The Relationship Between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Microvascular Complications in Patients with Type 2 Diabetes Mellitus

Abstract

Aim: This study investigates the relationship between the monocyte- to-high-density lipoprotein cholesterol ratio (MHR) and microvascular complications (nephropathy, retinopathy, and neuropathy) in patients with type 2 diabetes mellitus (T2DM). With the increasing global burden of diabetes and its associated complications, identifying simple and accessible biomarkers for early prediction and management is of great importance. Materials and Methods: The data of 229 T2DM patients who applied to the internal medicine and diabetes outpatient clinics of Haseki Training and Research Hospital between June 1, 2012, and June 1, 2017, were retrospectively analyzed. Demographic, clinical, and laboratory data, including MHR values, were collected. Statistical analyses were performed using IBM Statistical Package for Social Sciences (SPSS) program version 23.0, and a significance level of p<0.05 was considered. The Mann-Whitney U test was used for data that did not show a normal distribution. Results: Of the 229 patients included in the study, 52.8% were female, and the mean age was 56.7 years. Diabetic retinopathy (DRP) was detected in 28.8% of the patients, diabetic nephropathy (DN) in 34.5%, and diabetic neuropathy in 42.8%. A statistically significant relationship was found between MHR and DRP (p=0.015) and between MHR and DN (p<0.001); however, no significant association was found between MHR and neuropathy (p=0.124). Conclusion: Monocyte-to-high-density lipoprotein cholesterol ratio may be a useful and easily calculable marker for predicting diabetic retinopathy and nephropathy in patients with type 2 diabetes. However, no significant relationship was found between MHR and diabetic neuropathy. Further prospective studies are needed to confirm the prognostic value of MHR in clinical practice. Key words: monocyte-to-HDL cholesterol ratio; type 2 diabetes mellitus; microvascular complications; diabetic nephropathy; diabetic retinopathy; diabetic neuropathy

Keywords

• Monocyte-to-HDL cholesterol ratio
• type 2 diabetes mellitus
• microvascular complications
• diabetic nephropathy
• diabetic retinopathy
• diabetic neuropathy

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