Synthesis, Characterization and Biological Activities of Novel Chiral Bis 1,2-diolcarbothioamides

Year 2024, Volume: 7 Issue: 2, 73 - 81, 18.12.2024

Arzu Karatepe , Pelin Koparır , Taner Daştan , Şule İnci , Serhat Keser , Ahmet Çetin

https://doi.org/10.54565/jphcfum.1539891

Abstract

2,2'-[(2R,3R)-2,3-dihydroxy-1,4-dioxobutane-1,4-diyl]bis(N-aryl-alkylhydrazine-1-carbothioamide (T1–5) were obtained by the interaction of (2R,3R)-2,3-dihydroxybutanedihydrazide (1) with five different isothiocyanate alkyl(aryl) derivatives. The structures of the final compounds were confirmed by elemental analyses, FT-IR, ¹H-NMR and ¹³C-NMR. The antioxidant, antimicrobial and anticancer properties of the synthesized compounds were also investigated. Three of the triazole derivatives with p-tolyl, benzyl and phenyl substituents (T3–5) displayed good antioxidant and anticancer activity in comparison to the standards.

Keywords

Carbothioamide, anticancer, antioxidant, antimicrobial

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