Serum galectin-3 levels and vitamin D relationship in heart failure

Year 2021, Volume: 5 Issue: 10, 1046 - 1049, 01.10.2021

Mustafa Özcan Murat Akarsu Şengül Aydın Yoldemir Özgür Altun Orkide Kutlu Semih Kalyon Gülden Yürüyen Perihan Özkan Gümüşkaya Neslihan Özsoy Hasan Eruzun Yücel Arman Tufan Tükek

https://doi.org/10.28982/josam.1003992

Abstract

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels.
Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group.
Results: Galectin-3 levels were high in patients with heart failure (P<0.001) and increased as the ejection fraction (EF) decreased (P=0.001). 25-OH vitamin D levels were lower in the patient group compared to the control group (P<0.001). There was no significant correlation between serum galectin-3 and vitamin D levels (r=-0.22; P=0.094); however, serum galectin-3 levels and the stage of CHF were correlated (r=0.66; P=0.001).
Conclusions: We found high serum galectin-3 levels in patients with heart failure and low 25 OH vitamin D levels. We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

Keywords

Galectin 3, Congestive heart failure, Vitamin D3 level

Supporting Institution

DETEKLEYEN KURUM YOKTUR

Thanks

Dear Editor, I am writing to submit our manuscript entitled, "Serum Galectin 3 Levels and Vıtamin D Relationship in Heart Failure" for consideration for publication in your journal. This manuscript describes original work and is not under consideration by any other journal. All authors approved the manuscript and this submission. There are no conflicts of interest. Corresponding Author: Dr. Mustafa Özcan, Şişli/ İstanbul, Turkey e-mail: [e-mail] Yours sincerely

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