The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Abstract

Aim: This study co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemia reperfusion (IR) animal experiment.

Methods: The 2 main experimental endpoints at which the EK and S scores were evaluated, were the reperfusion 60^thmin (for A & C groups) and the reperfusion 120^thmin (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration.

Results: The first preliminary study showed that Epo hardly non significantly increased the EK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955] (p-value=0.6715). The other preliminary study found that Epo did not influence the S scores (p-value=1.0000). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together.

Conclusions: Epo again hardly non significantly increased both scores for these histologic parameters at  the grade of “without lesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they were co-evaluated together.

Keywords

• Ischemia,Erythropoietin,Endosalpingeal karyorrhexis,Salpingitis,Reperfusion

Endosalpingeal karyorrhexis ve salpingitis 'nin eritropoietin etkisinin ardından ortak değerlendirilmesi

Öz

Amaç: Bu çalışma sitokin eritropoietin (EPO) uygulamasından sonra 2 atfedilen histolojik değişkenleri ortaklaşa değerlendirdi. Hesaplama, her biri endosalpingeal karyorrhexis (EK) veya salpingitis (S) bir indüklenen iskemi reperfüzyonu (IR) hayvan denemesi içinde ilgili histolojik değişken değerlendiren 2 ön çalışmanın sonuçlarını temel aldı.

Yöntemler: EK ve S puanlarının değerlendirilmesi gereken 2 ana deneysel uç noktası reperfüzyon 60 dk (A & C grupları için) ve reperfüzyon 120 dk (B & D grupları için) idi. Özel olarak, A ve B grupları ilaç olmadan işlendi, oysa C ve D EPO uygulamasından sonra işlendi. 

Bulgular: İlk ön çalışmada EPO çok önemli ölçüde anlamlı "lezyonlar olmadan" 0,0181818 [-0,0679319-+ 0,1042955] (p-değer = 0,6715) notu tarafından ek puanları artış gösterdi. Diğer ön çalışmada EPO, S puanlarını etkilemez bulundu (p-değer = 1,0000). Her iki çalışmada aynı deneysel ayarlara sahip olduğundan birlikte tahmin edilmiştir. Bu çalışma her iki değişkenin kombine tanı değerlerini birlikte değerlendirir. 

Sonuç: EPO yine de çok önemli ölçüde bu histolojik parametreler için "lezyonlar olmadan" 0,0090909 [-0,0339659-+ 0,0521478] (p-değer = 0,6715) sınıfında birlikte değerlendirildiğinde her iki skoru artmıştır.

Anahtar Kelimeler

• İskemi,Eritropoietin,Endosalpingeal karyorrhexis,Salpenjit,Reperfüzyon

References

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