Year 2018, Volume 2 , Issue 1, Pages 1 - 8 2018-01-31


Elif UĞURLU [1] , Sultan YAĞMUR [2] , Selehattin YILMAZ [3]

In this study, electroanalytical technique was developed for the quantitative analysis of clomipramine hydrochloride from its commercial tablet dosage forms based on its oxidation behavior. The electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon electrode (GCE) by two voltammetric techniques.  The electrochemical measurements were carried out on GCE surface in different buffer solutions in the pH range from 2.00 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques.  The effect of pH on the anodic peak current and peak potential was investigated. Phosphate buffer (pH 6.50) was selected for analytical purposes.  The diffusion-controlled nature of the peak was obtained.   A linear calibration plot for DPV analysis was constructed in the clozapine concentration range from 5x10-6 mol L-1 to 3x10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 2.8x10-7 mol L-1 and 8.4x10-7 mol L-1 respectively. 

clomipramine hydrochloride, oxidation, voltammetry, GCE
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Primary Language en
Subjects Basic Sciences
Journal Section Research Article

Author: Elif UĞURLU
Country: Turkey

Author: Sultan YAĞMUR (Primary Author)
Institution: Çanakkale Onsekiz Mart University, Çanakkale, Turkey

Author: Selehattin YILMAZ
Institution: aCanakkale, Turkey, Canakkale Onsekiz Mart University, Faculty of Sciences and Arts,


Publication Date : January 31, 2018

APA Uğurlu, E , Yağmur, S , Yılmaz, S . (2018). DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY . Journal of Scientific Perspectives , 2 (1) , 1-8 . Retrieved from