Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug
Abstract
This study reports the synthesis of new hydralazine-based heterocyclic derivatives (S1–S8), including β-lactam, aza-β-lactam, and quinazoline-4-one derivatives. First, Schiff bases (S1 and S2) were prepared by reacting hydralazine with substituted aromatic aldehydes. These Schiff bases were then cyclized with chloroacetyl chloride, phenyl isocyanate, and anthranilic acid to obtain β-lactam derivatives (S3 and S4), aza-β-lactam derivatives (S5 and S6), and quinazoline-4-one derivatives (S7 and S8), respectively. The synthesized compounds were characterized using FT-IR, ¹H NMR, and ¹³C NMR spectroscopy. In addition, their antioxidant activities were evaluated at three concentrations: 25, 50, and 100 ppm. The results indicated that the synthesized compounds exhibited moderate antioxidant activity, with increased activity at 100 ppm; however, their activities remained lower than that of ascorbic acid used as the standard.
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Details
Primary Language
English
Subjects
Organic Chemical Synthesis
Journal Section
Research Article
Authors
Aseel Hikmat
Iraq
Noor Kadhem
This is me
0009-0007-5997-1783
Iraq
Hind Sedeeq
This is me
0000-0001-8266-0819
Iraq
Rana Ali
This is me
0000-0002-2848-4604
Iraq
Sanaa Abdul Alsahib
This is me
0000-0002-3527-5464
Iraq
Publication Date
August 3, 2026
Submission Date
March 29, 2026
Acceptance Date
July 5, 2026
Published in Issue
Year 2026 Volume: 2026 Number: 2
