Short-Term Effect of Prostaglandin Group Antiglaucomatous Drugs on Choroid Thickness

Abstract

Aim: To evaluate the effects of patients with whom we started prostaglandin analogues for primary open-angle glaucoma (POAG) by measuring the choroidal thickness with Enhanced-Depth Imaging - Optical Coherence Tomography (EDI-OCT). Material and Method: Thirty-two eyes of 32 patients (Group 1) in whom prostaglandin analogues antiglaucomatous drops were initiated, 32 eyes of 32 patients (Group 2) who were initiated with different groups of antiglaucomatous drugs, and 32 eyes of 32 healthy individuals (control group) were included in the study. Before the drug, these groups’ submacular choroidal thickness (CT) and intraocular pressure (IOP) were measured with EDI-OCT. Submacular CT of the same groups was measured in the 1st week, the 1st month, and the 3rd month after starting the drug.. Results: A significant increase was detected in mean submacular CT thickness measurements with drug use in both Group 1 and Group 2 (p<0.001). Although the choroidal thickness was thinner in pre-treatment glaucoma groups, there was no significant difference in CT (p=0.072). There was no statistically significant difference between the mean Submacular CT groups of all groups at three months (p=0.198). The decrease in IOP in the glaucoma groups was statistically significant (p<0.001, p<0.001, respectively). Conclusion: A significant increase in submacular CT values was detected in patients who started prostaglandin or non-prostaglandin antiglaucomatous due to POAG. In addition, no statistically significant difference was found between the glaucoma groups regarding choroidal change.

Keywords

• choroidal thickness
• optical coherence tomography
• prostaglandin analogues
• intraocular pressure

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