Synthesis of trans-diamide derivatives from fumaryl chloride and determination of DPPH scavenging activity of synthesized molecules

Abstract

In this work, new trans-diamide derivatives were synthesized with the reaction between fumaryl chloride and substituted anilines. After successful synthesis of trans-amides, antioxidant activity of all synthesized molecules was investigated via DPPH method and calculated IC50 values. All trans-amides were characterized by 1H-NMR, 13C-NMR, 19F-NMR, GC-MS and FTIR spectroscopic techniques.

Keywords

• Amides,DPPH method,Antioxidant activity

References

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