DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Year 2018, Volume: 2 Issue: 1, 1 - 8, 31.01.2018

Elif Uğurlu Sultan Yağmur , Selehattin Yılmaz

Abstract

DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Abstract

In this study, electroanalytical technique was
developed for the quantitative analysis of clomipramine hydrochloride from its
commercial tablet dosage forms based on its oxidation behavior. The
electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon
electrode (GCE) by two voltammetric techniques. 
The electrochemical measurements were carried out on GCE surface in
different buffer solutions in the pH range from 2.00 to 12.00 by cyclic
voltammetry (CV) and differential pulse voltammetry (DPV) techniques.  The effect of pH on the anodic peak current
and peak potential was investigated. Phosphate buffer (pH 6.50) was selected
for analytical purposes.  The
diffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysis
was constructed in the clozapine concentration range from 5x10^-6 mol
L^-1 to 3x10^-5 mol L^-1. Limit of detection
(LOD) and limit of quantification (LOQ) were obtained as 2.8x10^-7
mol L^-1 and 8.4x10^-7 mol L^-1 respectively. 

Keywords

clomipramine hydrochloride, oxidation, voltammetry, GCE

References

• REFERENCES
• BIOSHIP, E., HUSSEIN, W.,1984, Electroanalytical study of tricyclic antidepressants, Analyst, 109, 73-80. ÇITAK, M., YILMAZ, S., DILGIN, Y., TÜRKER, G., YAĞMUR, S., ERDUGAN, H., 2007, Osteryoung square wave voltammetric determination of phenazopyridine hydrochloride in human urine and tablet dosage forms based on electrochemical reduction at carbon paste electrode.Current Pharmaceutical Analysis, 3, 141-145. EKER, R., YILMAZ, S., YAĞMUR, S., TONGUC YAYINTAS, O., 2017, Voltammetric determination of clozapine from its drug form. Journal of Scientific Perspectives, 2, 19-30. GUIYING, Y., JIN, F., L. KONG, J., 2007, Sensitive Determination of Clomipramine at Poly-ABSA/Pt Nano-Clusters Modified Gşassy Carbon Electrode. Analytical Letters, 40(18), 3392-3404 HUANG, F., QU, S., ZHANG, S., LIU, B., Kong D, J., 2008, Sensitive voltammetric detection of clomipramine at 16-mercaptohexadecanoic acid self-assembled monolayer modified gold electrode. Microchimica Acta, 161, 149-155. IVANDIDI, TA.,SARADA, BV., TERASHIMA, C., RAO, TN.,TRYK, DA., ISHIGURO, H., KUBOTA, Y., FUJISHIMA, A., 2002, Electrochemical detection of tricyclic antidepressant drugs by HPLC using highly boron-doped diamond electrodes. J Electroanal Chem, 521, 117-126. ORTUNO, J A., HERNANDEZ, J., PEDRENO, C S., 2006, Ion-selective electrode for the determination of some multidrug resistance reversers. Sens Actuators, B119, 282-287. SKRZYPEK, S., CIESIELSKI, W, SOKOLOWSKI, A., YILMAZ, S., KAZMIERCAK, D., 2005, TALANTA, 66, 1146-1151. YAGMUR, S., TURE, M., SAGLIKOGLU, G., SADIKOGLU, M.,YILMAZ, S., 2017, The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry, Journol of Russian electrochemistry (in press). YILMAZ, S., SADIKOGLU, M., SAGLIKOGLU, G., YILDIZ, M., YENGIN, C., KILINC, E., 2013, Electrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form, Int. J. Electrochem. Sci., 8, 6818-6828.