Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis

Engin Akgül; Mesut Engin; Ahmet Fatih Özyazıcıoğlu

doi:10.28982/josam.569158

Research Article

Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis

Year 2019, Volume: 3 Issue: 9, 663 - 665, 01.09.2019

Engin Akgül , Mesut Engin , Ahmet Fatih Özyazıcıoğlu

https://doi.org/10.28982/josam.569158

Cited By: 6

Abstract

Aim: Thrombocytes play a key role in atherosclerosis and acute vascular events. The purpose of this study is to investigate the association between mean platelet volume (MPV), platelet counts as well as other hematological parameters and biodegradable stent re-stenosis.

Methods: 53 patients who underwent percutaneous biodegradable peripheral stent placement procedure were included in this retrospective cohort study. Blood samples were collected a day before the operation. Patients were followed for a mean of 6 months and Doppler ultrasonography (DUSG) was performed for control examination. According to the DUSG results, patients were divided into two groups: Group 1 included patients with ≥50% in-stent re-stenosis and Group 2, with <50% in-stent re-stenosis.

Results: The mean age of the patients was 58.1 (6.7) years. 6 (11.3%) patients were female and 47 (88.7%) patients were male. Eight (15%) had iliac artery and 45 (84.9%) had superficial femoral artery stenosis. Doppler US reports showed that 11 (20.8%) patients had ≥50% in-stent re-stenosis (Group 1). Re-stenosis rates were higher at younger ages (P=0.020). There was no statistically difference between the groups in terms of gender (P=0.636), MPV (P=0.210), PLT counts (P=0.129) or any other hematologic parameters.

Conclusion: Several studies have shown that some blood parameters, especially MPV, are effective on coronary and peripheral stent stenosis. In our study, we found that none of the hematologic or common blood parameters can predict biodegradable stents re-stenosis.

Keywords

Biodegradable stent, Peripheral arterial disease, Platelet counts, Mean platelet volume

References

1. Karabay Ö, Karaçelik M, Yılık L, Tekin L, İriz A, Kumdereli S, et al Ischemic peripheral arterial disease: A screening survey. Turk Gogus Kalp Dama. 2012;20(3):450-7. DOI: 10.5606/tgkdc.dergisi.2012.089
2. David B, Edward W, Chrisopher T, A New Wave in Treatment of Vascular Occlusive Desease: Biodegradable Stents- Clinical experience and Scientific Principles. JVIR. 2009; 20(3):315-24. DOI: 10.1016/j.jvir.2008.11.007
3. Eren R, Doğu MH, Koç A, Altındal Ş, Yokuş O, Suyanı E. The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study. J Surg Med. 2019;3(2):176-9. DOI: 10.28982/josam.525751
4. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52 DOI: 10.28982/josam.530098
5. Werner M, Schmidt A, Scheinert S, Banning-Eichenseer U, Ulrich M, Bausback Y, et al. Evaluation of the Biodegradable Igaki-Tamai Scaffold After Drug-Eluting Balloon Treatment of De Novo Superficial Femoral Artery Lesions: The GAIA-DEB Study. J Endovasc Ther. 2016;23(1):92-7. DOI: 10.1177/1526602815620618
6. Onuma Y, Serruys PW. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization? Circulation. 2011;123(7):779-97. DOI: 10.1161/CIRCULATIONAHA.110.971606
7. Nishio S, Kosuga K, Igaki K, Okada M, Kyo E, Tsuji T, et al. Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents. Circulation. 2012;15:125(19):2343-53. DOI: 10.1161/CIRCULATIONAHA.110.000901
8. Werner M, Micari A, Cioppa A, Vadalà G, Schmidt A, Sievert H, et al Evaluation of the biodegradable peripheral Igaki-Tamai stent in the treatment of de novo lesions in the superficial femoral artery: the GAIA study JACC. Cardiovasc Interv. 2014;7(3):305-12. DOI: 10.1016/j.jcin.2013.09.009
9. Sansanayudh N, Muntham D, Yamwong S, Sritara P, Akrawichien T, Thakkinstian A. The Association between mean platelet volume and cardiovascular risk factors. Eur J Intern Med. 2016;30(5):37-42. DOI: 10.1016/j.ejim.2015.11.028
10. Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res. 2006;117(4):371-7. DOI: 10.1016/j.thromres.2005.04.004
11. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Athersclerosis. 2010;213(2):586-91. DOI: 10.1016/j.atherosclerosis.2010.09.010
12. Li S, Wang C, Zhong XW, Li HQ, FUXQ, Ran XW. Variance of mean platelet volume in subjects with normal glucose tolerance, impaired glucose regulation and type 2 diabetic mellitus and its relationship with diabetic peripheral artery disease. Zhonghua Yi Xue Za Zhi. 2012;92(2):232-5. PMID:22490792
13. Karauzum K, Bildirici U, Dervis E, Karauzum I, Baydemir C. Preprocedural Mean Platelet Volume Level Is a Predictor of In-Stent re-stenosis of the superficial femoral Artery Stents in Follow-Up. Cardiol Res Pract. 2018:4572629. DOI: 10.1155/2018/4572629
14. Dai Z, Gao J, Li S, Li R, Chen Z Mean Platelet Volume as a Predictor for Restenosis After Carotid Angioplasty and Stenting. Stroke. 2018;49(4):872-6. DOI: 10.1161/STROKEAHA.117.019748
15. Chan YC, Cheng SW, Cheung GC Predictors of restenosis in the use of helical interwoven nitinol stents to treat femoropopliteal occlusive disease. J Vasc Surg. 2015;62(5):1201-9. DOI: 10.1016/j.jvs.2015.05.030
16. Miller AJ, Takahashi EA, Harmsen WS, Mara KC, Misra S Treatment of Superficial Femoral Artery Restenosis. J Vasc Interv Radiol. 2017;28(12):1681-6. DOI: 10.1016/j.jvir.2017.07.032

Periferik biyoeriyebilir stent restenozu üzerine ortalama trombosit hacminin ve trombosit sayımının etkisi

Year 2019, Volume: 3 Issue: 9, 663 - 665, 01.09.2019

Engin Akgül , Mesut Engin , Ahmet Fatih Özyazıcıoğlu

https://doi.org/10.28982/josam.569158

Cited By: 6

Abstract

Amaç: Trombositlerin ateroskleroz ve akut vasküler olaylarda önemli bir rolü vardır. Bu çalışmanın amacı, ortalama trombosit hacmi (MPV), trombosit sayıları ve diğer hematolojik parametreler ile biyoeriyebilir stent stenozu arasında bir ilişki olup olmadığını araştırmaktır.

Yöntemler: Bu retrospektif kohort çalışmaya biyoeriyebilir periferik stentlerle perkütan müdahale yapılan 53 hasta dahil edildi. Kan örnekleri operasyondan bir gün önce alındı. Hastalar ortalama 6 ay takip edildi ve tüm hastalara kontrol amaçlı Doppler ultrasonografi (DUSG) yapıldı. Doppler ultrasonografi sonuçlarına göre hastalar iki gruba ayrıldı: Grup 1’deki hastalarda ≥%50 stentiçi restenoz ve Grup 2’deki hastalarda <%50 stentiçi restenoz mevcuttu.

Bulgular: Hastaların yaş ortalaması 58,1 (6,7) yıl olup, 6 (%11,3) hasta kadın, 47 (%88,7) hasta erkekti. Sekiz (%15) hastada iliak arter darlığı, 45 (%84,9) hastada yüzeyel femoral arter darlığı mevcuttu. Doppler US raporları, 11 (%20,8) hastada, ≥%50 stentiçi re-stenoz (Grup 1) olduğunu gösterdi. Re-stenoz oranları genç yaşta daha yüksekti (P=0,020). İki grup arasında cinsiyet (P=0,636), MPV (P=0,210), PLT sayısı (P=0,129) veya diğer hematolojik parametreler açısından istatistiksel olarak fark yoktu.

Sonuç: Birçok çalışmada özellikle MPV olmak üzere bazı kan parametrelerinin koroner ve periferik stent stenozu üzerinde etkili olduğu gösterilmiştir. Çalışmamızda, hematolojik veya kan parametrelerinin hiçbirinin biyobozunur stentlerin restenozunu öngöremediğini tespit ettik.

Keywords

Biyoeriyebilir stent, Periferik arter hastalığı, Trombosit sayıları, Ortalama trombosit hacmi

References

1. Karabay Ö, Karaçelik M, Yılık L, Tekin L, İriz A, Kumdereli S, et al Ischemic peripheral arterial disease: A screening survey. Turk Gogus Kalp Dama. 2012;20(3):450-7. DOI: 10.5606/tgkdc.dergisi.2012.089
2. David B, Edward W, Chrisopher T, A New Wave in Treatment of Vascular Occlusive Desease: Biodegradable Stents- Clinical experience and Scientific Principles. JVIR. 2009; 20(3):315-24. DOI: 10.1016/j.jvir.2008.11.007
3. Eren R, Doğu MH, Koç A, Altındal Ş, Yokuş O, Suyanı E. The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study. J Surg Med. 2019;3(2):176-9. DOI: 10.28982/josam.525751
4. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52 DOI: 10.28982/josam.530098
5. Werner M, Schmidt A, Scheinert S, Banning-Eichenseer U, Ulrich M, Bausback Y, et al. Evaluation of the Biodegradable Igaki-Tamai Scaffold After Drug-Eluting Balloon Treatment of De Novo Superficial Femoral Artery Lesions: The GAIA-DEB Study. J Endovasc Ther. 2016;23(1):92-7. DOI: 10.1177/1526602815620618
6. Onuma Y, Serruys PW. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization? Circulation. 2011;123(7):779-97. DOI: 10.1161/CIRCULATIONAHA.110.971606
7. Nishio S, Kosuga K, Igaki K, Okada M, Kyo E, Tsuji T, et al. Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents. Circulation. 2012;15:125(19):2343-53. DOI: 10.1161/CIRCULATIONAHA.110.000901
8. Werner M, Micari A, Cioppa A, Vadalà G, Schmidt A, Sievert H, et al Evaluation of the biodegradable peripheral Igaki-Tamai stent in the treatment of de novo lesions in the superficial femoral artery: the GAIA study JACC. Cardiovasc Interv. 2014;7(3):305-12. DOI: 10.1016/j.jcin.2013.09.009
9. Sansanayudh N, Muntham D, Yamwong S, Sritara P, Akrawichien T, Thakkinstian A. The Association between mean platelet volume and cardiovascular risk factors. Eur J Intern Med. 2016;30(5):37-42. DOI: 10.1016/j.ejim.2015.11.028
10. Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res. 2006;117(4):371-7. DOI: 10.1016/j.thromres.2005.04.004
11. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Athersclerosis. 2010;213(2):586-91. DOI: 10.1016/j.atherosclerosis.2010.09.010
12. Li S, Wang C, Zhong XW, Li HQ, FUXQ, Ran XW. Variance of mean platelet volume in subjects with normal glucose tolerance, impaired glucose regulation and type 2 diabetic mellitus and its relationship with diabetic peripheral artery disease. Zhonghua Yi Xue Za Zhi. 2012;92(2):232-5. PMID:22490792
13. Karauzum K, Bildirici U, Dervis E, Karauzum I, Baydemir C. Preprocedural Mean Platelet Volume Level Is a Predictor of In-Stent re-stenosis of the superficial femoral Artery Stents in Follow-Up. Cardiol Res Pract. 2018:4572629. DOI: 10.1155/2018/4572629
14. Dai Z, Gao J, Li S, Li R, Chen Z Mean Platelet Volume as a Predictor for Restenosis After Carotid Angioplasty and Stenting. Stroke. 2018;49(4):872-6. DOI: 10.1161/STROKEAHA.117.019748
15. Chan YC, Cheng SW, Cheung GC Predictors of restenosis in the use of helical interwoven nitinol stents to treat femoropopliteal occlusive disease. J Vasc Surg. 2015;62(5):1201-9. DOI: 10.1016/j.jvs.2015.05.030
16. Miller AJ, Takahashi EA, Harmsen WS, Mara KC, Misra S Treatment of Superficial Femoral Artery Restenosis. J Vasc Interv Radiol. 2017;28(12):1681-6. DOI: 10.1016/j.jvir.2017.07.032

There are 16 citations in total.

Details

Primary Language	English
Subjects	Cardiovascular Surgery
Journal Section	Research article
Authors	Engin Akgül 0000-0001-7361-0430 Mesut Engin 0000-0003-2418-5823 Ahmet Fatih Özyazıcıoğlu 0000-0001-8642-5664
Publication Date	September 1, 2019
Published in Issue	Year 2019 Volume: 3 Issue: 9

Cite

APA	Akgül, E., Engin, M., & Özyazıcıoğlu, A. F. (2019). Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. Journal of Surgery and Medicine, 3(9), 663-665. https://doi.org/10.28982/josam.569158
AMA	Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. September 2019;3(9):663-665. doi:10.28982/josam.569158
Chicago	Akgül, Engin, Mesut Engin, and Ahmet Fatih Özyazıcıoğlu. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine 3, no. 9 (September 2019): 663-65. https://doi.org/10.28982/josam.569158.
EndNote	Akgül E, Engin M, Özyazıcıoğlu AF (September 1, 2019) Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. Journal of Surgery and Medicine 3 9 663–665.
IEEE	E. Akgül, M. Engin, and A. F. Özyazıcıoğlu, “Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis”, J Surg Med, vol. 3, no. 9, pp. 663–665, 2019, doi: 10.28982/josam.569158.
ISNAD	Akgül, Engin et al. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine 3/9 (September 2019), 663-665. https://doi.org/10.28982/josam.569158.
JAMA	Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. 2019;3:663–665.
MLA	Akgül, Engin et al. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine, vol. 3, no. 9, 2019, pp. 663-5, doi:10.28982/josam.569158.
Vancouver	Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. 2019;3(9):663-5.