HİDRADENİTİS SUPURATİVA HASTALARINDA FOLİK ASİT VE HBA1C DEĞERLERİNİN KORELASYONU

Öz

Hidradenitis supurativa (HS) esasen folikülopilosebase üniteyi etkileyen, özellikle aksillar , inguinal , perianal, genital ve inframamarian gibi apokrin bezden zengin deri bölgelerini tutan kronik, ağrılı , folliküler, okluziv kutanöz bir hastalıktır. HS patogenezi tam olarak anlaşılamamıştır. Bağışıklık sisteminin disregülasyonu HS etyolojisine katkıda bulunabilir. Genetik, diyet, sigara kullanımı, obezite, mekanik travma ve hormonal faktörler HS ile ilişkili olabilir. Rektospektif çalışmamızda hastalarımızda HS’ye eşlik eden faktörler olarak daha önce birkaç yazıda bahsedilen diyabet ve folik asit eksikliği ile ilgili verileri gözden geçirmeyi amaçladık. Çalışmamızda 24 hastanın 1/3'ünde HbA1c seviyesinin yüksek olduğu, sadece 4 hastada folik asit seviyesinin istenilen değerde olduğu saptandı. Bu sınırlı sayıdaki veri, bu konuda daha fazla çalışma yapılması fikrini destekler niteliktedir.

Anahtar Kelimeler

• folik asit
• hidradenitis supurativa
• HbA1c

HBA1C AND FOLIC ACID VALUES IN PATIENTS WITH HYDRADENITIS SUPURATIVA

Abstract

Hidradenitis supurativa (HS) is a chronic, follicular and occlusive cutaneous disease that mainly affects the folliculopilosebaceous unit, especially in areas of skin which is rich in apocrine glands such as axillary, inguinal, perianal, genital and inframammary regions. The pathogenesis of HS is not understood completely. Dysregulation of the immune system may contribute to HS etiology. Genetics, diet, smoking, obesity, mechanical trauma hormonal factors may be associated with HS (1,2). In our retrospective study, we aimed to review the data on diabetes and folic acid deficiency, which were mentioned in a few articles before, as factors accompanying HS in our patients. We found that 1/3 of 24 patients had high HbA1c levels, and folic acid levels were at the desired value in only four patients. This limited number of data seems to support the idea of further studies on this subject.

Keywords

• folic acid
• hydradenitis supurativa
• HbA1c

References

1. Referans1. Wolff, Klaus, et al. Fitzpatrick’s Color Atlas AND SYNOPSIS OF CLINICAL DERMATOLOGY, 8th Ed. 8th ed., McGraw Hill / Medical, 2017.
2. Referans2. Kurzen H, Kurokawa I, Jemec GB, et al. What causes hidradenitis suppurativa? Exp Dermatol 2008; 17: 455.
3. Referans3. Bolognia, J., Jorizzo, J. L., Rapini, R. P., Hayriye Sarıcaoğlu, & Emel Bülbül Başkan. (2012). Dermatoloji. Nobel Tıp.
4. Referans4. Wolkenstein P, Loundou A, Barrau K, Auquier P, Revuz J; Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: a study of 61 cases. J Am Acad Dermatol. 2007 Apr;56(4):621-3. doi: 10.1016/j.jaad.2006.08.061. Epub 2006 Oct 20. PMID: 17097366.
5. Referans5. Senthilnathan A, Kolli SS, Cardwell LA, Richardson IM, Feldman SR, Pichardo RO. Even mild hidradenitis suppurativa impairs quality of life. Br J Dermatol. 2019 Oct;181(4):838-839. doi: 10.1111/bjd.17928. Epub 2019 Jun 2. PMID: 30916383.
6. Referans6. Hurley HJ. Axillary hyperhidrosis, apocrine bromhidrosis, hidradenitis suppurativa, and familial benign pemphigus: Surgical approach. In: Dermatologic Surgery, Roenigk RK, Roenigk HH (Eds), Dekker, 1989. p.729.
7. Referans7. Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)--a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994 May;19(3):210-6. doi: 10.1111/j.1365-2230.1994.tb01167.x. PMID: 8033378.
8. Referans8. Chren MM, Lasek RJ, Sahay AP, Sands LP. Measurement properties of Skindex-16: a brief quality-of-life measure for patients with skin diseases. J Cutan Med Surg. 2001 Mar-Apr;5(2):105-10. doi: 10.1007/BF02737863. Epub 2001 Mar 21. PMID: 11443481.

9. Referans9. Sartorius K, Emtestam L, Jemec GB, Lapins J. Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. Br J Dermatol. 2009 Oct;161(4):831-9. doi: 10.1111/j.1365-2133.2009.09198.x. Epub 2009 Apr 29. PMID: 19438453.
10. Referans10. Ellis LZ. Hidradenitis suppurativa: surgical and other management techniques. Dermatol Surg. 2012 Apr;38(4):517-36. doi: 10.1111/j.1524-4725.2011.02186.x. Epub 2011 Oct 14. PMID: 22092698.
11. Referans11. Bui TL, Silva-Hirschberg C, Torres J, Armstrong AW. Hidradenitis suppurativa and diabetes mellitus: A systematic review and meta-analysis. J Am Acad Dermatol. 2018. doi: 10.1016/j.jaad.2017.08.042
12. Referans12. Donnarumma, M., Marasca, C., Palma, M., Vastarella, M., Annunziata, M. C., & Fabbrocini, G. (2020). An oral supplementation based on myo-inositol, folic acid and liposomal magnesium may act synergistically with antibiotic therapy and can improve metabolic profile in patients affected by Hidradenitis suppurativa: our experience. Giornale Italiano Di Dermatologia E Venereologia: Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia, 155(6), 749–753. https://doi.org/10.23736/S0392-0488.18.06012-1- Ahmad, S., Riddle, A. O., & Sayed, C. J. (2021). Outcomes of Routine Diabetes Screening for Patients with Hidradenitis Suppurativa. The Journal of Investigative Dermatology, 141(4), 927–930.