The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury

Yıl 2018, , 65 - 68, 01.05.2018

Tsompos Constantinos , Panoulis Constantinos Toutouzas Konstantinos Triantafyllou Aggeliki C. Zografos George Papalois Apostolos Kalliopi Tsarea Maria Karamperi

https://doi.org/10.28982/josam.400277

Öz

Aim: This study
co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2
preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemia
reperfusion (IR) animal experiment.

Methods: The 2 main experimental endpoints at which the EK
and S scores were evaluated, were the
reperfusion 60^thmin
(for A & C groups) and the
reperfusion 120^thmin (for B & D groups). Specially, the groups A and B were
processed without drugs, whereas the groups C
and
D after Epo administration.

Results: The
first preliminary study showed that Epo hardly non significantly increased the
EK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955]
(p-value=0.6715). The other preliminary study found that Epo did not influence the
S scores (p-value=1.0000). Both studies were co-estimated since they belong to
the same experimental setting. This study co-evaluated the combined diagnostic
values of both variables together.

Conclusions: Epo
again hardly non significantly increased both scores for these histologic
parameters at  the grade of “without
lesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they were
co-evaluated together.

Anahtar Kelimeler

Ischemia, Erythropoietin, Endosalpingeal karyorrhexis, Salpingitis, Reperfusion

Endosalpingeal karyorrhexis ve salpingitis 'nin eritropoietin etkisinin ardından ortak değerlendirilmesi

Öz

Amaç: Bu çalışma sitokin eritropoietin (EPO) uygulamasından sonra 2 atfedilen histolojik değişkenleri ortaklaşa değerlendirdi. Hesaplama, her biri endosalpingeal karyorrhexis (EK) veya salpingitis (S) bir indüklenen iskemi reperfüzyonu (IR) hayvan denemesi içinde ilgili histolojik değişken değerlendiren 2 ön çalışmanın sonuçlarını temel aldı.

Yöntemler: EK ve S puanlarının değerlendirilmesi gereken 2 ana deneysel uç noktası reperfüzyon 60 dk (A & C grupları için) ve reperfüzyon 120 dk (B & D grupları için) idi. Özel olarak, A ve B grupları ilaç olmadan işlendi, oysa C ve D EPO uygulamasından sonra işlendi. 

Bulgular: İlk ön çalışmada EPO çok önemli ölçüde anlamlı "lezyonlar olmadan" 0,0181818 [-0,0679319-+ 0,1042955] (p-değer = 0,6715) notu tarafından ek puanları artış gösterdi. Diğer ön çalışmada EPO, S puanlarını etkilemez bulundu (p-değer = 1,0000). Her iki çalışmada aynı deneysel ayarlara sahip olduğundan birlikte tahmin edilmiştir. Bu çalışma her iki değişkenin kombine tanı değerlerini birlikte değerlendirir. 

Sonuç: EPO yine de çok önemli ölçüde bu histolojik parametreler için "lezyonlar olmadan" 0,0090909 [-0,0339659-+ 0,0521478] (p-değer = 0,6715) sınıfında birlikte değerlendirildiğinde her iki skoru artmıştır.

Anahtar Kelimeler

İskemi, Eritropoietin, Endosalpingeal karyorrhexis, Salpenjit, Reperfüzyon

Kaynakça

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