Case Report
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Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report

Year 2019, Volume: 3 Issue: 1, 105 - 108, 27.01.2019
https://doi.org/10.28982/josam.456705

Abstract

Paragangliomas are rare tumors arising from undifferentiated cells of the primitive neural crest. We report a case of a 33-year-old female patient who presented a large firm retroperitoneal tumor situated on the left flank above the left kidney. Levels of the serum epinephrine and norepinephrine were high. We performed a scanned biopsy; the histopathological examination and the immunohistochemical analyses concluded the diagnosis of a retroperitoneal paraganglioma. The tumor was judged secreting and inoperable; therefore it was decided to be treated with radiotherapy.

References

  • 1. Lack EE, Cubilla AL, Woodruff JM, Lieberman PH. Extra-adrenal paragangliomas of the retroperitoneum. A clinicopathological study of 12 tumors. Am J Surg Pathol. 1980;4:109–20.
  • 2. Sclafani LM, Woodruff JM, Brennan MF. Extraadrenal retroperitoneal paragangliomas: natural history and response to treatment. Surgery. 1990;108:1124–9.
  • 3. Razakaboay M, Maillefert JF, Wendling D, et al. Bone metastases from a paraganglioma. A review of five cases. Rev Rheum Engl Ed. 1999;66:86–91.
  • 4. Karaçetin D, Halefoğlu A, Kabukçuoğlu F, Tatar Z. Retroperitoneal Paraganglioma: Case Presentation. Istanbul Med J. 2010;11(3):137-41.
  • 5. Rajiah P, Sinha R, Cuevas C, et al. Imaging of Uncommon Retroperitoneal Masses, Gastrointestinal Imaging; RadioGraphics. 2011;31:949–76.
  • 6. Nishino M, Hayakawa K, Minami M, Yamamoto A, Ueda H, Takasu K. Primary retroperitoneal neoplasms: CT and MRI imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 2003;23(1):45–57.
  • 7. Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23(1):29–43.
  • 8. Yang JH, Bae SJ, Park S, et al. Bilateral pheochromocytoma associated with paraganglioma and papillary thyroid carcinoma: report of an unusual case. Endocrine Journal. 2007;54(2):227–31.
  • 9. Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocrine Reviews. 2004;25(3):458–511.
  • 10. Rouaix-Emery N, Tierny-Fontalirand C, Cardot-Bauters C, Carnaille B, Wemeau J, d’Herbomez M. Le diagnostic biologique de phéochromocytome En. Ann Biol Clin. 2014;72(1) :7-13.
  • 11. Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocrine Reviews. 2004;25(3):458–511.
  • 12. Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23(1):29–43.
  • 13. Tonyukuk V, Emral R, Temiskan S, et al. “Patient with multiple paraganglioma treated with long acting somatostatin analogue,” Endocrine Journal, vol. 50, no. 5, pp. 507–513, 2003.
  • 14. Somasundar P, Krouse R, Hostetter R, et al. Paragangliomas—a decade of clinical experience. Journal of Surgical Oncology. 2000;74(4):286–90.
  • 15. Bryant RL, Stevenson DR, Hunton DW, et al. Primary malignant retroperitoneal tumors. Current management. Am J Surg. 1982;144:646-9.
  • 16. Mikhail RA, Moore JB, Reed DN Jr, et al. Malignant retroperitoneal paragangliomas. J Surg Oncol. 1986;32:32-6.
  • 17. Sclafani LM, Woodruff JM, Brennan MF. Extraadrenal retroperitoneal paragangliomas: natural history and response to treatment. Surgery. 1990;108:1124-9.
  • 18. Gannana E, van Veenendaal P, Scarlett A, Ng M. Retroperitoneal non-functioning paraganglioma: A difficult tumour to diagnose and treat. International Journal of Surgery Case Reports. 2015;17:133–5.
  • 19. Krych AJ, Foote RL, Brown PD, Garces Y, Link MJ. Long-term results of irradiation for paraganglioma. Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1063-6.

Radyoterapi ile tedavi edilen malign retroperitoneal paraganglioma: Olgu sunumu

Year 2019, Volume: 3 Issue: 1, 105 - 108, 27.01.2019
https://doi.org/10.28982/josam.456705

Abstract

Paragangliomalar, ilkel nöral krest'in farklılaşmamış hücrelerinden kaynaklanan nadir tümörlerdir. Sol böbreğin sol böbrek üzerinde yer alan geniş retroperitonal tümör hastası olan 33 yaşında bir kadın hastayı sunduk. Serum epinefrin ve norepinefrin düzeyleri yüksek bulundu. Taranmış bir biyopsi yaptık; Histopatolojik inceleme ve immunohistokimyasal analizler retroperitoneal paraganglioma tanısını koydu. Tümör salgılanıp inoperabl olarak değerlendirildi; Bu nedenle radyoterapi ile tedavi edilmeye karar verildi.

References

  • 1. Lack EE, Cubilla AL, Woodruff JM, Lieberman PH. Extra-adrenal paragangliomas of the retroperitoneum. A clinicopathological study of 12 tumors. Am J Surg Pathol. 1980;4:109–20.
  • 2. Sclafani LM, Woodruff JM, Brennan MF. Extraadrenal retroperitoneal paragangliomas: natural history and response to treatment. Surgery. 1990;108:1124–9.
  • 3. Razakaboay M, Maillefert JF, Wendling D, et al. Bone metastases from a paraganglioma. A review of five cases. Rev Rheum Engl Ed. 1999;66:86–91.
  • 4. Karaçetin D, Halefoğlu A, Kabukçuoğlu F, Tatar Z. Retroperitoneal Paraganglioma: Case Presentation. Istanbul Med J. 2010;11(3):137-41.
  • 5. Rajiah P, Sinha R, Cuevas C, et al. Imaging of Uncommon Retroperitoneal Masses, Gastrointestinal Imaging; RadioGraphics. 2011;31:949–76.
  • 6. Nishino M, Hayakawa K, Minami M, Yamamoto A, Ueda H, Takasu K. Primary retroperitoneal neoplasms: CT and MRI imaging findings with anatomic and pathologic diagnostic clues. Radiographics. 2003;23(1):45–57.
  • 7. Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23(1):29–43.
  • 8. Yang JH, Bae SJ, Park S, et al. Bilateral pheochromocytoma associated with paraganglioma and papillary thyroid carcinoma: report of an unusual case. Endocrine Journal. 2007;54(2):227–31.
  • 9. Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocrine Reviews. 2004;25(3):458–511.
  • 10. Rouaix-Emery N, Tierny-Fontalirand C, Cardot-Bauters C, Carnaille B, Wemeau J, d’Herbomez M. Le diagnostic biologique de phéochromocytome En. Ann Biol Clin. 2014;72(1) :7-13.
  • 11. Kaltsas GA, Besser GM, Grossman AB. The diagnosis and medical management of advanced neuroendocrine tumors. Endocrine Reviews. 2004;25(3):458–511.
  • 12. Rha SE, Byun JY, Jung SE, Chun HJ, Lee HG, Lee JM. Neurogenic tumors in the abdomen: tumor types and imaging characteristics. Radiographics. 2003;23(1):29–43.
  • 13. Tonyukuk V, Emral R, Temiskan S, et al. “Patient with multiple paraganglioma treated with long acting somatostatin analogue,” Endocrine Journal, vol. 50, no. 5, pp. 507–513, 2003.
  • 14. Somasundar P, Krouse R, Hostetter R, et al. Paragangliomas—a decade of clinical experience. Journal of Surgical Oncology. 2000;74(4):286–90.
  • 15. Bryant RL, Stevenson DR, Hunton DW, et al. Primary malignant retroperitoneal tumors. Current management. Am J Surg. 1982;144:646-9.
  • 16. Mikhail RA, Moore JB, Reed DN Jr, et al. Malignant retroperitoneal paragangliomas. J Surg Oncol. 1986;32:32-6.
  • 17. Sclafani LM, Woodruff JM, Brennan MF. Extraadrenal retroperitoneal paragangliomas: natural history and response to treatment. Surgery. 1990;108:1124-9.
  • 18. Gannana E, van Veenendaal P, Scarlett A, Ng M. Retroperitoneal non-functioning paraganglioma: A difficult tumour to diagnose and treat. International Journal of Surgery Case Reports. 2015;17:133–5.
  • 19. Krych AJ, Foote RL, Brown PD, Garces Y, Link MJ. Long-term results of irradiation for paraganglioma. Int J Radiat Oncol Biol Phys. 2006 Jul 15;65(4):1063-6.
There are 19 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case report
Authors

Sanae Ghammad 0000-0002-7940-8396

Ghita Chebihi Hassani This is me 0000-0003-2714-1957

Fadwa Allouche 0000-0002-6793-4911

Zineb Alami This is me 0000-0003-3349-1793

Touria Bouhafa This is me 0000-0002-6793-4911

Khalid Hassouni This is me 0000-0002-1442-255X

Publication Date January 27, 2019
Published in Issue Year 2019 Volume: 3 Issue: 1

Cite

APA Ghammad, S., Chebihi Hassani, G., Allouche, F., Alami, Z., et al. (2019). Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report. Journal of Surgery and Medicine, 3(1), 105-108. https://doi.org/10.28982/josam.456705
AMA Ghammad S, Chebihi Hassani G, Allouche F, Alami Z, Bouhafa T, Hassouni K. Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report. J Surg Med. January 2019;3(1):105-108. doi:10.28982/josam.456705
Chicago Ghammad, Sanae, Ghita Chebihi Hassani, Fadwa Allouche, Zineb Alami, Touria Bouhafa, and Khalid Hassouni. “Malignant Retroperitoneal Paraganglioma Treated With Radiotherapy: A Case Report”. Journal of Surgery and Medicine 3, no. 1 (January 2019): 105-8. https://doi.org/10.28982/josam.456705.
EndNote Ghammad S, Chebihi Hassani G, Allouche F, Alami Z, Bouhafa T, Hassouni K (January 1, 2019) Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report. Journal of Surgery and Medicine 3 1 105–108.
IEEE S. Ghammad, G. Chebihi Hassani, F. Allouche, Z. Alami, T. Bouhafa, and K. Hassouni, “Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report”, J Surg Med, vol. 3, no. 1, pp. 105–108, 2019, doi: 10.28982/josam.456705.
ISNAD Ghammad, Sanae et al. “Malignant Retroperitoneal Paraganglioma Treated With Radiotherapy: A Case Report”. Journal of Surgery and Medicine 3/1 (January 2019), 105-108. https://doi.org/10.28982/josam.456705.
JAMA Ghammad S, Chebihi Hassani G, Allouche F, Alami Z, Bouhafa T, Hassouni K. Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report. J Surg Med. 2019;3:105–108.
MLA Ghammad, Sanae et al. “Malignant Retroperitoneal Paraganglioma Treated With Radiotherapy: A Case Report”. Journal of Surgery and Medicine, vol. 3, no. 1, 2019, pp. 105-8, doi:10.28982/josam.456705.
Vancouver Ghammad S, Chebihi Hassani G, Allouche F, Alami Z, Bouhafa T, Hassouni K. Malignant retroperitoneal paraganglioma treated with radiotherapy: A case report. J Surg Med. 2019;3(1):105-8.