Year 2018, Volume 2 , Issue 1, Pages 1 - 8 2018-01-31

DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY
DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Elif UĞURLU [1] , Sultan YAĞMUR [2] , Selehattin YILMAZ [3]


In this study, electroanalytical technique was developed for the quantitative analysis of clomipramine hydrochloride from its commercial tablet dosage forms based on its oxidation behavior. The electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon electrode (GCE) by two voltammetric techniques.  The electrochemical measurements were carried out on GCE surface in different buffer solutions in the pH range from 2.00 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques.  The effect of pH on the anodic peak current and peak potential was investigated. Phosphate buffer (pH 6.50) was selected for analytical purposes.  The diffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysis was constructed in the clozapine concentration range from 5x10-6 mol L-1 to 3x10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 2.8x10-7 mol L-1 and 8.4x10-7 mol L-1 respectively. 

clomipramine hydrochloride, oxidation, voltammetry, GCE
  • REFERENCES
  • BIOSHIP, E., HUSSEIN, W.,1984, Electroanalytical study of tricyclic antidepressants, Analyst, 109, 73-80. ÇITAK, M., YILMAZ, S., DILGIN, Y., TÜRKER, G., YAĞMUR, S., ERDUGAN, H., 2007, Osteryoung square wave voltammetric determination of phenazopyridine hydrochloride in human urine and tablet dosage forms based on electrochemical reduction at carbon paste electrode.Current Pharmaceutical Analysis, 3, 141-145. EKER, R., YILMAZ, S., YAĞMUR, S., TONGUC YAYINTAS, O., 2017, Voltammetric determination of clozapine from its drug form. Journal of Scientific Perspectives, 2, 19-30. GUIYING, Y., JIN, F., L. KONG, J., 2007, Sensitive Determination of Clomipramine at Poly-ABSA/Pt Nano-Clusters Modified Gşassy Carbon Electrode. Analytical Letters, 40(18), 3392-3404 HUANG, F., QU, S., ZHANG, S., LIU, B., Kong D, J., 2008, Sensitive voltammetric detection of clomipramine at 16-mercaptohexadecanoic acid self-assembled monolayer modified gold electrode. Microchimica Acta, 161, 149-155. IVANDIDI, TA.,SARADA, BV., TERASHIMA, C., RAO, TN.,TRYK, DA., ISHIGURO, H., KUBOTA, Y., FUJISHIMA, A., 2002, Electrochemical detection of tricyclic antidepressant drugs by HPLC using highly boron-doped diamond electrodes. J Electroanal Chem, 521, 117-126. ORTUNO, J A., HERNANDEZ, J., PEDRENO, C S., 2006, Ion-selective electrode for the determination of some multidrug resistance reversers. Sens Actuators, B119, 282-287. SKRZYPEK, S., CIESIELSKI, W, SOKOLOWSKI, A., YILMAZ, S., KAZMIERCAK, D., 2005, TALANTA, 66, 1146-1151. YAGMUR, S., TURE, M., SAGLIKOGLU, G., SADIKOGLU, M.,YILMAZ, S., 2017, The Quantitative Detection of Phenylephrine in Pharmaceutical Preparations and Spiked Human Urine by Voltammetry, Journol of Russian electrochemistry (in press). YILMAZ, S., SADIKOGLU, M., SAGLIKOGLU, G., YILDIZ, M., YENGIN, C., KILINC, E., 2013, Electrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form, Int. J. Electrochem. Sci., 8, 6818-6828.
Primary Language en
Subjects Basic Sciences
Journal Section Research Article
Authors

Author: Elif UĞURLU
Country: Turkey


Author: Sultan YAĞMUR (Primary Author)
Institution: Çanakkale Onsekiz Mart University, Çanakkale, Turkey

Author: Selehattin YILMAZ
Institution: aCanakkale, Turkey, Canakkale Onsekiz Mart University, Faculty of Sciences and Arts,

Dates

Publication Date : January 31, 2018

Bibtex @research article { jsp410434, journal = {Journal of Scientific Perspectives}, issn = {}, eissn = {2587-3008}, address = {SARICAELI KÖYÜ ÇOMÜ SARICAELI YERLEŞKESI NO: 276 D-I, MERKEZ-ÇANAKKALE / TÜRKİYE}, publisher = {Rating Academy}, year = {2018}, volume = {2}, pages = {1 - 8}, doi = {}, title = {DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY}, key = {cite}, author = {Uğurlu, Elif and Yağmur, Sultan and Yılmaz, Selehattin} }
APA Uğurlu, E , Yağmur, S , Yılmaz, S . (2018). DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY . Journal of Scientific Perspectives , 2 (1) , 1-8 . Retrieved from https://dergipark.org.tr/en/pub/jsp/issue/36400/410434
MLA Uğurlu, E , Yağmur, S , Yılmaz, S . "DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY" . Journal of Scientific Perspectives 2 (2018 ): 1-8 <https://dergipark.org.tr/en/pub/jsp/issue/36400/410434>
Chicago Uğurlu, E , Yağmur, S , Yılmaz, S . "DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY". Journal of Scientific Perspectives 2 (2018 ): 1-8
RIS TY - JOUR T1 - DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY AU - Elif Uğurlu , Sultan Yağmur , Selehattin Yılmaz Y1 - 2018 PY - 2018 N1 - DO - T2 - Journal of Scientific Perspectives JF - Journal JO - JOR SP - 1 EP - 8 VL - 2 IS - 1 SN - -2587-3008 M3 - UR - Y2 - 2018 ER -
EndNote %0 Journal of Scientific Perspectives DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY %A Elif Uğurlu , Sultan Yağmur , Selehattin Yılmaz %T DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY %D 2018 %J Journal of Scientific Perspectives %P -2587-3008 %V 2 %N 1 %R %U
ISNAD Uğurlu, Elif , Yağmur, Sultan , Yılmaz, Selehattin . "DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY". Journal of Scientific Perspectives 2 / 1 (January 2018): 1-8 .
AMA Uğurlu E , Yağmur S , Yılmaz S . DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY. JSP. 2018; 2(1): 1-8.
Vancouver Uğurlu E , Yağmur S , Yılmaz S . DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY. Journal of Scientific Perspectives. 2018; 2(1): 1-8.