Research Article

Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment

Volume: 2026 Number: 2 June 26, 2026

Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment

Abstract

In this study, a selective potentiometric sensor was developed for nizatidine, a widely used drug for the treatment of various gastric disorders. Initially, the nizatidine–tetraphenylborate (NZ–TPB) ion pair was synthesized and subsequently incorporated as the electroactive sensing material in polymeric membrane sensors. The optimal membrane composition was determined to be 3.0% NZ–TPB ion pair, 32.0% poly(vinyl chloride) (PVC), and 65.0% o-nitrophenyl octyl ether (o-NPOE). Water layer tests were performed on the prepared sensor, and its surface morphology was examined using scanning electron microscopy (SEM). The developed nizatidine-selective potentiometric sensor exhibited a linear response over the concentration range of 1.0×10-2–1.0×10-5 M, with a detection limit of 5.91×10-6 M. The sensor exhibited a stable performance over a pH range of 4.0–10.0, with an average response time of approximately 10 s. he proposed sensor was successfully applied to the determination of nizatidine in fetal bovine serum (FBS) samples, achieving satisfactory recoveries of up to 96.70%. In addition, the environmental sustainability of the method was comprehensively assessed using AGREE and GAPI green analytical evaluation tools.

Keywords

Thanks

Financial support provided by the Scientific and Technological Research Council of Turkey (TUBITAK–2209A; Project Number: 1919B012414517). The authors thank to TUBITAK.

References

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Details

Primary Language

English

Subjects

Sensor Technology

Journal Section

Research Article

Publication Date

June 26, 2026

Submission Date

May 12, 2026

Acceptance Date

June 5, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

APA
Özbek, O., Elik, M., & Hidalgo Viteri, J. S. (2026). Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-10. https://doi.org/10.18596/jotcsa.1950103
AMA
1.Özbek O, Elik M, Hidalgo Viteri JS. Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment. JOTCSA. 2026;2026(2):1-10. doi:10.18596/jotcsa.1950103
Chicago
Özbek, Oğuz, Muhammed Elik, and Juan Santiago Hidalgo Viteri. 2026. “Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-10. https://doi.org/10.18596/jotcsa.1950103.
EndNote
Özbek O, Elik M, Hidalgo Viteri JS (June 1, 2026) Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–10.
IEEE
[1]O. Özbek, M. Elik, and J. S. Hidalgo Viteri, “Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment”, JOTCSA, vol. 2026, no. 2, pp. 1–10, June 2026, doi: 10.18596/jotcsa.1950103.
ISNAD
Özbek, Oğuz - Elik, Muhammed - Hidalgo Viteri, Juan Santiago. “Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (June 1, 2026): 1-10. https://doi.org/10.18596/jotcsa.1950103.
JAMA
1.Özbek O, Elik M, Hidalgo Viteri JS. Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment. JOTCSA. 2026;2026:1–10.
MLA
Özbek, Oğuz, et al. “Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, June 2026, pp. 1-10, doi:10.18596/jotcsa.1950103.
Vancouver
1.Oğuz Özbek, Muhammed Elik, Juan Santiago Hidalgo Viteri. Fabrication of a Nizatidine–Selective PVC Membrane Potentiometric Sensor in Biological Samples and Its Greenness Assessment. JOTCSA. 2026 Jun. 1;2026(2):1-10. doi:10.18596/jotcsa.1950103