Can Laboratory Parameters Predict Intensive Care Unit Admission in COVID-19? A Focus on Magnesium Levels

Abstract

Aim: COVID-19 has emerged as a disease that poses a significant global health problem. It can be seen from asymptomatic to intensive care and death. Magnesium is the main cation in the human body. The prognostic role of magnesium, which also plays a role in inflammation as an enzymatic activator, is not clear. Our aim is to investigate whether magnesium is a factor that predicts admission to the intensive care unit (ICU). Materials and Methods: This retrospective study recorded the magnesium values and discharge-intensive care status of patients hospitalized in the chest diseases clinic. Results: 426 patients were included in the study. The mean age of the participants was 64.4±14.5 years, and the mean magnesium value was 2.1±0.3 mg/dl. Patients who were discharged from the hospital and those who went to the ICU had similar magnesium values. Conclusion: Although there is still no clarity on the clinical effects of magnesium, various relationships between magnesium levels and COVID-19 have been shown. However, no relationship was found between magnesium levels and intensive care unit admission.

Keywords

• magnesium
• COVID-19
• intensive care unit

References

1. 1. Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574–81.
2. 2. Guan W-j, Ni Z-y, Hu Y, Liang W-h, Ou C-q, He J-x, et al. Clinical characteristics of coronavirus disease 2019 in China. New England Journal of Medicine. 2020;382(18):1708–20.
3. 3. Tang C-F, Ding H, Jiao R-Q, Wu X-X, Kong L-D. Possibility of magnesium supplementation for supportive treatment in patients with COVID-19. European Journal of Pharmacology. 2020;886:173546.
4. 4. Palmer BF, Clegg DJ. Physiology and pathophysiology of potassium homeostasis. Advances in Physiology Education. 2016;40(4):480–90.
5. 5. Komiya Y, Runnels LW. TRPM channels and magnesium in early embryonic development. The International Journal of Developmental Biology. 2015;59:281.
6. 6. Ohyama T. New aspects of magnesium function: a key regulator in nucleosome self-assembly, chromatin folding and phase separation. International Journal of Molecular Sciences. 2019;20(17):4232.
7. 7. Guerrero-Romero F, Micke O, Simental-Mendía LE, RodríguezMorán M, Vormann J, Iotti S, et al. Importance of magnesium status in COVID-19. Biology. 2023;12(5):735.
8. 8. Jia L, Wei Z, Zhang H, Wang J, Jia R, Zhou M, et al. An interpretable machine learning model based on a quick prescreening system enables accurate deterioration risk prediction for COVID-19. Scientific Reports. 2021;11(1):23127.

9. 9. da Silva Lima F, da Rocha Romero AB, Hastreiter A, Nogueira-Pedro A, Makiyama E, Colli C, et al. An insight into the role of magnesium in the immunomodulatory properties of mesenchymal stem cells. T he Journal of Nutritional Biochemistry. 2018;55:200–8.
10. 10. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. The Lancet Respiratory Medicine. 2020;8(12):1233–44.
11. 11. Oskay A, Çakmak V, Şenol H, Oskay T, Özen M, Yılmaz A, et al. Association of Admission Troponin Levels with Hospitalization and Mortality in COVID-19 Patients. Kafkas Journal of Medical Sciences. 2022;12(2):152–9.
12. 12. Quilliot D, Bonsack O, Jaussaud R, Mazur A. Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors. Magnesium Research. 2020;33(4):114–22.
13. 13. Guerrero-Romero F, Mercado M, Rodriguez-Moran M, Ramírez-Renteria C, Martínez-Aguilar G, Marrero-Rodríguez D, et al. Magnesium-to-calcium ratio and mortality from COVID-19. Nutrients. 2022;14(9):1686.
14. 14. Beigmohammadi MT, Bitarafan S, Abdollahi A, Amoozadeh L, Salahshour F, Soltani D, et al. The association between serum levels of micronutrients and the severity of disease in patients with COVID-19. Nutrition. 2021;91:111400.
15. 15. Mohamed AO. Hyper-and hypomagnesemia as an initial predictor of outcomes in septic pediatric patients in Egypt. Acute and Critical Care. 2025;40(1):105.
16. 16. Patil PS, Aslam S. Study of serum magnesium levels in patients admitted with sepsis in intensive care unit. Kathmandu Univ Med J (KUMJ). 2023;21(81):23–7.
17. 17. Sharma R, Heidari A, Johnson RH, Advani S, Petersen G. Serum magnesium levels in hospitalized patients with SARSCoV-2. Journal of Investigative Medicine. 2022;70(2):40914