percutaneous coronary intervention. Circ Cardiovasc Interv. 2018;11(12):e007175.
  • Rousan TA, Pappy RM, Chen AY, Roe MT, Saucedo JF. Impact of diabetes mellitus on clinical characteristics, management, and in-hospital outcomes in patients with acute myocardial infarction (from the NCDR). Am J Cardiol. 2014;114(8):1136-1144.
There are 44 citations in total.

Details

Primary Language English
Subjects Cardiology
Journal Section Research Articles [en] Araştırma Makaleleri [tr]
Authors

Ömer Genç 0000-0002-9097-5391

Abdullah Yıldırım 0000-0002-7071-8099

Eyüp Özkan 0000-0003-0792-628X

Publication Date February 29, 2024
Submission Date December 16, 2023
Acceptance Date February 19, 2024
Published in Issue Year 2024

Cite

AMA Genç Ö, Yıldırım A, Özkan E. The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study. J Med Palliat Care / JOMPAC / Jompac. February 2024;5(1):57-64. doi:10.47582/jompac.1405773

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