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Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient

Year 2018, Volume: 2 Issue: 3, 339 - 341, 01.09.2018
https://doi.org/10.28982/josam.412354

Abstract

Oral hairy leukoplakia (OHL), first described in 1984, is an Epstein-Barr virus lesion located laterally in the tongue and manifesting as a white, asymptomatic mucosal plaque which cannot be removed by scraping. OHL is more commonly observed in HIV-positive patients, in immunosuppressed patients after kidney, heart, liver and bone marrow transplantation, in hematological malignancies such as multiple myeloma, and in patients undergoing systemic or topical steroid therapy. OHL has rarely been reported in healthy patients who are not immunosuppressive. The case of an otherwise healthy, HIV-negative 24 year-old woman with OHL lesions in the buccal mucosa is presented here because of its rarity.

References

  • 1. Greenspan D, Greenspan JS, Conant M, et al. Oral “hairy” leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet. 1984;2:831-4.
  • 2. Piperi E, Omlie J, Koutlas IG, Pambuccian S. Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. Int J Surg Pathol. 2010;18:177-83.
  • 3. Bravo IM, Correnti M, Escalona L, et al. Prevalence of oral lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population. Med Oral Patol Oral Cir Bucal. 2006;11:E33-E39.
  • 4. Prasad JL, Bilodeau EA. Oral hairy leukoplakia in patients without HIV: presentation of 2 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e151-60.
  • 5. Felix DH, Watret K, Wray D, Southam JC. Hairy leukoplakia in an HIV-negative, nonimmunosuppressed patient. Oral Surg Oral Med Oral Pathol. 1992;74:563-6.
  • 6. Ficarra G, Romagnoli P, Piluso S, et al. Hairy leukoplakia with involvement of the buccal mucosa. J Am Acad Dermatol. 1992;27:855-8.
  • 7. Hall LD, Eminger LA, Hesterman KS, Heymann WR. Epstein-Barr virus: dermatologic associations and implications: part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders. J Am Acad Dermatol. 2015;72:1-19.
  • 8. Scully C, Porter SR, Di Alberti L, et al. Detection of Epstein-Barr virus in oral scrapes in HIV-infection, in hairy leukoplakia, and in healthy non-HIV-infected people. J Oral Pathol Med. 1998;27:480-2.
  • 9. Walling DM, Flaitz CM, Nichols CM. Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovir. J Infect Dis. 2003;188:883-90.
  • 10. Moura MD, Guimar~aes TR, Fonseca LM, et al. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:64-71.
  • 11. Schöfer H, Ochsendorf FR, Helm EB, Milbradt R. Treatment of oral ‘hairy’ leukoplakia in AIDS patients with vitamin A acid (topically) or acyclovir (systemically). Dermatologica. 1987;174:150-1.
  • 12. Bhandarkar SS, MacKelfresh J, Fried L, Arbiser JL. Targeted therapy of oral hairy leukoplakia with gentian violet. J Am Acad Dermatol. 2008;58:711-2.
  • 13. Goh BT, Lau RK. Treatment of AIDS-associated oral hairy leukoplakia with cryotherapy. Int J STD AIDS. 1994;5:60-2.

Sağlıklı, HIV negatif bir hastada bukkal mukozada oral kıllı lökoplaki

Year 2018, Volume: 2 Issue: 3, 339 - 341, 01.09.2018
https://doi.org/10.28982/josam.412354

Abstract

İlk olarak 1984'te tanımlanan oral kıllı lökoplaki (OKL), sıklıkla dil lateralde yerleşen kazımakla çıkarılamayan beyaz renkli, asemptomatik mukozal plak olarak kendini gösteren bir Epstein-Barr virüsü lezyonudur. OKL daha çok HIV pozitif hastalarda bulunurken, böbrek, kalp, karaciğer ve kemik iliği transplantasyonu sonrası immünsüpresif hastalarda, multipl miyelom gibi hematolojik malignitelerde ve sistemik veya topikal steroid tedavisi altındaki hastalarda da tanımlanmıştır. Literatürde OKL, nadiren immünsüpresif olmayan sağlıklı hastalarda da bildirilmiştir. Burada,  24 yaşında diğer açılardan sağlıklı, HIV negatif, bukkal mukozada OKL lezyonu olan kadın hasta nadir görülmesi nedeniyle sunulmaktadır.

References

  • 1. Greenspan D, Greenspan JS, Conant M, et al. Oral “hairy” leukoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet. 1984;2:831-4.
  • 2. Piperi E, Omlie J, Koutlas IG, Pambuccian S. Oral hairy leukoplakia in HIV-negative patients: report of 10 cases. Int J Surg Pathol. 2010;18:177-83.
  • 3. Bravo IM, Correnti M, Escalona L, et al. Prevalence of oral lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population. Med Oral Patol Oral Cir Bucal. 2006;11:E33-E39.
  • 4. Prasad JL, Bilodeau EA. Oral hairy leukoplakia in patients without HIV: presentation of 2 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e151-60.
  • 5. Felix DH, Watret K, Wray D, Southam JC. Hairy leukoplakia in an HIV-negative, nonimmunosuppressed patient. Oral Surg Oral Med Oral Pathol. 1992;74:563-6.
  • 6. Ficarra G, Romagnoli P, Piluso S, et al. Hairy leukoplakia with involvement of the buccal mucosa. J Am Acad Dermatol. 1992;27:855-8.
  • 7. Hall LD, Eminger LA, Hesterman KS, Heymann WR. Epstein-Barr virus: dermatologic associations and implications: part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders. J Am Acad Dermatol. 2015;72:1-19.
  • 8. Scully C, Porter SR, Di Alberti L, et al. Detection of Epstein-Barr virus in oral scrapes in HIV-infection, in hairy leukoplakia, and in healthy non-HIV-infected people. J Oral Pathol Med. 1998;27:480-2.
  • 9. Walling DM, Flaitz CM, Nichols CM. Epstein-Barr virus replication in oral hairy leukoplakia: response, persistence, and resistance to treatment with valacyclovir. J Infect Dis. 2003;188:883-90.
  • 10. Moura MD, Guimar~aes TR, Fonseca LM, et al. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:64-71.
  • 11. Schöfer H, Ochsendorf FR, Helm EB, Milbradt R. Treatment of oral ‘hairy’ leukoplakia in AIDS patients with vitamin A acid (topically) or acyclovir (systemically). Dermatologica. 1987;174:150-1.
  • 12. Bhandarkar SS, MacKelfresh J, Fried L, Arbiser JL. Targeted therapy of oral hairy leukoplakia with gentian violet. J Am Acad Dermatol. 2008;58:711-2.
  • 13. Goh BT, Lau RK. Treatment of AIDS-associated oral hairy leukoplakia with cryotherapy. Int J STD AIDS. 1994;5:60-2.
There are 13 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case report
Authors

Gülhan Gürel 0000-0001-5716-8750

Sevinç Şahin

Betül Aytekin This is me

Emine Çölgecen

Publication Date September 1, 2018
Published in Issue Year 2018 Volume: 2 Issue: 3

Cite

APA Gürel, G., Şahin, S., Aytekin, B., Çölgecen, E. (2018). Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient. Journal of Surgery and Medicine, 2(3), 339-341. https://doi.org/10.28982/josam.412354
AMA Gürel G, Şahin S, Aytekin B, Çölgecen E. Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient. J Surg Med. September 2018;2(3):339-341. doi:10.28982/josam.412354
Chicago Gürel, Gülhan, Sevinç Şahin, Betül Aytekin, and Emine Çölgecen. “Oral Hairy Leukoplakia in the Buccal Mucosa of a Healthy, HIV-Negative Patient”. Journal of Surgery and Medicine 2, no. 3 (September 2018): 339-41. https://doi.org/10.28982/josam.412354.
EndNote Gürel G, Şahin S, Aytekin B, Çölgecen E (September 1, 2018) Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient. Journal of Surgery and Medicine 2 3 339–341.
IEEE G. Gürel, S. Şahin, B. Aytekin, and E. Çölgecen, “Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient”, J Surg Med, vol. 2, no. 3, pp. 339–341, 2018, doi: 10.28982/josam.412354.
ISNAD Gürel, Gülhan et al. “Oral Hairy Leukoplakia in the Buccal Mucosa of a Healthy, HIV-Negative Patient”. Journal of Surgery and Medicine 2/3 (September 2018), 339-341. https://doi.org/10.28982/josam.412354.
JAMA Gürel G, Şahin S, Aytekin B, Çölgecen E. Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient. J Surg Med. 2018;2:339–341.
MLA Gürel, Gülhan et al. “Oral Hairy Leukoplakia in the Buccal Mucosa of a Healthy, HIV-Negative Patient”. Journal of Surgery and Medicine, vol. 2, no. 3, 2018, pp. 339-41, doi:10.28982/josam.412354.
Vancouver Gürel G, Şahin S, Aytekin B, Çölgecen E. Oral hairy leukoplakia in the buccal mucosa of a healthy, HIV-negative patient. J Surg Med. 2018;2(3):339-41.