Investigation of the Relationship Between Serum Copper, Zinc, and Magnesium Levels and Benign Paroxysmal Positional Vertigo (BPPV)

Year 2026, Volume: 16 Issue: 1, 74 - 80, 19.03.2026

Ömer Faruk Demir , Abdulsamed Kükürt

https://izlik.org/JA44AY54GW

Abstract

Aim: This study examined the association between serum trace element
concentrations (copper, magnesium, and zinc) and benign
paroxysmal positional vertigo (BPPV), a common cause of vertigo.
Materials and Methods: This retrospective study was conducted
by reviewing laboratory data recorded in the hospital automation
system for patients who presented with vertigo at the Kafkas
University Health Practice and Research Center between January
1, 2022, and April 1, 2024. A total of 119 individuals were included,
comprising 81 (68.07%) patients diagnosed with BPPV and
38 (31.93%) in the control group. Participants had a mean age of
52 years; females accounted for 60.5% of the cohort, while males
comprised 39.5%.
Results: Comparative analyses revealed distinct serum copper,
magnesium, and zinc profiles between the BPPV and control
groups (p<0.05). Higher copper and magnesium concentrations
were observed in individuals with BPPV, whereas zinc levels were
greater in the control group. Among the trace elements examined,
magnesium demonstrated the strongest association with BPPV,
with higher levels corresponding to a 9,709-fold increase in the
odds of the disorder.
Conclusion: Alterations in serum trace element levels, particularly
increased magnesium levels, may be related to the presence of
BPPV. These findings suggest that mineral metabolism may play a
contributory role in vestibular disorders and provide a foundation
for further research in this field.

Keywords

Vertigo , Magnesium , Copper , Zinc

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