Case Report
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Year 2025, Volume: 5 Issue: 1, 10 - 14, 30.06.2025
https://doi.org/10.5281/zenodo.15755450

Abstract

References

  • Soltero-Rivera M, Goldschmidt S, Arzi B. Feline chronic gingivostomatitis current concepts in clinical management. J Feline Med Surg. 2023;25(8):1098612X231186834.
  • Older CE, Gomes MDOS, Hoffmann AR, et al. Influence of the FIV status and chronic gingivitis on feline oral microbiota. Pathogens. 2020;9(5):383.
  • Belgard S, Truyen U, Thibault JC, Sauter-Louis C, Hartmann K. Relevance of feline calicivirus, feline immunodeficiency virus, feline leukemia virus, feline herpesvirus and Bartonella henselae in cats with chronic gingivostomatitis. Berl Munch Tierarztl Wochenschr. 2010;123(9-10):369-376.
  • Ahmad AM, Ali OJ, Marif HF, Ali BA. Therapeutic Management of Chronic Gingivostomatitis In Cats. A Comprehensive Review. Basrah J Vet Res. 2024;23(3):156-169.
  • Bellei E, Dalla F, Masetti L, Pisoni L, Joechler M. Surgical therapy in chronic feline gingivostomatitis (FCGS). Vet Res Commun. 2008;32:231-234.
  • Szondi DC, Wong JK, Vardy LA, Cruickshank SM. Arginase signalling as a key player in chronic wound pathophysiology and healing. Front Mol Biosci. 2021;8:773866.
  • Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856.
  • Druet I, Hennet P. Relationship between feline calicivirus load, oral lesions, and outcome in feline chronic gingivostomatitis (caudal stomatitis): retrospective study in 104 cats. Front Vet Sci. 2017;4:209.
  • Matsumoto H, Teshima T, Iizuka Y, Sakusabe A, Takahashi D, Amimoto A, Koyama H. Evaluation of the efficacy of the subcutaneous low recombinant feline interferon-omega administration protocol for feline chronic gingivitis-stomatitis in feline calicivirus-positive cats. Res Vet Sci. 2018;121:53-58.
  • 1Johnston, N. (2012). An updated approach to chronic feline gingivitis stomatitis syndrome. Veterinary Practice, 44, 34-38.
  • 1Mamo JC, Naissides M. Could iodine be effective in the treatment of human immunodeficiency virus and AIDS-associated opportunistic infections? Int J Infect Dis. 2005;9(5):292-293.
  • 1Bingen A, Nonnenmacher H, Bastien-Valle M, Martin JP. Tissues rich in macrophagic cells are the major sites of feline immunodeficiency virus uptake after intravenous inoculation into cats. Microbes Infect. 2002;4(8):795-803.
  • 1Vahlenkamp TW, Tompkins MB, Tompkins WA. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+ CD25+ T regulatory cells. J Immunol. 2004;172(8):4752-4761.
  • Cloke TE, Garvey L, Choi BS, et al. Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis. 2010;202(3):374-385.
  • Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856.

Innovative Nutraceutical Approach in the Treatment of Chronic Gingivostomatitis: Insights Gained from the Case

Year 2025, Volume: 5 Issue: 1, 10 - 14, 30.06.2025
https://doi.org/10.5281/zenodo.15755450

Abstract

A nine-year-old female domestic shorthair cat presented with lethargy, anorexia, recurrent severe oral lesions, and oral pain. The cat was diagnosed with FCGS associated with FIV infection. Management was followed with a nutraceutical supplement including primarily iodine and arginine. Over a 2.5-month period, significant clinical improvements were observed, including resolution of oral lesions, increased appetite, and improved activity levels. This case report highlighted the potential role of nutraceuticals as a treatment regime for managing FCGS in FIV-positive cats, particularly in cases resistant to traditional treatments.

Thanks

This case report abstract was presented at the 1st International Veterinary Internal Medicine Symposium titled "Nutritional Disorders and Cardiology in Cats and Dogs.

References

  • Soltero-Rivera M, Goldschmidt S, Arzi B. Feline chronic gingivostomatitis current concepts in clinical management. J Feline Med Surg. 2023;25(8):1098612X231186834.
  • Older CE, Gomes MDOS, Hoffmann AR, et al. Influence of the FIV status and chronic gingivitis on feline oral microbiota. Pathogens. 2020;9(5):383.
  • Belgard S, Truyen U, Thibault JC, Sauter-Louis C, Hartmann K. Relevance of feline calicivirus, feline immunodeficiency virus, feline leukemia virus, feline herpesvirus and Bartonella henselae in cats with chronic gingivostomatitis. Berl Munch Tierarztl Wochenschr. 2010;123(9-10):369-376.
  • Ahmad AM, Ali OJ, Marif HF, Ali BA. Therapeutic Management of Chronic Gingivostomatitis In Cats. A Comprehensive Review. Basrah J Vet Res. 2024;23(3):156-169.
  • Bellei E, Dalla F, Masetti L, Pisoni L, Joechler M. Surgical therapy in chronic feline gingivostomatitis (FCGS). Vet Res Commun. 2008;32:231-234.
  • Szondi DC, Wong JK, Vardy LA, Cruickshank SM. Arginase signalling as a key player in chronic wound pathophysiology and healing. Front Mol Biosci. 2021;8:773866.
  • Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856.
  • Druet I, Hennet P. Relationship between feline calicivirus load, oral lesions, and outcome in feline chronic gingivostomatitis (caudal stomatitis): retrospective study in 104 cats. Front Vet Sci. 2017;4:209.
  • Matsumoto H, Teshima T, Iizuka Y, Sakusabe A, Takahashi D, Amimoto A, Koyama H. Evaluation of the efficacy of the subcutaneous low recombinant feline interferon-omega administration protocol for feline chronic gingivitis-stomatitis in feline calicivirus-positive cats. Res Vet Sci. 2018;121:53-58.
  • 1Johnston, N. (2012). An updated approach to chronic feline gingivitis stomatitis syndrome. Veterinary Practice, 44, 34-38.
  • 1Mamo JC, Naissides M. Could iodine be effective in the treatment of human immunodeficiency virus and AIDS-associated opportunistic infections? Int J Infect Dis. 2005;9(5):292-293.
  • 1Bingen A, Nonnenmacher H, Bastien-Valle M, Martin JP. Tissues rich in macrophagic cells are the major sites of feline immunodeficiency virus uptake after intravenous inoculation into cats. Microbes Infect. 2002;4(8):795-803.
  • 1Vahlenkamp TW, Tompkins MB, Tompkins WA. Feline immunodeficiency virus infection phenotypically and functionally activates immunosuppressive CD4+ CD25+ T regulatory cells. J Immunol. 2004;172(8):4752-4761.
  • Cloke TE, Garvey L, Choi BS, et al. Increased level of arginase activity correlates with disease severity in HIV-seropositive patients. J Infect Dis. 2010;202(3):374-385.
  • Paßlack N, Kohn B, Zentek J. Effects of arginine and ornithine supplementation to a high-protein diet on selected cellular immune variables in adult cats. J Vet Intern Med. 2020;34(2):852-856.
There are 15 citations in total.

Details

Primary Language English
Subjects Veterinary Internal Medicine
Journal Section Case Reports
Authors

Songül Erdoğan 0000-0002-7833-5519

Tahir Özalp

Hasan Erdoğan

Kerem Ural

Publication Date June 30, 2025
Submission Date December 12, 2024
Acceptance Date March 3, 2025
Published in Issue Year 2025 Volume: 5 Issue: 1

Cite

AMA Erdoğan S, Özalp T, Erdoğan H, Ural K. Innovative Nutraceutical Approach in the Treatment of Chronic Gingivostomatitis: Insights Gained from the Case. J Vet Case Rep. June 2025;5(1):10-14. doi:10.5281/zenodo.15755450

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