Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure

Mukaddes Keskinates; Bahar Yılmaz; Mevlüt Bayrakcı

doi:10.59313/jsr-a.1620817

Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure

Abstract

HEMA-based hydrogels were also developed and they were characterized for a few drugs including nifedipine, furosemide and niclosamide. The HEMA hydrogels were synthesized by functionalizing with methacrylated β−cyclodextrin monomer and then were tested in drug release studies. Antimicrobial study against bacteria: The pathogen was studied using disc diffusion and microdilution methods for the drug released from HEMA-based hydrogels. The hydrogel synthesized was found to have a very high capacity for absorption of water and it was also found that depending on this, the potential of drug absorption was also very high. In vitro, cumulative drug release studies on nifedipine, furosemide and niclosamide were carried out using hydrogel under various time and pH conditions. The released drug was adjustable as we obtained data on drug release profiles. Nifedipine, furosemide and niclosamide release percentages were 68.9±3.8%, 75.2±3.6% and 58.7±4.2%, respectively. Additionally, all three drugs exhibited marked activity against bacteria. These findings indicate that the synthesized hydrogels are a promising basis for biomedical applications.

Keywords

References

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Details

Primary Language

English

Subjects

Nanomedicine, Nanomaterials

Journal Section

Research Article

Authors

Mukaddes Keskinates ^*
0000-0002-1799-7180
Türkiye

Bahar Yılmaz
0000-0002-6315-3018
Türkiye

Mevlüt Bayrakcı
0000-0002-0416-2870
Türkiye

Publication Date

September 30, 2025

Submission Date

January 15, 2025

Acceptance Date

March 15, 2025

Published in Issue

Year 2025 Number: 062

DOI

https://doi.org/10.59313/jsr-a.1620817

IZ

https://izlik.org/JA97HF78RJ

Cite

RIS / Bibtex

APA

Keskinates, M., Yılmaz, B., & Bayrakcı, M. (2025). Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure. Journal of Scientific Reports-A, 062, 1-11. https://doi.org/10.59313/jsr-a.1620817

AMA

1.Keskinates M, Yılmaz B, Bayrakcı M. Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure. JSR-A. 2025;(062):1-11. doi:10.59313/jsr-a.1620817

Chicago

Keskinates, Mukaddes, Bahar Yılmaz, and Mevlüt Bayrakcı. 2025. “Investigation of the Antimicrobial Effects of Niclosamide, Furosemide and Nifedipine Drugs Released from a Modified Hydrogel Structure”. Journal of Scientific Reports-A, nos. 062: 1-11. https://doi.org/10.59313/jsr-a.1620817.

EndNote

Keskinates M, Yılmaz B, Bayrakcı M (September 1, 2025) Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure. Journal of Scientific Reports-A 062 1–11.

IEEE

[1]M. Keskinates, B. Yılmaz, and M. Bayrakcı, “Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure”, JSR-A, no. 062, pp. 1–11, Sept. 2025, doi: 10.59313/jsr-a.1620817.

ISNAD

Keskinates, Mukaddes - Yılmaz, Bahar - Bayrakcı, Mevlüt. “Investigation of the Antimicrobial Effects of Niclosamide, Furosemide and Nifedipine Drugs Released from a Modified Hydrogel Structure”. Journal of Scientific Reports-A. 062 (September 1, 2025): 1-11. https://doi.org/10.59313/jsr-a.1620817.

JAMA

1.Keskinates M, Yılmaz B, Bayrakcı M. Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure. JSR-A. 2025;:1–11.

MLA

Keskinates, Mukaddes, et al. “Investigation of the Antimicrobial Effects of Niclosamide, Furosemide and Nifedipine Drugs Released from a Modified Hydrogel Structure”. Journal of Scientific Reports-A, no. 062, Sept. 2025, pp. 1-11, doi:10.59313/jsr-a.1620817.

Vancouver

1.Mukaddes Keskinates, Bahar Yılmaz, Mevlüt Bayrakcı. Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure. JSR-A. 2025 Sep. 1;(062):1-11. doi:10.59313/jsr-a.1620817