Post Vaccination Morphea in a Child

Year 2011, Volume: 3 Issue: 3, 1 - 5, 20.07.2011

Praveen Kumar , Peter Noronha

Abstract

Morphea also termed as localized scleroderma is a rare, chronic skin condition. It is classified into five types. The etiology and pathogenesis is largely unknown but a variety of triggers have been implicated as predisposing factors, including local trauma. There have been a few case reports about the possible association of immunization and subsequent development of morphea. We present a child in whom we believe, the lesions of morphea occurred after routine childhood immunization.

Keywords

scleroderma, vaccination, child

References

• Peterson LS, Nelson AM, Su WP, Mason T, O‟Fallon WM. Gabriel SE. The epidemiology of morphea (localized scleroderma) in Olmsted County 1960 – 1993. J Rheumatol 1997; 24:73- 80.
• Toledano C, Rabhi S, Kettaneh A, Fabre B, Fardet L, Tiev KP, Cabane J. Localized scleroderma: a series of 52 patients. Eur. J Intern Med. 2009; 20(3):331-6.
• Zulian, F, Athreya, BH, Laxer, R, et al. Juvenile localized epidemiological features in 750 children. An international study. Rheumatology 2006; 45:614- 620. clinical and
• Liu, B, Connolly, MK. The pathogenesis of cutaneous fibrosis. Semin. Cutan. Med Surg. 1998; 17:3-11.
• Vancheeswaran, R, Black, CM, David, J, et al. Childhood-onset scleroderma: Is it different from adult-onset disease? Arthritis Rheum 1996; 39:1041-1049.
• Desmons F, Tondeur JF, Hanu S et al. Linear and multiple scleroatrophic condition of the lower limbs in a 7-month-old infant: Etiopathogenic discussion. Ann Dermatol. Venereol. 1979; 106:1007–1010.
• Mork NJ. Clinical and histopathologic morphea with erythematosus: a case report. Acta Derm Venereol 1981; 61:367–368. evidence of lupus
• Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatric. Dermatol. 2006; 23(5):484-7.
• Schmutz JL, Posth M, Granel F et al. Localized scleroderma after hepatitis B vaccination. Presse Med 2000;29:1046.
• Grezard P, Perrollaz S, Canilot S et al. Scle`rodermie enplaques et vaccination contre l‟he´patite B. Nouv Dermatol 1996;15:516–518
• Bonino MV, Bianchi C, Bianchi O et al. Esclerodermia nodular post-trauma´ tica. Med Cutan Ibero Lat Am 1983;11:329–332.
• Drago F, Rampini P, Lugani C et al. Generalized morphoea after antitetanus vaccination. Clin Exp Dermatol 1998;23:142.
• Christen-Zaech S, Hakim MD, Afsar FS, Paller AS. Pediatric morphea (localized scleroderma): review of 136 patients. J Am Acad. Dermatol. 2008; 59(3):385-396. 14. Haustein, UF, Haupt, scleroderma and sclerodermiform conditions. Clin. Dermatol. 1998; 16:353-366. Drug-induced
• Ueda T, Niiyama S, Amoh Y, Katsuoka K. Linear scleroderma after contusion and injection of mepivacaine hydrochloride. Dermatol Online J 2010;16(5):11.
• Peterson LS, Nelson, AM, Su, WP. Classification of morphea (localized scleroderma). Mayo Clin Proc 1995; 70:1068-1076.
• Laxer RM, Zulian F. Localized scleroderma. Curr Opin Rheumatol 18:606–613.
• Zulian, F, Vallongo, C, Woo, P, et al. Localized scleroderma in childhood is not just a skin disease. Arthritis Rheum 2005; 52:2873-2881.
• De Rie MA, Bos JD. Photochemotherapy for systemic and localized scleroderma. J Am Acad Dermatol 2000;43:725-6.
• Birdi, N, Laxer, RM, Thorner, P, et al. Localized scleroderma progressing to systemic disease. Case report and review of the literature. Arthritis Rheum 1993; 36:410-415.