Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen

Doğan Koca; Davut Demir; Oğuzhan Özdemir; Hüseyin Akdeniz; Mehmet Kurt

TR EN

Oksaliplatin-Temelli Rejim Altında Progresyon Gösteren Metastatik Kolorektal Kanserli Hastalarda Modifiye Folfiri-Bevasizumab Rejimi

Abstract

İlk-sıra tedavide oksaliplatin-temelli rejim alan metastatik kolorektal kanserli (mKRK) hastalarda ikinci-sıra tedavide modifiye FOLFIRI-Bevacizumab (mFOLFIRI-B) rejiminin etkinlik ve tolerabilitesi araştırıldı. Materyal ve Metot: Çalışmaya ilk-sıra tedavide oksaliplatin-temelli rejim alan, ardından progresyon gözlenen ve ikinci-sıra tedavide mFOLFIRI-B rejimi alan mKRK’li hastalar alındı. Toksisite ve etkinlik ile ilgili veriler retrospektif olarak değerlendirildi.Bulgular: Toplam 172 mKRK’li hasta ikinci-sıra tedavide mFOLFIRI-B rejimi almıştı. Hastaların %39,5’inde objektif cevap, 9,0 aylık (7,6 ile 10,3 arası) median progresyonsuz yaşam, 19,0 aylık (15,1 ile 26,2 arası) median tüm yaşam saptandı. Grade 3/4 toksisite %33,7 oranında tespit edildi. Grade 3/4 hematolojik toksisite %31,9 oranında tespit edildi. Sonuç: Sonuç olarak mKRK’li hastalarda oksaliplatin-temelli rejim sonrası ikinci-sıra tedavide mFOLFIRI-B rejimi etkili ve güvenilir bir tedavi rejimidir.

Keywords

metastatik kolorektal kanser, ikinci-sıra kemoterapi rejimi, modifiye FOLFIRI-Bevacizumab rejimi

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Doğan Koca This is me

Davut Demir This is me

Oğuzhan Özdemir This is me

Hüseyin Akdeniz This is me

Mehmet Kurt This is me

Publication Date

March 1, 2017

Submission Date

March 1, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 7 Number: 1

IZ

https://izlik.org/JA72LG96AA

Cite

RIS / Bibtex

APA

Koca, D., Demir, D., Özdemir, O., Akdeniz, H., & Kurt, M. (2017). Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen. Kafkas Journal of Medical Sciences, 7(1), 53-59. https://izlik.org/JA72LG96AA

AMA

1.Koca D, Demir D, Özdemir O, Akdeniz H, Kurt M. Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen. Kafkas Journal of Medical Sciences. 2017;7(1):53-59. https://izlik.org/JA72LG96AA

Chicago

Koca, Doğan, Davut Demir, Oğuzhan Özdemir, Hüseyin Akdeniz, and Mehmet Kurt. 2017. “Modified FOLFIRI-Bevacizumab Regimen in the Patients With Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen”. Kafkas Journal of Medical Sciences 7 (1): 53-59. https://izlik.org/JA72LG96AA.

EndNote

Koca D, Demir D, Özdemir O, Akdeniz H, Kurt M (April 1, 2017) Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen. Kafkas Journal of Medical Sciences 7 1 53–59.

IEEE

[1]D. Koca, D. Demir, O. Özdemir, H. Akdeniz, and M. Kurt, “Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen”, Kafkas Journal of Medical Sciences, vol. 7, no. 1, pp. 53–59, Apr. 2017, [Online]. Available: https://izlik.org/JA72LG96AA

ISNAD

Koca, Doğan - Demir, Davut - Özdemir, Oğuzhan - Akdeniz, Hüseyin - Kurt, Mehmet. “Modified FOLFIRI-Bevacizumab Regimen in the Patients With Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen”. Kafkas Journal of Medical Sciences 7/1 (April 1, 2017): 53-59. https://izlik.org/JA72LG96AA.

JAMA

1.Koca D, Demir D, Özdemir O, Akdeniz H, Kurt M. Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen. Kafkas Journal of Medical Sciences. 2017;7:53–59.

MLA

Koca, Doğan, et al. “Modified FOLFIRI-Bevacizumab Regimen in the Patients With Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen”. Kafkas Journal of Medical Sciences, vol. 7, no. 1, Apr. 2017, pp. 53-59, https://izlik.org/JA72LG96AA.

Vancouver

1.Doğan Koca, Davut Demir, Oğuzhan Özdemir, Hüseyin Akdeniz, Mehmet Kurt. Modified FOLFIRI-Bevacizumab Regimen in the Patients with Metastatic Colorectal Cancer Who Had Progressed After Oxaliplatin-Based Regimen. Kafkas Journal of Medical Sciences [Internet]. 2017 Apr. 1;7(1):53-9. Available from: https://izlik.org/JA72LG96AA