A rare cause of precocious puberty: Juvenile granulosa cell tumor

Abstract

Ovarian sex cord-stromal tumors, including granulosa cell tumors are rare, especially in children. They are classified into juvenile and adult types. Juvenile granulosa cell tumors (JGCT) comprise 5% of all granulosa cell tumors. Precocious pseudo-puberty is a common presentation of these tumors, associated with hormonal changes. We report a rare case of JGCT of the ovary in a 4-year-old girl who presented with breast enlargement and alveolar pigmentation for two months. At her examination she had also an abdominal mass. Based on imagining features and laboratory findings, the diagnosis of the mass was unclear. After surgery, histopathological examination revealed JGCT of the left ovary. Although in most of girls with precocious puberty, the etiology is idiopathic, important causes, such as ovarian tumors like JGCTs must be considered.

Keywords

• Juvenile granulosa cell tumor,Ovary,Puberty

Puberte prekoksun nadir bir nedeni: Juvenil granüloza hücreli tümör

Öz

Granüloza hücreli tümörleri içeren over seks kord stromal tümörleri, özellikle çocuklarda nadir görülen tümörlerdir. Juvenil ve yetişkin tip olarak iki gruba ayrılırlar. Juvenil granüloza hücreli tümörler (JGHT) tüm granüloza hücreli tümörlerin % 5’ini içerir. Yalancı puberte prekoks, hormonal değişiklikler ile ilişkili bu tümörlerin en sık görülen bulgusudur. Biz burada 2 aydır meme büyümesi ve alveoler pigmentasyon şikayeti ile başvuran, 4 yaşındaki bir kız çocuğunda görülen nadir bir JGHT olgusunu bildirdik. Muayenesinde abdominal kitlesi de mevcuttu. Görüntüleme ve laboratuvar bulguları ile kitlenin tanısı belirsizdi. Operasyon sonrası histopatolojik tanı sol overin JGHT’ ü olarak konuldu. Puberte prekoksu olan kızların çoğunda etyoloji idiyopatik olsa da JGHT de içeren bazı over tümörleri gibi önemli nedenler göz önünde bulundurulmalıdır.

Anahtar Kelimeler

• Juvenil granüloza hücreli tümör,Over,Puberte

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