Year 2018, Volume 2 , Issue 1, Pages 39 - 48 2018-01-31

RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM

Oytun ERTAŞ [1] , Bengisu DÖNMEZ [2] , Sibel KONYALIOGLU [3] , Özlem SÖĞÜT [4]


Pinus Brutia Ten., traditionaly used as sugar regulator, antioxidant and antitumoral is consumed by chewing in Turkey. The aim of the study is to investigate the components and the effect of the gum. The base of the study depends on the way of comsumption of the resin. For in-vitro analysis, artificial salvia is used. The samples is stayed in artificial salvia at 37° C in ultrasonic bath for  different time period and then determined by U-HPLC, PDA detector. Three samples were prepared from each sample and three injections were made. Caffeic acid  was investigate in the samples. The optimum waiting period is set at 5 hours, which is considered to be a possible period since the  gum adheres to the tooth and is a hardly soluble substance. Considering the anticarcinogenic effect of caffeic acid, cytotoxic test was carried out on specimens which were kept in saliva for 24 hours acid. After incubation of the saliva extract that including 10, 20, 50 µM caffeic acid  in liver cancerous cells 1, 3, 6 hours, cell viability was observed.
Pinus brutia gum, salvia, UPLC
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Primary Language en
Subjects Pharmacology and Pharmacy
Journal Section Research Article
Authors

Author: Oytun ERTAŞ

Author: Bengisu DÖNMEZ

Author: Sibel KONYALIOGLU
Institution: Ege University, Faculty of Pharmacy, Department of Biochemistry, Bornova, İzmir
Country: Turkey


Author: Özlem SÖĞÜT (Primary Author)
Institution: Ege University, Faculty of Pharmacy, Department of Biochemistry, Bornova, İzmir

Dates

Publication Date : January 31, 2018

Bibtex @research article { jsp410518, journal = {Journal of Scientific Perspectives}, issn = {}, eissn = {2587-3008}, address = {SARICAELI KÖYÜ ÇOMÜ SARICAELI YERLEŞKESI NO: 276 D-I, MERKEZ-ÇANAKKALE / TÜRKİYE}, publisher = {Rating Academy}, year = {2018}, volume = {2}, pages = {39 - 48}, doi = {}, title = {RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM}, key = {cite}, author = {ERTAŞ, Oytun and DÖNMEZ, Bengisu and KONYALIOGLU, Sibel and SÖĞÜT, Özlem} }
APA ERTAŞ, O , DÖNMEZ, B , KONYALIOGLU, S , SÖĞÜT, Ö . (2018). RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM. Journal of Scientific Perspectives , 2 (1) , 39-48 . Retrieved from https://dergipark.org.tr/en/pub/jsp/issue/36400/410518
MLA ERTAŞ, O , DÖNMEZ, B , KONYALIOGLU, S , SÖĞÜT, Ö . "RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM". Journal of Scientific Perspectives 2 (2018 ): 39-48 <https://dergipark.org.tr/en/pub/jsp/issue/36400/410518>
Chicago ERTAŞ, O , DÖNMEZ, B , KONYALIOGLU, S , SÖĞÜT, Ö . "RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM". Journal of Scientific Perspectives 2 (2018 ): 39-48
RIS TY - JOUR T1 - RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM AU - Oytun ERTAŞ , Bengisu DÖNMEZ , Sibel KONYALIOGLU , Özlem SÖĞÜT Y1 - 2018 PY - 2018 N1 - DO - T2 - Journal of Scientific Perspectives JF - Journal JO - JOR SP - 39 EP - 48 VL - 2 IS - 1 SN - -2587-3008 M3 - UR - Y2 - 2018 ER -
EndNote %0 Journal of Scientific Perspectives RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM %A Oytun ERTAŞ , Bengisu DÖNMEZ , Sibel KONYALIOGLU , Özlem SÖĞÜT %T RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM %D 2018 %J Journal of Scientific Perspectives %P -2587-3008 %V 2 %N 1 %R %U
ISNAD ERTAŞ, Oytun , DÖNMEZ, Bengisu , KONYALIOGLU, Sibel , SÖĞÜT, Özlem . "RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM". Journal of Scientific Perspectives 2 / 1 (January 2018): 39-48 .
AMA ERTAŞ O , DÖNMEZ B , KONYALIOGLU S , SÖĞÜT Ö . RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM. JSP. 2018; 2(1): 39-48.
Vancouver ERTAŞ O , DÖNMEZ B , KONYALIOGLU S , SÖĞÜT Ö . RESEARCH ON THE COMPOSITION AND CYTOTOXIC ACTIVITY OF PINUS BRUTIA GUM. Journal of Scientific Perspectives. 2018; 2(1): 48-39.

Authors of the Article
Oytun ERTAŞ [1]
Bengisu DÖNMEZ [2]
Sibel KONYALIOGLU [3]
Özlem SÖĞÜT [4]