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Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia

Year 2015, Volume: 7 , - , 07.01.2015

Abstract

Background:Cardiovascular events and complications are the leading causes of mortality and morbidity in patients with sickle cell anemia (SCA). Early identification of ventricular dysfunction, before the appearance of symptoms, can alter the prognosis by optimizing   therapy. This study aimed at clarifying the value of Real Time 3D Echocardiography (RT3DE ) in early detection of regional   myocardial dysfunction in those patients before the development of overt cardiomyopathy.

Methods: This is an observational cross sectional study that was carried out on 60 children divided into 2 groups; Group 1 included 30 children with SCA, Group 2:  30 children matched for age and sex as a control group. For all children: ethically committee approval and informed consent from the parents or their guardians was obtained. All Children with SCA under  the age  of 15 who  do not show any signs or symptoms of heart failure were included in this study . Any child with present or past history of heart failure or any child with associated congenital or acquired heart diseases was excluded from the study. All children with systemic diseases that may affect cardiac structure and function have been also excluded. All the children were subjected to through clinical evaluation for any signs of heart failure, Echocardiography studies  , included M mode , Tissue Doppler  and 4D echo for assessment of left  ventricle.

Statistical analysis    : IBM SPSS statistics was used for data analysis.  Data were expressed as Mean ±SD. t test was used for differences in the variables between patients and control. Pearson correlation test   was used   for possible association between each two variables. Statistical significance was defined as a p value < 0.05.

Results: TDI showed left ventricular systolic and diastolic dysfunction in SCA compared with the control. RT3DE was   a sensitive tool to   detect   an  increase in  LVEF  . There was no significant LV enlargement through LV LSS and DSI in our cohort. There was no significant relation between hemoglobin level and different echo parameters in the studied groups.

Conclusion:RT3DE with tissue Doppler technique are promising tools for early detection of regional systolic or diastolic dysfunction of left ventricle in children with SCA.

 

 

References

  • 1- El Beshlawy A, Kaddah N, Ragab L, et al.: Sickle cell disease in Egyptian children the first inter. Abstract book. Convention Center, Alexandria, Egypt, 1996; 24-26.
  • 2- Lester LA, Sodt PC, Hutcheon N, Arcilla RA. Cardiac abnormalities in children with sickle cell anemia. Chest 1990;98: 1169 –74.
  • 3- Batra AS, Acherman RJ, Wong WY, Wood JC, Chan LS, Ramicone E, et al. Cardiac abnormalities in children with sickle cell anemia. J Am Hematol 2002; 70: 306–312.
  • 4- Myerson SG, Montgomery HE, World MJ, Pennell DJ. Left ventricular mass: reliability of echocardiographic formulas. Hypertension 2002;40: 673–8. 2-dimensional
  • 5- Bu L, Munns S and Zhang H, Disterhoft M, Dixon M, Stolpen A, Sonka M, Scholz TD. Rapid full volume data acquisition by real- time 3-dimensional echocardiography for assessment of left ventricular indexes in children: a validation study compared with magnetic resonance imaging. J Am Soc Echocardiogra 2005;18:299–305.
  • 6- Jenkins C, Bricknell K, Hanekom L, Morwick TH. Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real time three- dimensional echocardiography. J Am Coll Cardiol 2004; 44: 878–86.
  • 7- Tsironi M, Aessopos A. The heart in sickle cell disease. Acta Cardiol 2005;60:589-598.
  • 8- Kato GJ, Onyekwere OC, Gladwin MT. Pulmonary hypertension in sickle cell disease: relevance to children. Pediatr Hematol Oncol.2007;24:159-170.
  • 9- Mannearts HFJ, Van Der Heide JA, Kamp O, et al. Early identification of left ventricular remodeling after myocardial infarction, assessed echocardiography. Eur Heart J 2004; 28:68
  • 10- Dokainish H, Sengupta R, Pillai M, Bobek J, Lakkis N. Assessment of left ventricular systolic function using echocardiography in patients with preserved ejection fraction and elevated diastolic pressures. Am J Cardiol. 2008; 101(12):1766-71.
  • 11- Caldas MC, Meira ZA, Barbosa MM. Evaluation of 107 patients with sickle cell anemia myocardial performance index. J Am Soc Echocardiogr 2008;21:1163–7. and dimensional echocardiographic in indexes a normal
  • 18- Takeuchi M, Jacobs A, Sugeng L, Nishikage T, Nakai H et.al. Assessment of left ventricular dyssynchrony with real-time 3- dimensional echocardiography: comparison with Doppler tissue imaging. J Am Soc Echocardiogr. 2007; 20: 1321–1329.
  • 19- Kapetanakis S, Kearney MT, Siva A, Gall N, Cooklin M, Monaghan MJ. Real-time three- dimensional echocar-diography: a novel technique to quantify global left ventricular mechanical dyssynchrony. Circulation. 2005; 112: 992–1000.
  • 20- Covitz W, Espeland M, Gallagher D, et al. The heart in sickle cell anemia. The cooperative study of sickle cell disease (CSSCD). Chest 1995;108:1214-9.
Year 2015, Volume: 7 , - , 07.01.2015

Abstract

References

  • 1- El Beshlawy A, Kaddah N, Ragab L, et al.: Sickle cell disease in Egyptian children the first inter. Abstract book. Convention Center, Alexandria, Egypt, 1996; 24-26.
  • 2- Lester LA, Sodt PC, Hutcheon N, Arcilla RA. Cardiac abnormalities in children with sickle cell anemia. Chest 1990;98: 1169 –74.
  • 3- Batra AS, Acherman RJ, Wong WY, Wood JC, Chan LS, Ramicone E, et al. Cardiac abnormalities in children with sickle cell anemia. J Am Hematol 2002; 70: 306–312.
  • 4- Myerson SG, Montgomery HE, World MJ, Pennell DJ. Left ventricular mass: reliability of echocardiographic formulas. Hypertension 2002;40: 673–8. 2-dimensional
  • 5- Bu L, Munns S and Zhang H, Disterhoft M, Dixon M, Stolpen A, Sonka M, Scholz TD. Rapid full volume data acquisition by real- time 3-dimensional echocardiography for assessment of left ventricular indexes in children: a validation study compared with magnetic resonance imaging. J Am Soc Echocardiogra 2005;18:299–305.
  • 6- Jenkins C, Bricknell K, Hanekom L, Morwick TH. Reproducibility and accuracy of echocardiographic measurements of left ventricular parameters using real time three- dimensional echocardiography. J Am Coll Cardiol 2004; 44: 878–86.
  • 7- Tsironi M, Aessopos A. The heart in sickle cell disease. Acta Cardiol 2005;60:589-598.
  • 8- Kato GJ, Onyekwere OC, Gladwin MT. Pulmonary hypertension in sickle cell disease: relevance to children. Pediatr Hematol Oncol.2007;24:159-170.
  • 9- Mannearts HFJ, Van Der Heide JA, Kamp O, et al. Early identification of left ventricular remodeling after myocardial infarction, assessed echocardiography. Eur Heart J 2004; 28:68
  • 10- Dokainish H, Sengupta R, Pillai M, Bobek J, Lakkis N. Assessment of left ventricular systolic function using echocardiography in patients with preserved ejection fraction and elevated diastolic pressures. Am J Cardiol. 2008; 101(12):1766-71.
  • 11- Caldas MC, Meira ZA, Barbosa MM. Evaluation of 107 patients with sickle cell anemia myocardial performance index. J Am Soc Echocardiogr 2008;21:1163–7. and dimensional echocardiographic in indexes a normal
  • 18- Takeuchi M, Jacobs A, Sugeng L, Nishikage T, Nakai H et.al. Assessment of left ventricular dyssynchrony with real-time 3- dimensional echocardiography: comparison with Doppler tissue imaging. J Am Soc Echocardiogr. 2007; 20: 1321–1329.
  • 19- Kapetanakis S, Kearney MT, Siva A, Gall N, Cooklin M, Monaghan MJ. Real-time three- dimensional echocar-diography: a novel technique to quantify global left ventricular mechanical dyssynchrony. Circulation. 2005; 112: 992–1000.
  • 20- Covitz W, Espeland M, Gallagher D, et al. The heart in sickle cell anemia. The cooperative study of sickle cell disease (CSSCD). Chest 1995;108:1214-9.
There are 14 citations in total.

Details

Primary Language English
Journal Section Original Articles
Authors

Osama Abdrab El Rassoul Tolba This is me

Mr El- Shanshory This is me

Wegdan Mawlana

Publication Date January 7, 2015
Published in Issue Year 2015 Volume: 7

Cite

APA Tolba, O. A. E. R., El- Shanshory, M., & Mawlana, W. (2015). Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia. Journal of Pediatric Sciences, 7. https://doi.org/10.17334/jps.79790
AMA Tolba OAER, El- Shanshory M, Mawlana W. Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia. Journal of Pediatric Sciences. January 2015;7. doi:10.17334/jps.79790
Chicago Tolba, Osama Abdrab El Rassoul, Mr El- Shanshory, and Wegdan Mawlana. “Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children With Sickle Cell Anemia”. Journal of Pediatric Sciences 7, January (January 2015). https://doi.org/10.17334/jps.79790.
EndNote Tolba OAER, El- Shanshory M, Mawlana W (January 1, 2015) Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia. Journal of Pediatric Sciences 7
IEEE O. A. E. R. Tolba, M. El- Shanshory, and W. Mawlana, “Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia”, Journal of Pediatric Sciences, vol. 7, 2015, doi: 10.17334/jps.79790.
ISNAD Tolba, Osama Abdrab El Rassoul et al. “Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children With Sickle Cell Anemia”. Journal of Pediatric Sciences 7 (January 2015). https://doi.org/10.17334/jps.79790.
JAMA Tolba OAER, El- Shanshory M, Mawlana W. Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia. Journal of Pediatric Sciences. 2015;7. doi:10.17334/jps.79790.
MLA Tolba, Osama Abdrab El Rassoul et al. “Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children With Sickle Cell Anemia”. Journal of Pediatric Sciences, vol. 7, 2015, doi:10.17334/jps.79790.
Vancouver Tolba OAER, El- Shanshory M, Mawlana W. Real Time 3-D Echocardiography for Evaluation of Left Ventricle in Children with Sickle Cell Anemia. Journal of Pediatric Sciences. 2015;7.