Synthesis, Spectroscopic Analysis, and Anti-Bacterial Studies of Pd(II) Complexes of Phosphine and Hydrazone Derivatives

Year 2024, Volume: 11 Issue: 1, 245 - 252, 04.02.2024

Laith H. K. Al-jibori Ahmed Shaker Marmus

https://doi.org/10.18596/jotcsa.1343254

Cited By: 1

Abstract

This study reports the synthesis of seven hydrazone derivative complexes by the treatment equivalent molar of the phosphine ligand Ph2P(CH2)nPPh2 {where n= 1 dppm; n=2 dppe; n=3 dppp; n=4
dppb; (CH2)n = (Cp)2Fe} with [Pd(dbeoz)2] afforded complexes of the type [Pd(dbeoz)2(diphos)] and [Pd(dbeoz)2(dppm)]2, whereas the reaction of two moles of Ph3P with [Pd(dbeoz)2] gave a complex [Pd(dbeoz)2(PPh3)2] in good yield. CHN analysis, conductivity measurements, Fourier Transform Infrared (FT-IR), 1H, and 31P-NMR, were used to investigate the structural geometries of the complexes. Further, the biological activity of the synthesized complexes was evaluated against three pathogenic bacteria (Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli) using the well diffusion method, the synthesized complexes displayed moderate to good inhibitory activity, and the [Pd(dbeoz)2(dppf)] complex exhibited the highest inhibitory activity with DIZ is 24, 27, and 28 mm against the three pathogenic bacteria, respectively.

Keywords

hydrazone, phosphine, Palladium, metal complexes, anti-bacterial activity

Thanks

The authors are thankful to Tikrit University for supporting this work

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