Incretin Based Therapies in Type 2 Diabetes Mellitus

Year 2017, , 174 - 180, 01.08.2017

Uğur Alp Göksu , Aysun Ünal

https://doi.org/10.5505/kjms.2017.94830

Abstract

For the treatment of T2DM; cure can not be achieved with conventional
methods. The degree of increase in the epidemic of diabetes;
together with the research of new treatments will provide a
better understanding of patophysiology necessitates the development.
Preferred drugs in cases that do not respond to metformin;
hypoglycemia, can cause weight gain and are undesirable cardiac
event. Today; incretin-based therapies have been developed that
provide effective glucose level and weight control. Incretins while
increasing glucose dependent insulin secretion in the pancreas,
suppress glucagon secretion.
Glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4
inhibitors, are incretin based treatment. Glucagon-like
peptide-1 receptor agonists is the most important treatment can
be used with monotherapy or combination therapy. Glucagon-like
peptide-1 agonists, besides providing good glycemic control, the
low rate of hypoglycemia and weight loss are causing significant
advantage. Dipeptidyl peptidase-4 inhibitors; leads to rapid inactivation
of incretin hormones such as glucagon-like peptide-1
agonists and glucose dependent insulinotropic polypeptide.
Dipeptidyl peptidase-4 inhibitors; they extend the duration of action
of glucagon-like peptide-1 by inhibiting the degradation of incretin
hormones in circulation

Keywords

incretine; glucagone like peptide-1; dipeptidyl peptidase-4 inhibitors

Diabetes Mellitus Tip 2’de İnkretin Temelli Tedaviler

Abstract

Diyabet tedavisinde, geleneksel yöntemlerle kür sağlanamamaktadır.
Diyabetin salgın derecesinde artışı patofizyolojsinin daha iyi
anlaşılmasını sağlayacak araştırmalarla birlikte yeni tedavilerin geliştirilmesini
zorunlu kılmaktadır. Metformin tedavisine cevap vermeyen
durumlarda tercih edilen ilaçlar; hipoglisemi, kilo alımı ve
istenmeyen kardiak olaylara neden olabilmektedirler. Günümüzde
etkin glukoz ve kilo kontrolü sağlayan inkretin bazlı tedaviler geliştirilmiştir.
İnkretinler pankreasta glukoza bağımlı insülin sekresyonunu
artırırken, glukagon sekresyonunu baskılar.Glukagon benzeri peptid-1 reseptör agonistleri ve dipeptidil peptidaz-4
inhibitörleri inkretin bazlı tedavilerdir. Glukagon benzeri
peptid-1 reseptör agonistleri önemli tedavilerden olup, monoterapi
veya kombine tedavilerle birlikte kullanılabilmektedir. İyi glisemik
kontrol sağlamalarının yanında hipoglisemi oranların düşük olması
ve kilo kaybına neden olmaları önemli avantajlarıdır. Dipeptidil
peptidaz-4 inhibitörleri; glukagon benzeri peptid-1 ve glukoz ba-
ğımlı insülinotropik polipeptid gibi inkretin hormonların hızlıca inaktivasyonuna
neden olur. DPP-4 inhibitörleri; dolaşımdaki inkretin
hormonların yıkım

Keywords

inkretin; glukagon benzeri peptid-1; dipeptidil peptidaz-4 inhibitörleri

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