Assessment of the Relationship Between Serum Albumin to Creatinine Ratio and Long-Term Mortality in Patients with ST-Segment Elevation Myocardial Infarction

Abstract

Aim: In recent years, an increasing number of evidence suggests that the inflammation plays a significant role in the pathophysiology of ST-segment elevation myocardial infarction (STEMI). The association between inflammatory markers and renal functions in STEMI prognosis has been previously reported. No studies have investigated the ability of the serum albumin to creatinine ratio (sACR), defined as a prognostic score, to predict long term mortality in patients experiencing STEMI. Material and Method: This retrospective study included 1133 patients experiencing STEMI. The study population was divided into two groups according to survival and analyzed whether the sACR was an independent predictor of long-term mortality. Results: Out of 1133 patients, death was observed in 112 patients (9%) an average follow-up of 55 months. During the total follow-up period, patients were divided into two groups according to survival. Compared to the survival group, long-term mortality group was older, had a higher SYNTAX score and a lower sACR (p<0.05). Independent predictors of long-term mortality were found to be age, smoking, LVEF, and sACR (HR: 0.627 95% CI: 0.533–0.737; p<0.001). Receiver operating characteristic (ROC) curve comparisons for long-term mortality demonstrated that the sACR was a better predictor than both albumin and creatinine, separately. Conclusion: The present study revealed that sACR is an independent predictor of long-term mortality in patients experiencing STEMI. As a marker which can be easily obtained and calculated, sACR can be an effective parameter used for prognosis estimation of STEMI.

Keywords

• serum albumin
• creatinine
• sACR; mortality
• ST-segment elevation myocardial infarction

References

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