A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions

Rabia Zeynep Kobak; Barbaros Akkurt

doi:10.18596/jotcsa.1886458

A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions

Abstract

Imidazo[1,2-a]pyridine is a powerful molecule, with thousands of references in the literature. The main reason is that the very positions of nitrogen atoms within the heterocyclic ring give rise to a wide range of activities. It is used as an enzyme inhibitor (for example, c-MET kinase, tyrosine kinase, serine/threonine kinase), antimicrobial agent (for Gram positive and negative bacteria), antitubercular compounds, nematicides and fungicides, antiviral agents against HIV viruses, and some reports mention of antifungal activity, anticancer activity (for example, PC-3 and MDA-MB-231, B16F10, MCF-7, HCT116, and HepG2 are discussed in this paper) and some metal complexes as mRNA inhibitor and sensor devices and their syntheses and related applications are becoming quite important in the chemical community. In this review article, we will discuss the biological activities and chemical synthesis methods of this heterocyclic compound, including its synthesis and the synthesis of other molecules starting from it. We also discussed the effect of substituents on the biological activity of the final compounds, where applicable. It is hoped that the readers will find this treatise useful.

Keywords

Thanks

The authors are thankful to Istanbul Technical University Scientific Research Fund, Project no: TGA-2024-45625.

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Details

Primary Language

English

Subjects

Organic Chemical Synthesis, Organic Chemistry (Other)

Journal Section

Review

Authors

Rabia Zeynep Kobak
0000-0001-9140-7487
Türkiye

Barbaros Akkurt ^*
0000-0003-4066-3004
Türkiye

Publication Date

June 2, 2026

Submission Date

February 10, 2026

Acceptance Date

April 30, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

DOI

https://doi.org/10.18596/jotcsa.1886458

IZ

https://izlik.org/JA76JT52FR

Cite

RIS / Bibtex

APA

Kobak, R. Z., & Akkurt, B. (2026). A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-35. https://doi.org/10.18596/jotcsa.1886458

AMA

1.Kobak RZ, Akkurt B. A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. JOTCSA. 2026;2026(2):1-35. doi:10.18596/jotcsa.1886458

Chicago

Kobak, Rabia Zeynep, and Barbaros Akkurt. 2026. “A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-35. https://doi.org/10.18596/jotcsa.1886458.

EndNote

Kobak RZ, Akkurt B (June 1, 2026) A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–35.

IEEE

[1]R. Z. Kobak and B. Akkurt, “A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions”, JOTCSA, vol. 2026, no. 2, pp. 1–35, June 2026, doi: 10.18596/jotcsa.1886458.

ISNAD

Kobak, Rabia Zeynep - Akkurt, Barbaros. “A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (June 1, 2026): 1-35. https://doi.org/10.18596/jotcsa.1886458.

JAMA

1.Kobak RZ, Akkurt B. A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. JOTCSA. 2026;2026:1–35.

MLA

Kobak, Rabia Zeynep, and Barbaros Akkurt. “A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, June 2026, pp. 1-35, doi:10.18596/jotcsa.1886458.

Vancouver

1.Rabia Zeynep Kobak, Barbaros Akkurt. A Mini-Review About Imidazopyridines: Syntheses, Biological Activities, and Reactions. JOTCSA. 2026 Jun. 1;2026(2):1-35. doi:10.18596/jotcsa.1886458