Research Article

Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug

Volume: 2026 Number: 2 August 3, 2026

Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug

Abstract

This study reports the synthesis of new hydralazine-based heterocyclic derivatives (S1–S8), including β-lactam, aza-β-lactam, and quinazoline-4-one derivatives. First, Schiff bases (S1 and S2) were prepared by reacting hydralazine with substituted aromatic aldehydes. These Schiff bases were then cyclized with chloroacetyl chloride, phenyl isocyanate, and anthranilic acid to obtain β-lactam derivatives (S3 and S4), aza-β-lactam derivatives (S5 and S6), and quinazoline-4-one derivatives (S7 and S8), respectively. The synthesized compounds were characterized using FT-IR, ¹H NMR, and ¹³C NMR spectroscopy. In addition, their antioxidant activities were evaluated at three concentrations: 25, 50, and 100 ppm. The results indicated that the synthesized compounds exhibited moderate antioxidant activity, with increased activity at 100 ppm; however, their activities remained lower than that of ascorbic acid used as the standard.

Keywords

Supporting Institution

there is no supporting institution

Project Number

Synthesis, Characterization, and Antioxidant Activities of New heterocyclic derivatives from Hydralazine drug

Thanks

I would like to thank the Department of Chemistry, College of Science, University of Baghdad, and the staff of the service laboratory.

References

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Details

Primary Language

English

Subjects

Organic Chemical Synthesis

Journal Section

Research Article

Publication Date

August 3, 2026

Submission Date

March 29, 2026

Acceptance Date

July 5, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

APA
Dhedan, R., Hikmat, A., Kadhem, N., Sedeeq, H., Ali, R., & Abdul Alsahib, S. (2026). Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-8. https://doi.org/10.18596/jotcsa.1915518
AMA
1.Dhedan R, Hikmat A, Kadhem N, Sedeeq H, Ali R, Abdul Alsahib S. Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug. JOTCSA. 2026;2026(2):1-8. doi:10.18596/jotcsa.1915518
Chicago
Dhedan, Ruaa, Aseel Hikmat, Noor Kadhem, Hind Sedeeq, Rana Ali, and Sanaa Abdul Alsahib. 2026. “Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-8. https://doi.org/10.18596/jotcsa.1915518.
EndNote
Dhedan R, Hikmat A, Kadhem N, Sedeeq H, Ali R, Abdul Alsahib S (August 1, 2026) Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–8.
IEEE
[1]R. Dhedan, A. Hikmat, N. Kadhem, H. Sedeeq, R. Ali, and S. Abdul Alsahib, “Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug”, JOTCSA, vol. 2026, no. 2, pp. 1–8, Aug. 2026, doi: 10.18596/jotcsa.1915518.
ISNAD
Dhedan, Ruaa - Hikmat, Aseel - Kadhem, Noor - Sedeeq, Hind - Ali, Rana - Abdul Alsahib, Sanaa. “Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (August 1, 2026): 1-8. https://doi.org/10.18596/jotcsa.1915518.
JAMA
1.Dhedan R, Hikmat A, Kadhem N, Sedeeq H, Ali R, Abdul Alsahib S. Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug. JOTCSA. 2026;2026:1–8.
MLA
Dhedan, Ruaa, et al. “Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, Aug. 2026, pp. 1-8, doi:10.18596/jotcsa.1915518.
Vancouver
1.Ruaa Dhedan, Aseel Hikmat, Noor Kadhem, Hind Sedeeq, Rana Ali, Sanaa Abdul Alsahib. Synthesis, Characterization, and Antioxidant Activities of New Heterocyclic Derivatives from Hydralazine Drug. JOTCSA. 2026 Aug. 1;2026(2):1-8. doi:10.18596/jotcsa.1915518