Synthesis of an Antimicrobial Thioanthraquinone Compound to Produce Biodegradable Electrospun Mats for Tissue Engineering Purposes

Year 2018, Volume: 5 Issue: 3, 1119 - 1134, 01.09.2018

Yeşim Müge Şahin

https://doi.org/10.18596/jotcsa.422255

Cited By: 3

Abstract

In the present study
for the first time in the literature, novel S-substituted bioactive
anthraquinone compound were synthesized with a new, easy and less energetic
reaction method (Patent Number: TR2016/19610) from 1-chloro-9,10-dihydrodiagnosisxy-anthraquinone
and butyl-3-mercaptopropionate. The resultant structure present remarkable
biological properties It was purified by column chromatography. All obtained
structures were characterized with spectroscopic methods (NMR, MS, FT-IR, UV
etc). Antimicrobial properties of bioactive compound were determined as well.
The resultant thioanthraquinone compound has been synthesized for the first
time in the literature and its applications as a biomaterial were discussed in
the present study.

Subsequently, biodegradable electrospun mats were
produced via electrospinning method for their usage in treatment as a
biomaterial. Structural (FTIR), morphological (FEG-SEM) biological
(antimicrobial and in-vitro tests) and mechanical (tensile testing) characterizations
were conducted for these nanobiomaterials. Presenting an advantage of the novel
antimicrobial compound, the produced electrospun nanobiocomposites exhibited
remarkable biological, mechanical properties. With a purposeful compound
synthesis and a subsequent nanobiocomposite production, the obtained
electrospun mats are good canditates for biomaterials for tissue engineering
purposes and wound healing materials. 

Keywords

Anthraquinone, synthesis, electrospun mat, biomaterial, biodegradable material, biomaterial

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