The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia

Indy Safitri; Yulia Yusrini Djabir; Firzan Nainu; Ismail Ismail; Nurul F. Supratman; Ririn Sriwahyuni

doi:10.12991/jrespharm.1797990

The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia

Abstract

Swamp eels (Monopterus albus), known for their high content of proteins, minerals, and vitamins, have potential therapeutic benefits for anemia. This study investigates the impact of swamp eel extract on hematological profiles and serum biomarkers in anemic rats induced by phenylhydrazine (PHZ). Using 96% ethanol, swamp eel extract was prepared and administered to twenty-four female rats divided into four groups: (1) Healthy control, (2) Placebo (PHZ only), (3) PHZ with 200 mg/kg extract, and (4) PHZ with 400 mg/kg extract. Anemia was induced by intraperitoneal PHZ injection over two days. Following confirmation of anemia, swamp eel extract was given orally for seven days. Blood samples were collected before PHZ injection (day 0), after PHZ injection (day 3), and after extract administration (day 10) to evaluate hematological profiles and serum biomarkers. Post-PHZ injection, all rats showed significant reductions in red blood cells (RBC), hemoglobin (Hb), and hematocrit (HCT), with increased leukocytes and altered serum biomarkers. After treatment with swamp eel extract, improvements were observed in hematological parameters, such as RBC, although some parameters were not statistically significant compared to the placebo control. The serum biomarkers such as serum glutamic-oxaloacetic transaminase (SGOT) and urea levels were also significantly improved.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Indy Safitri This is me
0009-0005-5600-8620
Indonesia

Yulia Yusrini Djabir ^*
0000-0002-5891-7247
Indonesia

Firzan Nainu
0000-0003-0989-4023
Indonesia

Ismail Ismail This is me
0000-0002-1137-5735
Indonesia

Nurul F. Supratman This is me
0009-0008-0815-3788
Indonesia

Ririn Sriwahyuni This is me
0009-0000-9448-2773
Indonesia

Publication Date

November 2, 2025

Submission Date

July 28, 2024

Acceptance Date

November 1, 2024

Published in Issue

Year 2025 Volume: 29 Number: 6

DOI

https://doi.org/10.12991/jrespharm.1797990

IZ

https://izlik.org/JA73UM93TF

Cite

RIS / Bibtex

APA

Safitri, I., Djabir, Y. Y., Nainu, F., Ismail, I., Supratman, N. F., & Sriwahyuni, R. (2025). The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia. Journal of Research in Pharmacy, 29(6), 2519-2526. https://doi.org/10.12991/jrespharm.1797990

AMA

1.Safitri I, Djabir YY, Nainu F, Ismail I, Supratman NF, Sriwahyuni R. The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia. J. Res. Pharm. 2025;29(6):2519-2526. doi:10.12991/jrespharm.1797990

Chicago

Safitri, Indy, Yulia Yusrini Djabir, Firzan Nainu, Ismail Ismail, Nurul F. Supratman, and Ririn Sriwahyuni. 2025. “The Effect of Swamp Eel (Monopterus Albus) Extract on Hematology Profiles and Organ Function of Rats With Phenylhydrazine-Induced Anemia”. Journal of Research in Pharmacy 29 (6): 2519-26. https://doi.org/10.12991/jrespharm.1797990.

EndNote

Safitri I, Djabir YY, Nainu F, Ismail I, Supratman NF, Sriwahyuni R (November 1, 2025) The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia. Journal of Research in Pharmacy 29 6 2519–2526.

IEEE

[1]I. Safitri, Y. Y. Djabir, F. Nainu, I. Ismail, N. F. Supratman, and R. Sriwahyuni, “The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia”, J. Res. Pharm., vol. 29, no. 6, pp. 2519–2526, Nov. 2025, doi: 10.12991/jrespharm.1797990.

ISNAD

Safitri, Indy - Djabir, Yulia Yusrini - Nainu, Firzan - Ismail, Ismail - Supratman, Nurul F. - Sriwahyuni, Ririn. “The Effect of Swamp Eel (Monopterus Albus) Extract on Hematology Profiles and Organ Function of Rats With Phenylhydrazine-Induced Anemia”. Journal of Research in Pharmacy 29/6 (November 1, 2025): 2519-2526. https://doi.org/10.12991/jrespharm.1797990.

JAMA

1.Safitri I, Djabir YY, Nainu F, Ismail I, Supratman NF, Sriwahyuni R. The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia. J. Res. Pharm. 2025;29:2519–2526.

MLA

Safitri, Indy, et al. “The Effect of Swamp Eel (Monopterus Albus) Extract on Hematology Profiles and Organ Function of Rats With Phenylhydrazine-Induced Anemia”. Journal of Research in Pharmacy, vol. 29, no. 6, Nov. 2025, pp. 2519-26, doi:10.12991/jrespharm.1797990.

Vancouver

1.Indy Safitri, Yulia Yusrini Djabir, Firzan Nainu, Ismail Ismail, Nurul F. Supratman, Ririn Sriwahyuni. The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia. J. Res. Pharm. 2025 Nov. 1;29(6):2519-26. doi:10.12991/jrespharm.1797990