Pharmacokinetic and biochemical properties of clindamycin compared with imipenem loaded bone cement

Year 2025, Volume: 29 Issue: 5, 1930 - 1939, 01.09.2025

Ban M. Ali Orooba M. S. Ibrahim Nibras N.a. Alabbas

https://doi.org/10.12991/jrespharm.1763621

Abstract

Bone cement is consider as a medical material used to anchor implants to bone in orthopedic and surgical
procedures. It is commonly made of polymethyl methacrylate (PMMA), a biocompatible substance that provides
mechanical stability. The objective of this study is to examine the elution and biomechanical properties of antibiotics-
loaded bone cement. The groups of experiment include, Antibiotic-free bone cement and bone cement containing 5%,
10%, 15%, and 1% of imipenen and Clindamycin, respectively. A total of 35 specimens for compression and tensile
testing were acquired. The drug concentration-time curve of imipenem (IMP) and clindamycin was constructed after the
eluent drug concentration was measured at 24, 48, 72 h, and 6, 12, and 24 days. All bone cement samples surpassed the
ISO 5833 standard for compressive strength (minimum 70 MPa). Clindamycin-loaded cements had higher compressive
and tensile strength values compared to IMP -loaded and antibiotic-free cements, particularly at 10% and 15% drug
concentrations, Clindamycin-loaded bone cement showed superior elution properties, releasing the drug more
consistently over 24 days compared to IMP, which had a rapid release in the first 72 hours and a sharp decline afterward.
Clindamycin demonstrated greater antibacterial potency against Pseudomonas aeruginosa than IMP, as shown by larger
zones of inhibition in agar diffusion assays. Regarder to antibiotic elution, IMP concentrations dropped significantly
after 72 hours, while clindamycin maintained a steadier release profile, offering prolonged antibacterial coverage.At the
end of 24 days, clindamycin showed a threefold higher cumulative release compared to IMP. In conclusion,
Clindamycin-loaded bone cement showed to be more effective than IMP in terms of sustained drug release, mechanical
properties, and antibacterial activity, making it a promising choice for treating bone and joint infections.

Keywords

Polymethyl methacrylate , sensitivity , imipenem , clindamycin , mechanical properties , pharmacokinetic

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