Abstract
There are some structural and chemical similarities between metallocene dihalide [M(η5-Cp)2X2] and the cis-diaminedichloroplatin(II) complex, which is very well known as a tumor agent. Studies have shown that the biochemical behavior of metallocenes is different and it has been determined that it has an antitumor effect incidentally. It has been observed that metallocene dihalide compounds have high activity against tumor cells. The most important evidence for this is metal ion accumulation in tumor cells. As a result of biochemical studies, it has been determined that the activity of metallocene complexes is strongly affected by the central ion. It was observed that the separation of cyclopentadienyl (Cp) ligand from the structure varies depending on the metal ion and the pH of the solution. For example, while it was detected that the cyclopentadienyl ring was separated from the structure in the Ti4+ complex, this was not observed in the V4+ complex. Accordingly, it has been determined that the biological activities of these complexes differ. In this review, information is given on the chemical structure of metallocenes, the synthesis of metallocene complexes and their use in medicine in cancer treatment.
Keywords
References
- Antonio, T. (1995). Ferrocenes: Homogeneous Catalysis, Organic Synthesis, Materials Science
- Brennan, J. G., Andersen, R. A., Zalkin, A. Chemistry of trivalent uranium metallocenes: electron-transfer reactions. Synthesis and characterization of [(MeC5H4)3U]2E (E = S, Se, Te) and the crystal structures of hexakis(methylcyclopentadienyl)sulfidodiuranium and tris(methylcyclopentadienyl)(triphenylphosphine oxide)uranium 1986;25(11):1761-1765
- Claffey, J., Müller-Bunz, H., Tacke, M., 2010. Benzyl-susbstitued titanocene dichloride anticancer drugs: From lead to hit. Journal of Organometallic Chemistry, 2010
- Honzicek, J., Erben, M., Cisarova, I., Vinklarek, J., 2005. Synthesis, characterization and structure of metallocene dicyanamide complexes, Inorganica chimica acta,
- Köpf, H., Köpf-Maier, P., 1979 Titanocene Dichloride,The First Metallocene with Cancerostatic Activity, This work was supported by the Fonds der Chemischen Industrie
- Lippard, S. J., 1987. Platinum, gold, and other metal chemotherapeutic agents: chemistry and biochemistry
- Reishus, J. W., Martin, D. S., 1961 cis-Dichlorodiammineplatinum(II). Acid Hydrolysis and Isotopic Exchange of the Chloride Ligands, Journal of the American Chemical
- Sanna, D., Ugone, V., Micerena, G., Pivetta, T., Valletta, E., 2015. Speciation of the potential antitumor agent Vanadocene Dichloride in the blood plasma and model systems.
- Roberts, J. J., Thomson, A. J., 1979. Platinium Coordination Complexes in chemotheraphy.
- Wilkonson, G., Birmingham, J. M., 1954. Bis-cyclopentadienyl compounds of Ti, Zr, V, Nb and Ta
- Wiley-Blackwell, 1998., Long NJ. Metallocenes: Introduction to Sandwich Complexes. London
Abstract
Metalosen dihalojenür [M(η5-Cp)2X2] ile çok iyi tümör ajanı olarak bilinen cis-diamindikloroplatin(II) kompleksi arasında bazı yapı ve kimyasal benzerlikler vardır. Yapılan çalışmalar metalosenlerin biyokimyasal davranışlarının farklı olduğunu ortaya koymuş ve tesadüfi olarak antitümör etkisi gösterdiği belirlenmiştir. Metolasen dihalojenür bileşiklerinin, tümör hücrelerine karşı yüksek aktiviteye sahip olduğu gözlenmiştir. Bunun en önemli kanıtı olarak, tümör hücrelerindeki metal iyonu birikimi gösterilmiştir. Biyokimyasal araştırmalar sonucunda metalosen komplekslerinin aktivitesinin merkez iyonundan güçlü bir şekilde etkilendiği tespit edilmiştir. Siklopentadienil (Cp) ligandının yapıdan ayrılmasının metal iyonuna ve çözeltinin pH’sına bağlı olarak değiştiği gözlenmiştir. Örneğin, Ti4+ kompleksinde siklopentadienil halkasının yapıdan ayrıldığı tespit edilirken, V4+ kompleksinde bu durum gözlenmemiştir. Buna bağlı olarak da bu komplekslerin biyolojik aktivitelerinin farklılık gösterdiği belirlenmiştir. Bu derlemede metalosenlerin kimyasal yapısı, metalosen komplekslerinin sentezlenmesi ve tıpta kanser tedavisinde kullanımı üzerine bilgi verilmektedir.
Keywords
References
- Antonio, T. (1995). Ferrocenes: Homogeneous Catalysis, Organic Synthesis, Materials Science
- Brennan, J. G., Andersen, R. A., Zalkin, A. Chemistry of trivalent uranium metallocenes: electron-transfer reactions. Synthesis and characterization of [(MeC5H4)3U]2E (E = S, Se, Te) and the crystal structures of hexakis(methylcyclopentadienyl)sulfidodiuranium and tris(methylcyclopentadienyl)(triphenylphosphine oxide)uranium 1986;25(11):1761-1765
- Claffey, J., Müller-Bunz, H., Tacke, M., 2010. Benzyl-susbstitued titanocene dichloride anticancer drugs: From lead to hit. Journal of Organometallic Chemistry, 2010
- Honzicek, J., Erben, M., Cisarova, I., Vinklarek, J., 2005. Synthesis, characterization and structure of metallocene dicyanamide complexes, Inorganica chimica acta,
- Köpf, H., Köpf-Maier, P., 1979 Titanocene Dichloride,The First Metallocene with Cancerostatic Activity, This work was supported by the Fonds der Chemischen Industrie
- Lippard, S. J., 1987. Platinum, gold, and other metal chemotherapeutic agents: chemistry and biochemistry
- Reishus, J. W., Martin, D. S., 1961 cis-Dichlorodiammineplatinum(II). Acid Hydrolysis and Isotopic Exchange of the Chloride Ligands, Journal of the American Chemical
- Sanna, D., Ugone, V., Micerena, G., Pivetta, T., Valletta, E., 2015. Speciation of the potential antitumor agent Vanadocene Dichloride in the blood plasma and model systems.
- Roberts, J. J., Thomson, A. J., 1979. Platinium Coordination Complexes in chemotheraphy.
- Wilkonson, G., Birmingham, J. M., 1954. Bis-cyclopentadienyl compounds of Ti, Zr, V, Nb and Ta
- Wiley-Blackwell, 1998., Long NJ. Metallocenes: Introduction to Sandwich Complexes. London
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Review |
| Authors | |
| Publication Date | April 29, 2022 |
| Submission Date | December 1, 2021 |
| Published in Issue | Year 2022 |
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