“Double test screening values: Are they different in IVF and spontaneous pregnancies ?”

Year 2019, Volume: 4 Issue: 2, 53 - 59, 25.12.2019

Ömür Keskin Murat Alan Yasemin Alan , Emrah Töz

Abstract

Objective:  To compare the IVF pregnancy group and
spontaneous pregnancy group in terms of PAPP-A and free β-hCG

Materials and methods:

 Among the pregnant women who applied for
double test screening between September 2017 and September 2018, 42 singleton
pregnancies that were pregnant as a result of IVF (in vitro fertilization)
constituted our study group where 109 singleton pregnancies whose age range
were matching the IVF pregnacies but were pregnant spontaneously without any
assisted reproductive technologies (ART) remained in our control group. The
demographic data and pregnancy outcomes of both pregnancies were similar.

Findings:

The mean PAPP-A (pregnancy
associated plasma protein-A) was found in the control group (2.82 mlU / ml;
0.97 MoM), while in the study group 2.41 mlU / ml, 0.94 MoM). Free β-hCG
(beta-human chorionic gonadotropin) values were found as 46.44, ng / ml;
1.21MoM, 53.79ng / ml in control and study groups respectively. The mean PAPP-A
of the IVF pregnancy group was lower than the spontaneous pregnancy group, and
the mean β-hCG was higher than the spontaneous pregnancy group, but these
differences were not statistically significant (p> 0.005). Although not
statistically significant; In terms of trisomy 21 we evaluated the study group
as higher risk than the control group (p> 0.05).

Results: The mean of PAPP-A
and free β-hCG values are different in IVF and spontaneous pregnancies, and
these differences in biochemical parameters affect the risk of trisomy 21.

Keywords

: β-hCG, PAPP-A, IVF, spontaneous pregnancy

References

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