Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles

Halil Çolak

doi:10.56639/jsar.1758342

Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles

Abstract

Background: Skeletal muscle is increasingly recognized not only as a contractile organ responsible for movement but also as an active endocrine organ regulating systemic physiological processes. Myokines, biologically active proteins secreted during muscle contraction, are key mediators in metabolic homeostasis, immune regulation, neuroplasticity, and musculoskeletal health. This review aims to provide a comprehensive evaluation of the biochemical properties, target systems, and potential applications of major exercise-induced myokines. Methods: A multidisciplinary literature review was conducted, incorporating findings from exercise physiology, molecular biology, and clinical research. The analysis focused on Interleukin-6, Irisin, Brain-Derived Neurotrophic Factor, Myostatin, Insulin-Like Growth Factor-1, and Mechano Growth Factor, examining their secretion mechanisms, signaling pathways, and physiological effects. Results: Myokines were found to play significant roles in managing metabolic disorders, preventing age-related muscle loss, supporting rehabilitation processes, and monitoring athletic performance. Their effects extend beyond skeletal muscle, impacting cardiovascular, neural, and immune systems. Conclusions: Understanding the endocrine role of skeletal muscle, the diverse actions of myokines offer promising opportunities to integrate exercise science into clinical medicine. Personalized exercise prescriptions based on myokine profiles, supported by biotechnological innovations, may enhance preventive and therapeutic strategies, bridging the gap between basic science and applied health interven-tions.

Keywords

References

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Details

Primary Language

English

Subjects

Exercise Physiology, Physical Activity and Health, Sports Science and Exercise (Other)

Journal Section

Review Article

Authors

Halil Çolak ^*
0000-0001-9003-106X
Türkiye

Early Pub Date

December 15, 2025

Publication Date

December 30, 2025

Submission Date

August 4, 2025

Acceptance Date

December 14, 2025

Published in Issue

Year 2025 Volume: 7 Number: 4

DOI

https://doi.org/10.56639/jsar.1758342

IZ

https://izlik.org/JA38CT82AJ

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RIS / Bibtex

APA

Çolak, H. (2025). Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles. Journal of Sport for All and Recreation, 7(4), 788-799. https://doi.org/10.56639/jsar.1758342

AMA

1.Çolak H. Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles. JSAR. 2025;7(4):788-799. doi:10.56639/jsar.1758342

Chicago

Çolak, Halil. 2025. “Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles”. Journal of Sport for All and Recreation 7 (4): 788-99. https://doi.org/10.56639/jsar.1758342.

EndNote

Çolak H (December 1, 2025) Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles. Journal of Sport for All and Recreation 7 4 788–799.

IEEE

[1]H. Çolak, “Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles”, JSAR, vol. 7, no. 4, pp. 788–799, Dec. 2025, doi: 10.56639/jsar.1758342.

ISNAD

Çolak, Halil. “Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles”. Journal of Sport for All and Recreation 7/4 (December 1, 2025): 788-799. https://doi.org/10.56639/jsar.1758342.

JAMA

1.Çolak H. Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles. JSAR. 2025;7:788–799.

MLA

Çolak, Halil. “Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles”. Journal of Sport for All and Recreation, vol. 7, no. 4, Dec. 2025, pp. 788-99, doi:10.56639/jsar.1758342.

Vancouver

1.Halil Çolak. Myokines in Response to Exercise: Endocrine Function and Systemic Effects of Muscles. JSAR. 2025 Dec. 1;7(4):788-99. doi:10.56639/jsar.1758342