DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Year 2018, Volume: 2 Issue: 1, 1 - 8, 31.01.2018

Elif Uğurlu Sultan Yağmur Selehattin Yılmaz

Abstract

DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY

Abstract

In this study, electroanalytical technique was
developed for the quantitative analysis of clomipramine hydrochloride from its
commercial tablet dosage forms based on its oxidation behavior. The
electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon
electrode (GCE) by two voltammetric techniques. 
The electrochemical measurements were carried out on GCE surface in
different buffer solutions in the pH range from 2.00 to 12.00 by cyclic
voltammetry (CV) and differential pulse voltammetry (DPV) techniques.  The effect of pH on the anodic peak current
and peak potential was investigated. Phosphate buffer (pH 6.50) was selected
for analytical purposes.  The
diffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysis
was constructed in the clozapine concentration range from 5x10^-6 mol
L^-1 to 3x10^-5 mol L^-1. Limit of detection
(LOD) and limit of quantification (LOQ) were obtained as 2.8x10^-7
mol L^-1 and 8.4x10^-7 mol L^-1 respectively. 

Keywords

clomipramine hydrochloride, oxidation, voltammetry, GCE

References

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