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A DEEP TRANSFER LEARNING FRAMEWORK for the STAGING of DIABETIC RETINOPATHY

Year 2022, Issue: 051, 106 - 119, 31.12.2022

Abstract

Diabetes is a highly prevalent and increasingly common health disorder, resulting in health complications such as vision loss. Diabetic retinopathy (DR) is the most common form of diabetes-caused eye disease. Early diagnosis and treatment are crucial to prevent vision loss. DR is a progressive disease composed of five stages. The accurate diagnosis of DR stages is highly important in guiding the treatment process. In this study, we propose a deep transfer learning framework for automatic detection of DR stages. We examine our proposed model by comparing different convolutional neural networks architectures: VGGNet19, DenseNet201, and ResNet152. Our results demonstrate better accuracy after applying transfer learning and hyper-parameter tuning to classify the fundus images. When the general test accuracy and the performance evaluations are compared, the DenseNet201 model is observed with the highest test accuracy of 82.7%. Among the classification algorithms, the highest AUC value is 94.1% obtained with RestNet152.

Thanks

This research received no specific grants from any funding agency.

References

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  • [2] Lynch, S.K. and M.D. Abràmoff. (2017), Diabetic retinopathy is a neurodegenerative disorder. Vision research, 139, 101-107.
  • [3] Benson, W.E., Blodi, B.A., Boldt, H.C., Olsen, T.W., Regillo, C.D., Scott, I.U., et al. (2008), Prepared by the American Academy of Ophthalmology Retina/Vitreous Panel Members.
  • [4] Mohammadpoory, Z., Nasrolahzadeh, M., Mahmoodian N., and Haddadnia, J. (2019), Automatic identification of diabetic retinopathy stages by using fundus images and visibility graph method. Measurement, 140, 133-141.
  • [5] Biyani, R. and Patre, B. (2018), Algorithms for red lesion detection in diabetic retinopathy: a review. Biomedicine & Pharmacotherapy, 107, 681-688.
  • [6] Neffati, S., Ben Abdellafou, K., Taouali, O. and Bouzrara, K. (2020), Enhanced SVM–KPCA method for brain MR image classification. The Computer Journal, 63(3), 383-394.
  • [7] Sugeno, A., Ishikawa, Y., Ohshima, T. and Muramatsu, R. (2021), Simple methods for the lesion detection and severity grading of diabetic retinopathy by image processing and transfer learning. Computers in Biology and Medicine, 137, 104795.
  • [8] Bhardwaj, C., Jain, S. and Sood, M. (2021), Hierarchical severity grade classification of non-proliferative diabetic retinopathy. Journal of Ambient Intelligence and Humanized Computing, 12(2), 2649-2670.
  • [9] Shaban, M., Ogur, Z., Mahmoud, A., Switala, A., Shalaby, A., Abu Khalifeh, H., et al. (2020), A convolutional neural network for the screening and staging of diabetic retinopathy. Plos one, 15(6).
  • [10] De La Torre, J., Valls, A. and Puig, D. (2020), A deep learning interpretable classifier for diabetic retinopathy disease grading. Neurocomputing, 396, 465-476.
  • [11] Zhao, L., Ren, H., Zhang, J., Cao, Y., Wang, Y., Meng, D., et al. (2020), Diabetic retinopathy, classified using the lesion-aware deep learning system, predicts diabetic end-stage renal disease in Chinese patients. Endocrine Practice, 26(4), 429-443.
  • [12] Kermany, D.S., Goldbaum, M., Cai, W., Valentim, C.C., Liang, H., Baxter, S.L., et al. (2018), Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell, 172(5), 1122-1131.
  • [13] Wang, Y. and Shan, S. (2018), Accurate disease detection quantification of iris based retinal images using random implication image classifier technique. Microprocessors and Microsystems, 80, 103350.
  • [14] Wang, X., Lu, Y., Wang, Y. and Chen., W. (2018), Diabetic retinopathy stage classification using convolutional neural networks. IEEE International Conference on Information Reuse and Integration (IRI).
  • [15] Sarki, R., Michalska, S., Ahmed, K., Wang, H. and Zhang, Y. (2019), Convolutional neural networks for mild diabetic retinopathy detection: an experimental study. bioRxiv, 763136.
  • [16] Xiao, D., Yu, S., Vignarajan, J., An, D., Tay-Kearney, M.-L. and Kanagasingam, Y. (2017), Retinal hemorrhage detection by rule-based and machine learning approach. 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
  • [17] Wan, S., Liang, Y. and Zhang, Y. (2018), Deep convolutional neural networks for diabetic retinopathy detection by image classification. Computers & Electrical Engineering, 72, 274-282.
  • [18] Molina-Casado, J.M., Carmona, E.J. and García-Feijoó, J. (2017), Fast detection of the main anatomical structures in digital retinal images based on intra-and inter-structure relational knowledge. Computer methods and programs in biomedicine, 149, 55-68.
  • [19] Ur Rehman, M., Abbas, Z., Khan, S.H., and Ghani, S.H. (2018), Diabetic retinopathy fundus image classification using discrete wavelet transform. 2nd International Conference on Engineering Innovation.
  • [20] Jiang, Y., Wu, H. and Dong, J. (2017), Automatic screening of diabetic retinopathy images with convolution neural network based on caffe framework. Proceedings of the 1st International Conference on Medical and Health Informatics.
  • [21] Gao, Z., Li, J., Guo, J., Chen, Y., Yi, Z. and Zhong, J. (2018), Diagnosis of diabetic retinopathy using deep neural networks. IEEE Access, 7, 3360-3370.
  • [22] Asia Pacific Tele-Ophthalmology Society “APTOS”. (2019), Accessed april 2022. [Online]. Available: https://www.kaggle.com/c/aptos2019-blindness-detection
  • [23] Pratt, H., Coenen, F., Broadbent, D.M., Harding, S.P. and Zheng, Y. (2016), Convolutional neural networks for diabetic retinopathy. Procedia computer science, 90, 200-205.
  • [24] Deng, J., Dong, W., Socher, R., Li, L.-J., Li K. and Fei-Fei, L. (2009), Imagenet: A large-scale hierarchical image database. IEEE conference on computer vision and pattern recognition.
  • [25] LeCun, Y., Bengio, Y. and Hinton, G. (2015), Deep learning. Nature, 521, 7553, 436-444.
  • [26] He, K., Zhang, X., Ren, S. and Sun, J. (2016), Deep residual learning for image recognition. Proceedings of the IEEE conference on computer vision and pattern recognition.
  • [27] Huang, G., Liu, Z., Van Der Maaten, L. and Weinberger, K.Q. (2017), Densely connected convolutional networks. Proceedings of the IEEE conference on computer vision and pattern recognition.
  • [28] Simonyan, K. and Zisserman, A. (2014), Very deep convolutional networks for large-scale image recognition. arXiv preprint, 1409-1556.
  • [29] Patil, S.B. and Patil, B. (2020), Retinal fundus image enhancement using adaptive CLAHE methods. Journal of Seybold Report, (1533), 9211.
  • [30] Khalifa, N.E.M., Loey, M., Taha, M.H.N. and Mohamed., H.N.E.T. (2019), Deep transfer learning models for medical diabetic retinopathy detection. Acta Informatica Medica, 27(5), 327.
  • [31] Lam, C. , Yi, D., Guo, M. and Lindsey, T. (2018), Automated detection of diabetic retinopathy using deep learning, AMIA summits on translational science proceedings, 147.
  • [32] Kumar, G., Chatterjee, S.K. and Chattopadhyay, C. (2020), Drdnet: Diagnosis of diabetic retinopathy using capsule network (Workshop Paper), IEEE Sixth International Conference on Multimedia Big Data (BigMM), 379-385.
  • [33] Lahmar, C., and Ali, I. (2022), Deep hybrid architectures for diabetic retinopathy classification. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 1-19.
  • [34] Anoop, B.K. (2022), Binary classification of DR-diabetic retinopathy using CNN with fundus colour images. Materials Today: Proceedings 58, 212-216.
  • [35] Mungloo-Dilmohamud, Z., Heenaye-Mamode Khan, M., Jhumka, K., Beedassy, B.N., Mungloo, N.Z. and Peña-Reyes, C. (2022), Balancing data through data augmentation improves the generality of transfer learning for diabetic retinopathy classification. Applied Sciences 12(11), 5363.
Year 2022, Issue: 051, 106 - 119, 31.12.2022

Abstract

References

  • [1] Roglic, G. (2016), WHO global report on diabetes: a summary. International Journal of Noncommunicable Diseases, 1(1), 3.
  • [2] Lynch, S.K. and M.D. Abràmoff. (2017), Diabetic retinopathy is a neurodegenerative disorder. Vision research, 139, 101-107.
  • [3] Benson, W.E., Blodi, B.A., Boldt, H.C., Olsen, T.W., Regillo, C.D., Scott, I.U., et al. (2008), Prepared by the American Academy of Ophthalmology Retina/Vitreous Panel Members.
  • [4] Mohammadpoory, Z., Nasrolahzadeh, M., Mahmoodian N., and Haddadnia, J. (2019), Automatic identification of diabetic retinopathy stages by using fundus images and visibility graph method. Measurement, 140, 133-141.
  • [5] Biyani, R. and Patre, B. (2018), Algorithms for red lesion detection in diabetic retinopathy: a review. Biomedicine & Pharmacotherapy, 107, 681-688.
  • [6] Neffati, S., Ben Abdellafou, K., Taouali, O. and Bouzrara, K. (2020), Enhanced SVM–KPCA method for brain MR image classification. The Computer Journal, 63(3), 383-394.
  • [7] Sugeno, A., Ishikawa, Y., Ohshima, T. and Muramatsu, R. (2021), Simple methods for the lesion detection and severity grading of diabetic retinopathy by image processing and transfer learning. Computers in Biology and Medicine, 137, 104795.
  • [8] Bhardwaj, C., Jain, S. and Sood, M. (2021), Hierarchical severity grade classification of non-proliferative diabetic retinopathy. Journal of Ambient Intelligence and Humanized Computing, 12(2), 2649-2670.
  • [9] Shaban, M., Ogur, Z., Mahmoud, A., Switala, A., Shalaby, A., Abu Khalifeh, H., et al. (2020), A convolutional neural network for the screening and staging of diabetic retinopathy. Plos one, 15(6).
  • [10] De La Torre, J., Valls, A. and Puig, D. (2020), A deep learning interpretable classifier for diabetic retinopathy disease grading. Neurocomputing, 396, 465-476.
  • [11] Zhao, L., Ren, H., Zhang, J., Cao, Y., Wang, Y., Meng, D., et al. (2020), Diabetic retinopathy, classified using the lesion-aware deep learning system, predicts diabetic end-stage renal disease in Chinese patients. Endocrine Practice, 26(4), 429-443.
  • [12] Kermany, D.S., Goldbaum, M., Cai, W., Valentim, C.C., Liang, H., Baxter, S.L., et al. (2018), Identifying medical diagnoses and treatable diseases by image-based deep learning. Cell, 172(5), 1122-1131.
  • [13] Wang, Y. and Shan, S. (2018), Accurate disease detection quantification of iris based retinal images using random implication image classifier technique. Microprocessors and Microsystems, 80, 103350.
  • [14] Wang, X., Lu, Y., Wang, Y. and Chen., W. (2018), Diabetic retinopathy stage classification using convolutional neural networks. IEEE International Conference on Information Reuse and Integration (IRI).
  • [15] Sarki, R., Michalska, S., Ahmed, K., Wang, H. and Zhang, Y. (2019), Convolutional neural networks for mild diabetic retinopathy detection: an experimental study. bioRxiv, 763136.
  • [16] Xiao, D., Yu, S., Vignarajan, J., An, D., Tay-Kearney, M.-L. and Kanagasingam, Y. (2017), Retinal hemorrhage detection by rule-based and machine learning approach. 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).
  • [17] Wan, S., Liang, Y. and Zhang, Y. (2018), Deep convolutional neural networks for diabetic retinopathy detection by image classification. Computers & Electrical Engineering, 72, 274-282.
  • [18] Molina-Casado, J.M., Carmona, E.J. and García-Feijoó, J. (2017), Fast detection of the main anatomical structures in digital retinal images based on intra-and inter-structure relational knowledge. Computer methods and programs in biomedicine, 149, 55-68.
  • [19] Ur Rehman, M., Abbas, Z., Khan, S.H., and Ghani, S.H. (2018), Diabetic retinopathy fundus image classification using discrete wavelet transform. 2nd International Conference on Engineering Innovation.
  • [20] Jiang, Y., Wu, H. and Dong, J. (2017), Automatic screening of diabetic retinopathy images with convolution neural network based on caffe framework. Proceedings of the 1st International Conference on Medical and Health Informatics.
  • [21] Gao, Z., Li, J., Guo, J., Chen, Y., Yi, Z. and Zhong, J. (2018), Diagnosis of diabetic retinopathy using deep neural networks. IEEE Access, 7, 3360-3370.
  • [22] Asia Pacific Tele-Ophthalmology Society “APTOS”. (2019), Accessed april 2022. [Online]. Available: https://www.kaggle.com/c/aptos2019-blindness-detection
  • [23] Pratt, H., Coenen, F., Broadbent, D.M., Harding, S.P. and Zheng, Y. (2016), Convolutional neural networks for diabetic retinopathy. Procedia computer science, 90, 200-205.
  • [24] Deng, J., Dong, W., Socher, R., Li, L.-J., Li K. and Fei-Fei, L. (2009), Imagenet: A large-scale hierarchical image database. IEEE conference on computer vision and pattern recognition.
  • [25] LeCun, Y., Bengio, Y. and Hinton, G. (2015), Deep learning. Nature, 521, 7553, 436-444.
  • [26] He, K., Zhang, X., Ren, S. and Sun, J. (2016), Deep residual learning for image recognition. Proceedings of the IEEE conference on computer vision and pattern recognition.
  • [27] Huang, G., Liu, Z., Van Der Maaten, L. and Weinberger, K.Q. (2017), Densely connected convolutional networks. Proceedings of the IEEE conference on computer vision and pattern recognition.
  • [28] Simonyan, K. and Zisserman, A. (2014), Very deep convolutional networks for large-scale image recognition. arXiv preprint, 1409-1556.
  • [29] Patil, S.B. and Patil, B. (2020), Retinal fundus image enhancement using adaptive CLAHE methods. Journal of Seybold Report, (1533), 9211.
  • [30] Khalifa, N.E.M., Loey, M., Taha, M.H.N. and Mohamed., H.N.E.T. (2019), Deep transfer learning models for medical diabetic retinopathy detection. Acta Informatica Medica, 27(5), 327.
  • [31] Lam, C. , Yi, D., Guo, M. and Lindsey, T. (2018), Automated detection of diabetic retinopathy using deep learning, AMIA summits on translational science proceedings, 147.
  • [32] Kumar, G., Chatterjee, S.K. and Chattopadhyay, C. (2020), Drdnet: Diagnosis of diabetic retinopathy using capsule network (Workshop Paper), IEEE Sixth International Conference on Multimedia Big Data (BigMM), 379-385.
  • [33] Lahmar, C., and Ali, I. (2022), Deep hybrid architectures for diabetic retinopathy classification. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 1-19.
  • [34] Anoop, B.K. (2022), Binary classification of DR-diabetic retinopathy using CNN with fundus colour images. Materials Today: Proceedings 58, 212-216.
  • [35] Mungloo-Dilmohamud, Z., Heenaye-Mamode Khan, M., Jhumka, K., Beedassy, B.N., Mungloo, N.Z. and Peña-Reyes, C. (2022), Balancing data through data augmentation improves the generality of transfer learning for diabetic retinopathy classification. Applied Sciences 12(11), 5363.
There are 35 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Research Articles
Authors

Gökalp Çınarer 0000-0003-0818-6746

Kazım Kılıç 0000-0003-2168-1338

Tuba Parlar 0000-0002-8004-6150

Publication Date December 31, 2022
Submission Date August 25, 2022
Published in Issue Year 2022 Issue: 051

Cite

IEEE G. Çınarer, K. Kılıç, and T. Parlar, “A DEEP TRANSFER LEARNING FRAMEWORK for the STAGING of DIABETIC RETINOPATHY”, JSR-A, no. 051, pp. 106–119, December 2022.