Synthesis of Some New 1,3,4-Thiadiazole Derivatives Derived from Cholic Acid and Evaluation of their Biological Activity

Year 2024, Volume: 11 Issue: 2, 425 - 432, 15.05.2024

Intisar Q M Alaraj , Rana A. Saeed Linda Reyadh , Amena A. Ahmed

https://doi.org/10.18596/jotcsa.1371936

Abstract

In this work, several oxadiazole, thiadiazole, and triazole derivatives, as well as new Schiff bases, were prepared. Cholic acid was used as a starting material to prepare the five-membered heterocyclic compounds. The synthesized compounds were identified by FTIR and 1H,13C-NMR spectroscopy, which elucidated and confirmed the structure of the target molecules. Estimation of the biological activity of the newly produced compounds has been conducted against two types of Gram-positive and Gram-negative pathogenic bacteria.

Keywords

Cholic acid, heterocyclic, Schiff bases, thiadiazoles, oxadiazoles, pathogenic bacteria

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