Management Strategies for Synchronous Primary Lung Tumors: A Retrospective Two-Centre Study

Abstract

Aim: Synchronous primary lung tumors are uncommon and diverse clinical entities. Distinguishing them from intrapulmonary metastases is essential for accurate staging, prognosis evaluation, and selecting the right treatment. This study seeks to describe the clinical, radiological, and histopathological features of synchronous primary lung tumors and to aid in the diagnostic and treatment decision-making process. Material and Methods: Between January 2023 and January 2025, patients diagnosed with synchronous primary lung tumors and evaluated at two tertiary centers were retrospectively analyzed. Clinical, radiological, and histopathological data were reviewed, including smoking history, occupational or environmental exposures, and TNM staging. Treatment strategies and follow-up outcomes were recorded. Results: Out of 250 patients undergoing diagnostic or therapeutic interventions for lung cancer during the study period, four patients (1.6%) met the criteria for synchronous primary lung tumors. Detailed case-based analyses highlighted the heterogeneity in histologic subtypes, anatomical locations, and treatment approaches. Conclusion: Synchronous primary lung tumors are rare but clinically significant. Comprehensive clinical evaluation, detailed histopathologic assessment, and individualized management strategies are essential to optimize outcomes.

Keywords

• Synchronous lung tumors
• multiple primary lung cancers
• surgical management
• personalized therapy
• thoracic oncology.

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