Spanelastic as a vesicular nanocarrier for transdermal drug delivery system: Preparation, characterization and bioactive loading

Year 2025, Volume: 29 Issue: 2, 833 - 840

Nawal Ayash Rajab Yassir Mohamed Adulhussein Enas Jawad Kadhim Shaimaa Nazar Abdulhamid Enas Al-ani

https://doi.org/10.12991/jrespharm.1666368

Abstract

Spanlastic is a novel surfactant-based elastic nanovesicle delivery system that has been shown to deliver many different types of drugs. The present review aimed to illustrate the structure, composition, evaluation and discuss some bioactive compounds that can be delivered by spanlastics. Spanlastics are composed of a non-ionic surfactant and an edge activator, which gives them their elasticity. This elasticity allows spanlastics to deform and squeeze through the skin pores, making them ideal for transdermal delivery. Spanlastics have also been shown to be effective in delivering drugs to the eye, buccal mucosa, and other tissues. Spanlastics have several advantages over other drug delivery systems. They are non-immunogenic, biodegradable, and chemically stable. They are also more elastic than liposomes, which makes them more effective at penetrating biological membranes. In addition, spanlastics can be formulated to target specific tissues, which can improve the therapeutic efficacy of the drug. Spanlastics are a promising new drug delivery system with a wide range of potential applications. They are currently being investigated for the treatment of a wide range of diseases, including cancer, inflammation, and infectious diseases. Finally, this review leads to a conclude that Spanelastic can be used as a good Vesicular Nanocarrier for transdermal drug delivery system.

Keywords

Spanelastic, vesicular nanocarrier, transdermal drug delivery, olive tree, curcumin, green tea

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