Placental Expression of KISS1 and KISS1R in Unexplained Recurrent Pregnancy Loss

Year 2025, Volume: 15 Issue: 3, 371 - 377, 05.01.2026

Gülnur Çoban , Adem Kocaman , Enes Furkan Çoban , Mesut Önal , Ayşe Zehra Özdemir , Bülent Ayas , İdris Koçak

Abstract

Aim: Thrombosis of the placental bed has been postulated to be partly responsible for placenta-related pregnancy complications. There are studies showing that patients with abortion have placental invasion disorder rather than thrombosis. The aim of this study was to examine the expression levels of kisspeptin, which has attracted attention in recent years with its effects on implantation, placental proliferation and apoptosis, in placentas belonging to pregnancy, where women with an unexplained recurrent pregnancy loss history reached term and gave healthy birth.
Patients and Methods: The study included 20 placenta samples belonging to women with a history of recurrent pregnancy loss and reached the term pregnancy in the experimental group, 20 placenta samples belonging to women with a history of recurrent pregnancy loss and reached the term by receiving low molecular weight heparin treatment throughout their pregnancy in the drug+experiment group, and 20 placenta samples belonging to healthy women without a history of recurrent pregnancy loss and reached the term in the control group. Collected tissues were analyzed immunohistochemically following routine histological procedures.
Results: Kisspeptin expression level was significantly higher in the control group, while it was at the lowest level in the experimental group, and it was relatively increased in the drug+experiment group. There was no statistically significant difference between the groups in terms of kisspeptin receptor expression levels.
Conclusion: Abnormal kisspeptin expression levels may be associated with obstetric complications. Even if a pregnancy resulting in a live birth is achieved in women with a history of recurrent pregnancy loss, differences in kisspeptin expression levels seem to persist compared to women with similar characteristics who do not have a bad obstetric history.

Keywords

recurrent pregnancy loss , placenta-related pregnancy complications , livebirth , Kisspeptin

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