SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITIES OF NOVEL 1-(MORPHOLINE-4-YL-METHYL)-3-ALKYL(ARYL)-4-[4-(DIMETHYLAMINO)-BENZYLIDENAMINO]-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-5-ONES

Year 2016, , 105 - 118, 08.01.2017

Özlem Gürsoy Kol Haydar Yüksek Sevda Manap Feyzi Sinan Tokalı

https://doi.org/10.18596/jotcsa.23635

Cited By: 6

Abstract

In this paper, eight novel 1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-[4-(dimethylamino)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were obtained by the reactions of 3-alkyl(aryl)-4-[4-(dimethylamino)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with formaldehyde and morpholine. The novel synthesized compounds were identified by IR, ¹H NMR and ¹³C NMR spectral data. Besides, the newly synthesized compounds were analysed for their in vitro potential antioxidant capacities in three different assays. All of the compounds demonstrated significant activity for metal chelating effect.

Keywords

4, 5-Dihydro-1H-1, 2, 4-triazol-5-one, Syntheses; Mannich base; Antioxidant capacity.

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