Alzheimer Hastalığı Olan Hastalarda Kan MDA, GSH ve Nitrik Oksit Düzeylerinin Araştırılması

Abstract

Amaç: Bu çalışmanın amacı Alzheimer hastalığı (AH) olan hastalarda kan malondialdehit (MDA), redükte Glutatyon (GSH) ve nitrik oksit (NO) seviyelerini belirlemektir. Materyal ve Metot: Çalışmaya Kars’ta yaşayan 65 ve 79 yaşları arasında 15 sağlıklı kişi ve 15 Alzheimer hastası dâhil edildi. Kafkas Üniversitesi Tıp Fakültesi Nöroloji Servisi’nde Alzheimer tanısı konan hastalardan kan örnekleri alınmadan önce Standart Mini Zihinsel Durum Muayenesi (SMMSE) ve Klinik Demans Derecesi uygulandı. Bir sonraki adımda eritrosit GSH ve serum MDA, NO seviyeleri belirlendi. Bulgular: Sağlıklı kişiler ile Alzheimer hasta grubu eritrosit GSH (p<0,05) ve serum MDA (p<0,01), NO (p<0,001) düzeyleri arasındaki fark istatistiksel olarak anlamlı bulundu. MMSE skorları kontrol grubundan anlamlı olarak düşük (p<0,001) bulundu. Sonuç: AH’ın lipid peroksidasyon oluşumuna yol açtığı ve bunun sonucu olarak AH’nın kanındaki MDA, GSH ve NO seviyelerini önemli ölçüde arttırdığı görülmüştür. Bu çalışma AH durumunda beynin artan oksidatif stresden etkilendiği teorisini desteklemektedir.

Keywords

• Alzheimer
• malondialdehit
• glutatyon; lipit peroksidasyonu; nitrik oksit

Investigation of the Levels of Blood MDA, GSH and Nitric Oxide Levels in Patients with Probable Alzheimer’s Disease

Abstract

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