The effect of swamp eel (Monopterus albus) extract on hematology profiles and organ function of rats with phenylhydrazine-induced anemia

Year 2025, Volume: 29 Issue: 6, 2519 - 2526, 02.11.2025

Indy Safitri Yulia Yusrini Djabir , Firzan Nainu , Ismail Ismail Nurul F. Supratman Ririn Sriwahyuni

https://doi.org/10.12991/jrespharm.1797990

Abstract

Swamp eels (Monopterus albus), known for their high content of proteins, minerals, and vitamins, have potential therapeutic benefits for anemia. This study investigates the impact of swamp eel extract on hematological profiles and serum biomarkers in anemic rats induced by phenylhydrazine (PHZ). Using 96% ethanol, swamp eel extract was prepared and administered to twenty-four female rats divided into four groups: (1) Healthy control, (2) Placebo (PHZ only), (3) PHZ with 200 mg/kg extract, and (4) PHZ with 400 mg/kg extract. Anemia was induced by intraperitoneal PHZ injection over two days. Following confirmation of anemia, swamp eel extract was given orally for seven days. Blood samples were collected before PHZ injection (day 0), after PHZ injection (day 3), and after extract administration (day 10) to evaluate hematological profiles and serum biomarkers. Post-PHZ injection, all rats showed significant reductions in red blood cells (RBC), hemoglobin (Hb), and hematocrit (HCT), with increased leukocytes and altered serum biomarkers. After treatment with swamp eel extract, improvements were observed in hematological parameters, such as RBC, although some parameters were not statistically significant compared to the placebo control. The serum biomarkers such as serum glutamic-oxaloacetic transaminase (SGOT) and urea levels were also significantly improved.

Keywords

Swamp eel extract , hematological profiles , organ function , anemia model , phenylhydrazine

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