Research Article

Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction

Volume: 2026 Number: 2 October 19, 2026

Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction

Abstract

A simple and sensitive spectrophotometric method was developed and validated for the determination of famotidine (FAT) in its pure form and in tablet formulations using an oxidation–reduction reaction. The method involves the oxidation of FAT with excess N-bromosuccinimide (NBS) in an acetic acid medium. Subsequently, the residual NBS reacts with p-anisidine (PAN) under acidic conditions to form a reddish-violet brominated product, whose absorbance is measured at 522 nm. Beer’s law was obeyed over the concentration range of 1–20 mg/L, with a molar absorptivity of 2.193 × 10⁴ L mol⁻¹ cm⁻¹. The limits of detection (LOD) and quantification (LOQ) were 0.034 and 0.114 mg/L, respectively. The method demonstrated high accuracy, with a mean recovery of 99.91%, and good precision, with relative standard deviation (RSD) values below 0.38%. The proposed method was successfully applied to the determination of FAT in pharmaceutical tablets.

Keywords

Thanks

The authors gratefully acknowledge the University of Mosul, particularly the College of Education for Pure Sciences and the College of Science, for providing the facilities necessary to conduct this research.

References

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Details

Primary Language

English

Subjects

Analytical Spectrometry

Journal Section

Research Article

Publication Date

October 19, 2026

Submission Date

July 3, 2026

Acceptance Date

September 3, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

APA
Zakaria, R., Al Abdali, Z., Othman, N., & Nathim, N. (2026). Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction. Journal of the Turkish Chemical Society Section A: Chemistry, 2026(2), 1-12. https://doi.org/10.18596/jotcsa.1986264
AMA
1.Zakaria R, Al Abdali Z, Othman N, Nathim N. Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction. JOTCSA. 2026;2026(2):1-12. doi:10.18596/jotcsa.1986264
Chicago
Zakaria, Rawaa, Zeena Al Abdali, Nabeel Othman, and Nagham Nathim. 2026. “Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction”. Journal of the Turkish Chemical Society Section A: Chemistry 2026 (2): 1-12. https://doi.org/10.18596/jotcsa.1986264.
EndNote
Zakaria R, Al Abdali Z, Othman N, Nathim N (October 1, 2026) Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction. Journal of the Turkish Chemical Society Section A: Chemistry 2026 2 1–12.
IEEE
[1]R. Zakaria, Z. Al Abdali, N. Othman, and N. Nathim, “Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction”, JOTCSA, vol. 2026, no. 2, pp. 1–12, Oct. 2026, doi: 10.18596/jotcsa.1986264.
ISNAD
Zakaria, Rawaa - Al Abdali, Zeena - Othman, Nabeel - Nathim, Nagham. “Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction”. Journal of the Turkish Chemical Society Section A: Chemistry 2026/2 (October 1, 2026): 1-12. https://doi.org/10.18596/jotcsa.1986264.
JAMA
1.Zakaria R, Al Abdali Z, Othman N, Nathim N. Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction. JOTCSA. 2026;2026:1–12.
MLA
Zakaria, Rawaa, et al. “Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction”. Journal of the Turkish Chemical Society Section A: Chemistry, vol. 2026, no. 2, Oct. 2026, pp. 1-12, doi:10.18596/jotcsa.1986264.
Vancouver
1.Rawaa Zakaria, Zeena Al Abdali, Nabeel Othman, Nagham Nathim. Development of Spectrophotometric Method for Determination of Famotidine in Tablets via Oxidation-Reduction Reaction. JOTCSA. 2026 Oct. 1;2026(2):1-12. doi:10.18596/jotcsa.1986264