SYNTHESIS OF NOVEL FLUOROQUINOLONE-TRIAZOLE HYBRID COMPOUNDS AS ANTIMICROBIAL AGENTS

Abstract

Abstract: The hydrazide compound (2) was synthesized starting from 1-(2-fluorophenyl)piperazine via two stage. The reaction of compound (2) with different alkyl(aryl)isothiocyanates afforded the corresponding compounds (3a-c). 1,3-Thiazolidine derivatives (4a-c) were synthesized from the treatment of (3a-c) with ethyl bromoacetate. Mannich bases (6a-d) were yielded the treayment of (5a-c) with various suitable amines in the exictence of formaldehyde. Compound (3) derivatives were converted to 1,2,4-triazole as the starting material of fluoroquinolone analogues (11a-c). Finally synthesized compounds were examined their biological properties and some of these showed potent activity.

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