Search for new ionophores and determination of trace levels of Cu2+ ions by potentiometric ion–selective electrodes
Abstract
Copper(II) ions are essential at trace levels but become toxic at elevated concentrations, making their rapid and accurate determination in environmental samples highly important. This letter reports the performance of ionophore molecules synthesized by our research group for the potentiometric detection of Cu2+ using ion–selective electrodes. The developed sensors showed fast response, good selectivity, low detection limits, and simple operation, and were successfully applied to environmental samples. In addition, the use of newly designed ionophores offers a cost-effective alternative to commercial counterparts, reducing overall sensor fabrication costs while maintaining satisfactory analytical performance.
Keywords
References
- Adam, S. M., Wijeratne, G. B., Rogler, P. J., Diaz, D. E., Quist, D. A., Liu, J. J., & Karlin, K. D. (2018). Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function. Chemical reviews, 118(22), 10840-11022.
- Adhawiyah, R. E., & Lee, J. (2026). Nanomaterial-enhanced sensors for trace heavy metal ion detection: a review of electrochemical and optical methods. Micro and Nano Systems Letters, 14(1), 4.
- Aish, M., Alshehri, R. F., & Amin, A. S. (2023). Construction of an optical sensor for copper determination in environmental, food, and biological samples based on the covalently immobilized 2-(2-benzothiazolylazo)-3-hydroxyphenol in agarose. RSC advances, 13(35), 24777-24788.
- Altunoluk, O. C., Özbek, O., Kalay, E., Berkel, C., & Isildak, Ö. (2025). Synthesis and use of novel rhodanine derivatives to fabricate potentiometric sensors for the determination of toxic heavy metal ions. Microchemical Journal, 115090.
- Altunoluk, O. C., Özbek, O., Kalay, E., Berkel, C., & Isildak, Ö. (2026). Synthesis of new rhodanine derivative molecules, their biological properties and sensor applications in environmental samples. BMC chemistry, 20(1), 96.
- Bakker, E., & Pretsch, E. (2005). Potentiometric sensors for trace-level analysis. TrAC Trends in Analytical Chemistry, 24(3), 199-207.
- Berkil Akar, K., Özbek, O., Berkel, C., Eski, I. M., Bebek, O., & Altunoluk, O. C. (2026). The synthesis of a new 1, 4-anthraquinone derivative molecule: its use as an ionophore in potentiometric sensor design, and its influence on pro-inflammatory cell death of granulosa cells. Polyhedron, 117987.
- Bevan, R., & Levy, L. (2024). Biomonitoring for workplace exposure to copper and its compounds is currently not interpretable. International Journal of Hygiene and Environmental Health, 258, 114358.
Details
Primary Language
English
Subjects
Electrochemical Technologies
Journal Section
Letter to Editor
Authors
Oğuz Özbek
*
0000-0001-5185-9681
Türkiye
Publication Date
July 29, 2026
Submission Date
March 22, 2026
Acceptance Date
May 21, 2026
Published in Issue
Year 2026 Volume: 2026 Number: 2
