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Helicobacter pylori infection in children

Year 2011, Volume: 3 Issue: 4, 1 - 15, 05.11.2011

Abstract

Helicobacter pylori infection is mainly acquired during childhood period. It is recognised as a cause of gastritis and peptic ulcer and it has been classified as a group A carcinogen by the World Health Organisation. There is emerging evidence in different populations including developing countries that the prevalence of H.pylori is declining in all age groups. Neither the treatment of the infection nor improvement in socioeconomic factors fully explains the decline. Most of the infected children are asymtomatic, and there is no specific clinical picture indicating a need to screen for H. pylori in pediatric age groups. Although there is abundance of invasive and non-invasive tests for the diagnosis of the infection, there is still no single noninvasive diagnostic test for the diagnosis of H.pylori in children, particularly in infants. Additionally, the real outcome of the infecion in children is still obscure. The scope of this review was to discuss the epidemiology, clinical features, diagnostic techniques, and management of H.pylori infection pediatric paitents.

References

  • Mourad-Baars P, Hussey S, Jones NL. Helicobacter pylori infection and childhood. Helicobacter. 2010, 15 (Suppl 1):53-9.
  • Ford AC, Axon AT. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter. 2010, 15 (Suppl 1):1-6.
  • Acosta Garcia EJ, Valery MCP, Rodriguez LS. Helicobacter pylori and its relationship with minerals in school children. Salus 2009;13:61–8.
  • Chi H, Bair M-J, Wu M-S, et al. Prevalence of Helicobacter pylori infection in high-school students on Lanyu island, Taiwan: risk factor analysis and effect on growth. J Formos Med Assoc 2009;108:929–36.
  • Dube C, Nkosi TC, Clarke AM, Mkwetshana N, Green E, Ndip RN. Helicobacter pylori antigenemia in an asymptomatic population of Eastern Cape Province, South Africa: public health implications. Rev Environ Health 2009;24:249–55.
  • Jafri W, Yakoob J, Abid S, et al. Helicobacter pylori infection in children: population-based agespecific prevalence and risk factors in a developing country. Acta Paediatr 2010;99:279–82.
  • Santos IS, Boccio J, Davidsson L, et al. Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela. Public Health Nutr 2009;12:1862– 70.
  • Nouraie M, Latifi-Navid S, Rezvan H, Radmard AR, Maghsudlu M, Zaer-Rezaii H, et al. Childhood hygienic practice and family education status determine the prevalence of Helicobacter pylori infection in Iran. Helicobacter 2009;14:40–6.
  • Imrie C. Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? Pediatrics 2001, 107 : 373 -80.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007, 56: 772– 781.
  • Ozden A, Bozdayi G, Ozkan M, Köse S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years. Turk J Gastroenterol. 2004, 15(3):1568.
  • Ertem D, et al. Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding. The Turkish Journal of Pediatrics 2003; 44:114122.
  • Tam YH, Yeung CK, Lee KH, Sihoe JD, Chan KW, Cheung ST, et al. A populationbased study of Helicobacter pylori infection in Chinese children resident in Hong Kong: prevalence and potential risk factors. Helicobacter 2008, 13:219–24.
  • Travis PB, Goodman KJ, O'Rourke KM, et al. The association of drinking water quality and sewage disposal with Helicobacter pylori incidence in infants: the potential role of water-borne transmission. J Water Health. 2010, 8:192-203.
  • Dube C, Tanih NF, Ndip RN. Helicobacter pylori in water sources: a global environmental health concern. Rev Environ Health. 2009, 24:1-14.
  • Weyermann M, Rothenbacher D, Brenner H. Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings. Am J Gastroenterol. 2009, 104:182-9.
  • Konno M, Yokota S, Suga T, Takahashi M, Sato K, Fujii N. Predominance of mother-tochild transmission of Helicobacter pylori infection detected by random amplified polymorphic DNA fingerprinting analysis in Japanese families. Pediatr Infect Dis J. 2008, 27:999-1003.
  • Tkachenko MA, Zhannat NZ, Erman LV, et al. Dramatic changes in the prevalence of Helicobacter pylori infection during childhood: a 10-year follow-up study in Russia. J Pediatr Gastroenterol Nutr. 2007, 45:428-32.
  • Sykora J, Siala K, Varvarovska J, et al. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population-based study from the Czech Republic. Application of a monoclonal-based antigen-instool enzyme immunoassay. Helicobacter 2009;14:286–97.
  • Özen A, Ertem D, Pehlivanoglu E. Natural history and symptomatology of Helicobacter pylori in childhood and factors determining the epidemiology of infection. J Pediatr Gastroenterol Nutr. 2006, 42:398-404.
  • Yucel T, Aygin D, Sen S, Yucel O. The prevalence of Helicobacter pylori and related factors among university students in Turkey. Jpn J Infect Dis 2008, 61:179–83.
  • Mourad-Baars P, Hussey S, Jones NL. Helicobacter pylori infection and childhood. Helicobacter 2010, 15 (suppl1):53-9.
  • Berger MY, Spee LAA , Madderom MB, et al. Association between Helicobacter pylori and gastrointestinal symptoms in children. Pediatrics 2010, 125: e651-e669.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007, 56: 772–781
  • Jones NL, Sherman P, Fallone CA, et al. Canadian Helicobacter Study Group Consensus Conference: update on the approach to evidence-based evaluation. Can J Gastroenterol 2005, 9:399–408.
  • Uğras M, Ertem D, Baş E, Celikel C, Pehlivanoglu E. Peptic ulcer is a rising problem in children. Helicobacter 12(4): 461, 2007.
  • Hishida A, Matsuo K, Goto Y, Hamajima N. Genetic predisposition to Helicobacter pyloriinduced gastric precancerous conditions. World J Gastrointest Oncol. 2010, 15:369-79.
  • Selgrad M, Bornschein J, Rokkas T, Malfertheiner P. Clinical aspects of gastric cancer and Helicobacter pylori--screening, prevention, and treatment. Helicobacter. 2010, 15 (Suppl 1):40-5.
  • Muhsen K, Cohen D. Helicobacter pyloriInfection and iron stores: A systematic review and meta-analysis. Helicobacter 2008, 13:323-40.
  • Qu XH, Huang XL, Xiong P, et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World J Gastroenterol. 2010, 16:886-96.
  • Barabino A, Dufour C, Marino CE, et al. Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr GastroenterolNutr 1999;28:116–9.
  • Baysoy G, Ertem D, Ademoglu E, et al. Gastric Histopathology, Iron Status and Iron Deficiency Anemia in Children with Helicobacter pylori Infection. J Pediatr Gastroenterol Nutr 2004, 38:146-151.
  • Huang X, Qu X, Yan W et al. Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010, 86:272-278.
  • Soylu OB, Ozturk Y. Helicobacter pylori infection: effect on malnutrition and growth failure in dyspeptic children. Eur J Pediatr 2008, 167:557–62.
  • Cherian S, Forbes D, Sanfilippo F, Cook A, Burgner D. Helicobacter pylori, helminth infections and growth: a cross-sectional study in a high prevalence population. Acta Paediatr 2009, 98:860–4.
  • Ertem D, Pehlivanoglu E. Helicobacter pylori may influence height in children independent of socioeconomic factors. Pediatr Gastroenterol Nutr. 2002, 35:232-3.
  • McCune A, Lane A, Murray L, et al. Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2003, 15:637–40.
  • Fullerton D, Britton JR, Lewis SA, et al. Helicobacter pylori and lung function, asthma, atopy and allergic disease--a population-based cross-sectional study in adults. Int J Epidemiol. 2009, 38: 419-26.
  • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911–20.
  • Çam S, Ertem D, Bahçeciler N, et al. The interaction between H.pylori and atopy: Does inverse association really exist? Helicobacter 2009, 14:1-8.
  • Yang HR, Ko JS, Seo JK. Does the diagnostic accuracy of the 13C-urea breath test vary with age even after the application of urea hydrolysis rate? Helicobacter 2008;13:239– 44.
  • Elitsur Y, Tolia V, Gilger M et al (2009) Urea breath test in children: the United States prospective, multicenter study. Helicobacter 14: 134–140.
  • Wu DC, Wu IC, Wang SW, et al. Comparison of stool enzyme immunoassay and immunochromatographic method for detecting Helicobacter pylori antigens before and after eradication. Diagn Microbiol Infect Dis. 2006, 56:373-8.
  • Raguza D, Machado RS, Ogata SK, et al. Validation of a monoclonal stool antigen test for diagnosing Helicobacter pylori infection in young children. J Pediatr Gastroenterol Nutr 2010, 50:400–403.
  • Falsafi T, Favaedi R, Mahjoub F, Najafi M. Application of stool-PCR test for diagnosis of Helicobacter pylori infection in children. World J Gastroenterol 2009;15:484–8.
  • Leal YA, Flores LL, García-Cortés LB, et al. Antibody-based detection tests for the diagnosis of Helicobacter pylori infection in children: a meta-analysis. PLoS One. 2008, 3::e3751.
  • Guarner J, Kalach N, Elitsur Y, Koletzko S. Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009. Eur J Pediatr 2010, 169:15–25.
  • Jaramillo Y, Nares-Cisneros J, MartínezOrdaz VA, et al. Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns. Pediatr Dev Pathol. 2010 Jul 26. [Epub ahead of print].
  • Tutar E, Ertem D, Karaa EK, et al. Endoscopic and histopathologic findings associated with H. pylori infection in very young children. Dig Dis Sci 2009, 54:111-7.
  • Akcam M, Artan R, Gelen T, et al. Long-term aspects of nodular gastritis in children. Pediatr Int. 2007, 49: 220-5.
  • Madani S, Rabah R, Tolia V. Diagnosis of Helicobacter pylori infection from antral biopsies in pediatric patients: is urease test that reliable? Dig Dis Sci 2000, 45:1233– 1237.
  • Oderda G, Shcherbakov P, Bontems P, et al. Results from the pediatric European register for treatment of Helicobacter pylori (PERTH). Helicobacter 2007;12:150–6.
  • Francavilla R, Lionetti E, Castellaneta SP, et al. Improved efficacy of 10-day sequential treatment for Helicobacter pylori eradication in children: a randomized trial. Gastroenterology 2005, 129:1414–9.
  • Gatta L, Vakil N, Leandro G, Di Mario F, Vaira D. Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol 2009, 104:3069–79.
  • Francavilla R, Lionetti E, Castellaneta SP, et al. Clarithromycin resistant genotypes and eradication of H.pylori. Pediatrics 2010, 157:228-232.
  • Vandenplas Y, Brunser O, Szajewska H. Saccharomyces boulardii in childhood. Eur J Pediatr 2009, 168:253–65.
  • Szajewska H, Albrecht P, TopczewskaCabanek A. Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. J Pediatr Gastroenterol Nutr 2009, 48:431–6.
  • Kato S, Fujimura S. Primary antimicrobial resistance of Helicobacter pylori in children during the past 9 years. Pediatr Int 2010, 52:187–90.
  • Ahmad N, Zakaria WR, Abdullah SA, Mohamed R. Characterization of clarithromycin resistance in Malaysian isolates of Helicobacter pylori. World J Gastroenterol 2009, 15:3161–5.
  • Chang WL, Sheu BS, Cheng HC, et al. Resistance to metronidazole, clarithromycin and levofloxacin of Helicobacter pylori before and after clarithromycin-based therapy in Taiwan. J Gastroenterol Hepatol 2009, 24:1230–5.
  • Alvarez A, Moncayo JI, Santacruz JJ, et al. Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia. Antimicrob Agents Chemother 2009, 53:4022–4.
  • Koletzko S, Richy F, Bontems P, et al.. The European Paediatric Task Force on Helicobacter pylori. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 2006, 55:1711-6.
  • Bakir Ozbey S, Ozakin C, Keskin M. Antibiotic resistance rates of Helicobacter pylori isolates and the comparison of E-test and fluorescent in situ hybridization methods for the detection of clarithromycin resistant strains. Mikrobiyol Bul. 2009, 43:227-34.
  • O’Connor A, Gisbert JP, McNamara D, O’Morain C. Treatment of Helicobacter pylori infection 2010. Helicobacter 2010, (supp1) 46-52.
  • Zevit N, Levy I, Shmuely H, Samra Z, Yahav J. Antibiotic resistance of Helicobacter pylori in Israeli children. Scand J Gastroenterol 2010;45:550–5.
  • Rupnow MF, Chang AH, Shachter RD, Owens DK, Parsonnet J. Cost-effectiveness of a potential prophylactic Helicobacter pylori vaccine in the United States. J Infect Dis 2009, 200:1311–7.
  • Michetti P, Corthésy-Theulaz I, Davin C, Haas R, Vaney AC, Heitz M, et al. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 1994, 107: 1002-11
  • Guy B, Hessler C, Fourage S, Haensler J, et al. Systemic immunization with urease protects mice against Helicobacter pylori infection. Vaccine 1998; 16 : 850-6.
  • Fujihashi K, Koga T, van Ginkel FW, et al. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 2002; 20 : 2431-8.
  • Hickey DK, Aldwell FE, Tan ZY, Bao S, Beagley KW. Transcutaneous immunization with novel lipid-based adjuvants induces protection against gastric Helicobacter pylori infection. Vaccine 2009;27:6983–90.
Year 2011, Volume: 3 Issue: 4, 1 - 15, 05.11.2011

Abstract

References

  • Mourad-Baars P, Hussey S, Jones NL. Helicobacter pylori infection and childhood. Helicobacter. 2010, 15 (Suppl 1):53-9.
  • Ford AC, Axon AT. Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter. 2010, 15 (Suppl 1):1-6.
  • Acosta Garcia EJ, Valery MCP, Rodriguez LS. Helicobacter pylori and its relationship with minerals in school children. Salus 2009;13:61–8.
  • Chi H, Bair M-J, Wu M-S, et al. Prevalence of Helicobacter pylori infection in high-school students on Lanyu island, Taiwan: risk factor analysis and effect on growth. J Formos Med Assoc 2009;108:929–36.
  • Dube C, Nkosi TC, Clarke AM, Mkwetshana N, Green E, Ndip RN. Helicobacter pylori antigenemia in an asymptomatic population of Eastern Cape Province, South Africa: public health implications. Rev Environ Health 2009;24:249–55.
  • Jafri W, Yakoob J, Abid S, et al. Helicobacter pylori infection in children: population-based agespecific prevalence and risk factors in a developing country. Acta Paediatr 2010;99:279–82.
  • Santos IS, Boccio J, Davidsson L, et al. Helicobacter pylori is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela. Public Health Nutr 2009;12:1862– 70.
  • Nouraie M, Latifi-Navid S, Rezvan H, Radmard AR, Maghsudlu M, Zaer-Rezaii H, et al. Childhood hygienic practice and family education status determine the prevalence of Helicobacter pylori infection in Iran. Helicobacter 2009;14:40–6.
  • Imrie C. Is Helicobacter pylori infection in childhood a risk factor for gastric cancer? Pediatrics 2001, 107 : 373 -80.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007, 56: 772– 781.
  • Ozden A, Bozdayi G, Ozkan M, Köse S. Changes in the seroepidemiological pattern of Helicobacter pylori infection over the last 10 years. Turk J Gastroenterol. 2004, 15(3):1568.
  • Ertem D, et al. Helicobacter pylori infection in Turkish preschool and school children: role of socioeconomic factors and breast feeding. The Turkish Journal of Pediatrics 2003; 44:114122.
  • Tam YH, Yeung CK, Lee KH, Sihoe JD, Chan KW, Cheung ST, et al. A populationbased study of Helicobacter pylori infection in Chinese children resident in Hong Kong: prevalence and potential risk factors. Helicobacter 2008, 13:219–24.
  • Travis PB, Goodman KJ, O'Rourke KM, et al. The association of drinking water quality and sewage disposal with Helicobacter pylori incidence in infants: the potential role of water-borne transmission. J Water Health. 2010, 8:192-203.
  • Dube C, Tanih NF, Ndip RN. Helicobacter pylori in water sources: a global environmental health concern. Rev Environ Health. 2009, 24:1-14.
  • Weyermann M, Rothenbacher D, Brenner H. Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings. Am J Gastroenterol. 2009, 104:182-9.
  • Konno M, Yokota S, Suga T, Takahashi M, Sato K, Fujii N. Predominance of mother-tochild transmission of Helicobacter pylori infection detected by random amplified polymorphic DNA fingerprinting analysis in Japanese families. Pediatr Infect Dis J. 2008, 27:999-1003.
  • Tkachenko MA, Zhannat NZ, Erman LV, et al. Dramatic changes in the prevalence of Helicobacter pylori infection during childhood: a 10-year follow-up study in Russia. J Pediatr Gastroenterol Nutr. 2007, 45:428-32.
  • Sykora J, Siala K, Varvarovska J, et al. Epidemiology of Helicobacter pylori infection in asymptomatic children: a prospective population-based study from the Czech Republic. Application of a monoclonal-based antigen-instool enzyme immunoassay. Helicobacter 2009;14:286–97.
  • Özen A, Ertem D, Pehlivanoglu E. Natural history and symptomatology of Helicobacter pylori in childhood and factors determining the epidemiology of infection. J Pediatr Gastroenterol Nutr. 2006, 42:398-404.
  • Yucel T, Aygin D, Sen S, Yucel O. The prevalence of Helicobacter pylori and related factors among university students in Turkey. Jpn J Infect Dis 2008, 61:179–83.
  • Mourad-Baars P, Hussey S, Jones NL. Helicobacter pylori infection and childhood. Helicobacter 2010, 15 (suppl1):53-9.
  • Berger MY, Spee LAA , Madderom MB, et al. Association between Helicobacter pylori and gastrointestinal symptoms in children. Pediatrics 2010, 125: e651-e669.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007, 56: 772–781
  • Jones NL, Sherman P, Fallone CA, et al. Canadian Helicobacter Study Group Consensus Conference: update on the approach to evidence-based evaluation. Can J Gastroenterol 2005, 9:399–408.
  • Uğras M, Ertem D, Baş E, Celikel C, Pehlivanoglu E. Peptic ulcer is a rising problem in children. Helicobacter 12(4): 461, 2007.
  • Hishida A, Matsuo K, Goto Y, Hamajima N. Genetic predisposition to Helicobacter pyloriinduced gastric precancerous conditions. World J Gastrointest Oncol. 2010, 15:369-79.
  • Selgrad M, Bornschein J, Rokkas T, Malfertheiner P. Clinical aspects of gastric cancer and Helicobacter pylori--screening, prevention, and treatment. Helicobacter. 2010, 15 (Suppl 1):40-5.
  • Muhsen K, Cohen D. Helicobacter pyloriInfection and iron stores: A systematic review and meta-analysis. Helicobacter 2008, 13:323-40.
  • Qu XH, Huang XL, Xiong P, et al. Does Helicobacter pylori infection play a role in iron deficiency anemia? A meta-analysis. World J Gastroenterol. 2010, 16:886-96.
  • Barabino A, Dufour C, Marino CE, et al. Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr GastroenterolNutr 1999;28:116–9.
  • Baysoy G, Ertem D, Ademoglu E, et al. Gastric Histopathology, Iron Status and Iron Deficiency Anemia in Children with Helicobacter pylori Infection. J Pediatr Gastroenterol Nutr 2004, 38:146-151.
  • Huang X, Qu X, Yan W et al. Iron deficiency anaemia can be improved after eradication of Helicobacter pylori. Postgrad Med J 2010, 86:272-278.
  • Soylu OB, Ozturk Y. Helicobacter pylori infection: effect on malnutrition and growth failure in dyspeptic children. Eur J Pediatr 2008, 167:557–62.
  • Cherian S, Forbes D, Sanfilippo F, Cook A, Burgner D. Helicobacter pylori, helminth infections and growth: a cross-sectional study in a high prevalence population. Acta Paediatr 2009, 98:860–4.
  • Ertem D, Pehlivanoglu E. Helicobacter pylori may influence height in children independent of socioeconomic factors. Pediatr Gastroenterol Nutr. 2002, 35:232-3.
  • McCune A, Lane A, Murray L, et al. Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 2003, 15:637–40.
  • Fullerton D, Britton JR, Lewis SA, et al. Helicobacter pylori and lung function, asthma, atopy and allergic disease--a population-based cross-sectional study in adults. Int J Epidemiol. 2009, 38: 419-26.
  • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911–20.
  • Çam S, Ertem D, Bahçeciler N, et al. The interaction between H.pylori and atopy: Does inverse association really exist? Helicobacter 2009, 14:1-8.
  • Yang HR, Ko JS, Seo JK. Does the diagnostic accuracy of the 13C-urea breath test vary with age even after the application of urea hydrolysis rate? Helicobacter 2008;13:239– 44.
  • Elitsur Y, Tolia V, Gilger M et al (2009) Urea breath test in children: the United States prospective, multicenter study. Helicobacter 14: 134–140.
  • Wu DC, Wu IC, Wang SW, et al. Comparison of stool enzyme immunoassay and immunochromatographic method for detecting Helicobacter pylori antigens before and after eradication. Diagn Microbiol Infect Dis. 2006, 56:373-8.
  • Raguza D, Machado RS, Ogata SK, et al. Validation of a monoclonal stool antigen test for diagnosing Helicobacter pylori infection in young children. J Pediatr Gastroenterol Nutr 2010, 50:400–403.
  • Falsafi T, Favaedi R, Mahjoub F, Najafi M. Application of stool-PCR test for diagnosis of Helicobacter pylori infection in children. World J Gastroenterol 2009;15:484–8.
  • Leal YA, Flores LL, García-Cortés LB, et al. Antibody-based detection tests for the diagnosis of Helicobacter pylori infection in children: a meta-analysis. PLoS One. 2008, 3::e3751.
  • Guarner J, Kalach N, Elitsur Y, Koletzko S. Helicobacter pylori diagnostic tests in children: review of the literature from 1999 to 2009. Eur J Pediatr 2010, 169:15–25.
  • Jaramillo Y, Nares-Cisneros J, MartínezOrdaz VA, et al. Chronic Gastritis Associated with Helicobacter pylori in Mexican Children: Histopathological Patterns. Pediatr Dev Pathol. 2010 Jul 26. [Epub ahead of print].
  • Tutar E, Ertem D, Karaa EK, et al. Endoscopic and histopathologic findings associated with H. pylori infection in very young children. Dig Dis Sci 2009, 54:111-7.
  • Akcam M, Artan R, Gelen T, et al. Long-term aspects of nodular gastritis in children. Pediatr Int. 2007, 49: 220-5.
  • Madani S, Rabah R, Tolia V. Diagnosis of Helicobacter pylori infection from antral biopsies in pediatric patients: is urease test that reliable? Dig Dis Sci 2000, 45:1233– 1237.
  • Oderda G, Shcherbakov P, Bontems P, et al. Results from the pediatric European register for treatment of Helicobacter pylori (PERTH). Helicobacter 2007;12:150–6.
  • Francavilla R, Lionetti E, Castellaneta SP, et al. Improved efficacy of 10-day sequential treatment for Helicobacter pylori eradication in children: a randomized trial. Gastroenterology 2005, 129:1414–9.
  • Gatta L, Vakil N, Leandro G, Di Mario F, Vaira D. Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol 2009, 104:3069–79.
  • Francavilla R, Lionetti E, Castellaneta SP, et al. Clarithromycin resistant genotypes and eradication of H.pylori. Pediatrics 2010, 157:228-232.
  • Vandenplas Y, Brunser O, Szajewska H. Saccharomyces boulardii in childhood. Eur J Pediatr 2009, 168:253–65.
  • Szajewska H, Albrecht P, TopczewskaCabanek A. Randomized, double-blind, placebo-controlled trial: effect of lactobacillus GG supplementation on Helicobacter pylori eradication rates and side effects during treatment in children. J Pediatr Gastroenterol Nutr 2009, 48:431–6.
  • Kato S, Fujimura S. Primary antimicrobial resistance of Helicobacter pylori in children during the past 9 years. Pediatr Int 2010, 52:187–90.
  • Ahmad N, Zakaria WR, Abdullah SA, Mohamed R. Characterization of clarithromycin resistance in Malaysian isolates of Helicobacter pylori. World J Gastroenterol 2009, 15:3161–5.
  • Chang WL, Sheu BS, Cheng HC, et al. Resistance to metronidazole, clarithromycin and levofloxacin of Helicobacter pylori before and after clarithromycin-based therapy in Taiwan. J Gastroenterol Hepatol 2009, 24:1230–5.
  • Alvarez A, Moncayo JI, Santacruz JJ, et al. Antimicrobial susceptibility and mutations involved in clarithromycin resistance in Helicobacter pylori isolates from patients in the western central region of Colombia. Antimicrob Agents Chemother 2009, 53:4022–4.
  • Koletzko S, Richy F, Bontems P, et al.. The European Paediatric Task Force on Helicobacter pylori. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 2006, 55:1711-6.
  • Bakir Ozbey S, Ozakin C, Keskin M. Antibiotic resistance rates of Helicobacter pylori isolates and the comparison of E-test and fluorescent in situ hybridization methods for the detection of clarithromycin resistant strains. Mikrobiyol Bul. 2009, 43:227-34.
  • O’Connor A, Gisbert JP, McNamara D, O’Morain C. Treatment of Helicobacter pylori infection 2010. Helicobacter 2010, (supp1) 46-52.
  • Zevit N, Levy I, Shmuely H, Samra Z, Yahav J. Antibiotic resistance of Helicobacter pylori in Israeli children. Scand J Gastroenterol 2010;45:550–5.
  • Rupnow MF, Chang AH, Shachter RD, Owens DK, Parsonnet J. Cost-effectiveness of a potential prophylactic Helicobacter pylori vaccine in the United States. J Infect Dis 2009, 200:1311–7.
  • Michetti P, Corthésy-Theulaz I, Davin C, Haas R, Vaney AC, Heitz M, et al. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 1994, 107: 1002-11
  • Guy B, Hessler C, Fourage S, Haensler J, et al. Systemic immunization with urease protects mice against Helicobacter pylori infection. Vaccine 1998; 16 : 850-6.
  • Fujihashi K, Koga T, van Ginkel FW, et al. A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants. Vaccine 2002; 20 : 2431-8.
  • Hickey DK, Aldwell FE, Tan ZY, Bao S, Beagley KW. Transcutaneous immunization with novel lipid-based adjuvants induces protection against gastric Helicobacter pylori infection. Vaccine 2009;27:6983–90.
There are 70 citations in total.

Details

Primary Language English
Journal Section Reviews
Authors

Deniz Ertem

Publication Date November 5, 2011
Published in Issue Year 2011 Volume: 3 Issue: 4

Cite

APA Ertem, D. (2011). Helicobacter pylori infection in children. Journal of Pediatric Sciences, 3(4), 1-15. https://doi.org/10.17334/jps.00191
AMA Ertem D. Helicobacter pylori infection in children. Journal of Pediatric Sciences. November 2011;3(4):1-15. doi:10.17334/jps.00191
Chicago Ertem, Deniz. “Helicobacter Pylori Infection in Children”. Journal of Pediatric Sciences 3, no. 4 (November 2011): 1-15. https://doi.org/10.17334/jps.00191.
EndNote Ertem D (November 1, 2011) Helicobacter pylori infection in children. Journal of Pediatric Sciences 3 4 1–15.
IEEE D. Ertem, “Helicobacter pylori infection in children”, Journal of Pediatric Sciences, vol. 3, no. 4, pp. 1–15, 2011, doi: 10.17334/jps.00191.
ISNAD Ertem, Deniz. “Helicobacter Pylori Infection in Children”. Journal of Pediatric Sciences 3/4 (November 2011), 1-15. https://doi.org/10.17334/jps.00191.
JAMA Ertem D. Helicobacter pylori infection in children. Journal of Pediatric Sciences. 2011;3:1–15.
MLA Ertem, Deniz. “Helicobacter Pylori Infection in Children”. Journal of Pediatric Sciences, vol. 3, no. 4, 2011, pp. 1-15, doi:10.17334/jps.00191.
Vancouver Ertem D. Helicobacter pylori infection in children. Journal of Pediatric Sciences. 2011;3(4):1-15.