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Halosperm tekniği ile bakılan DNA fragmantasyon oranının IVF-ICSI sonuçları üzerine olan etkisi

Year 2011, Yıl: 2011 Sayı: 3, 92 - 96, 01.11.2011

Mustafa Kara Nurettin Türktekin Turgut Aydın

Abstract

Sperm DNA hasarı erkek infertilitesinin önemli bir sebebidir ve IVF’in bsonuçlarını etkiler. Bu çalışmada DNA fragmantasyon oranının IVF-ICSI sonuçları üzerine etkisini araştırmayı ladık.YöntemToplam 15 hasta çalışmaya dahil edildi. Tedavi protokolünün antagonist ve uzun ortokol olmasına ve DNA fragmantasyonunun %30 v eüstünde ya da %30'un altında olmasına göre hastalar iki ayrı gruplama işlemi sonrası IVF-ICSI sonuçları değerlendirildi.DNA fragmantasyonu halosperm tekniği ile hesaplandıBulgularKarşılaştırma gruplarına göre çalışmada yer alan hastaların infertilite özellikleri benzerdi. Tedavi protokolüne göre kıyaslamada gruplar arası anlamlı farklılık izlenmedi (p> 0,05). DNA fragmantasyon oranına göre kıyaslamada da tedavi sonuçları açısından farklılık izlenmedi (p> 0,05). Fertilizasyon oranı % 29.7 olarak bulundu. Klinik gebelik oranı % 6.6 idi. Spermlerin ortalama DNA fragmantasyon oranı (DFO) 25.2 ± 13.6 idi. SonuçÇalışmamız spermatozoadaki DNA fragmantasyon oranını IVF-ICSI sonuçları ile ilişkisiz bulsa da, daha büyük örneklemle yapılan prospektif randomize kontrollü çalışmaların daha aydınlatıcı olacağını düşünüyoruz.

Keywords

ICSI in vitro fertilizasyon DNA fragmentasyon oranı sperm Halosperm tekniği belirleme

The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes

Year 2011, Yıl: 2011 Sayı: 3, 92 - 96, 01.11.2011

Mustafa Kara Nurettin Türktekin Turgut Aydın

Abstract

AimDamage in sperms DNA is an important cause of male infertility and effects the outcomes of in vitro fertilization. We aimed to study the influence of DNA fragmantation rate on IVF-ICSI outcomes.MethodsA total of fifteen patients were included in the study. The patients were involved in a grouping process according to the treatment protocols of antagonize and long protocols, or according to the DNA fragmantation rate of 30% and more or less than 30%. The outcomes of the IVF-ICSI processes were evaluated by comparison of the groups. DNA framantation rates were demonstrated by using the halosperm technique.ResultsInfertility characteristics of the comparison groups were similar. The comparison according to the treatment protocols did not show significant differences between the outcomes of the treatments (p> 0.05). In addition, comparison according to the spern DNA fragmantation rates also did not show significant differences between treatment outcomes (p> 0.05). The total fertilization rate was 29.7% and the clinical pregnancy rate was 6.6 %. Mean DNA fragmantation rate of the sperms was 25.2 ± 13.6.Conclusion: Although, our study could not demonstrate a correlation between the DNA fragmantation rates of the sperms and the IVF-ICSI outcomes, we think that future prospective randomized controlled trials with larger samples will be more enlightening.

Keywords

ICSI In vitro fertilization DNA fragmentation rate Sperm Halosperm technique determination

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Details

Other ID JA99VR75CS
Journal Section Research Article
Authors

Mustafa Kara This is me

Nurettin Türktekin This is me

Turgut Aydın This is me

Publication Date November 1, 2011
Published in Issue Year 2011 Yıl: 2011 Sayı: 3

Cite

APA Kara, M., Türktekin, N., & Aydın, T. (2011). The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes. Kafkas Journal of Medical Sciences(3), 92-96.
AMA Kara M, Türktekin N, Aydın T. The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes. KAFKAS TIP BİL DERG. November 2011;(3):92-96.
Chicago Kara, Mustafa, Nurettin Türktekin, and Turgut Aydın. “The Effect of DNA Fragmantation Rate Measured by Using Halosperm Technique on IVF-ICSI Outcomes”. Kafkas Journal of Medical Sciences, no. 3 (November 2011): 92-96.
EndNote Kara M, Türktekin N, Aydın T (November 1, 2011) The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes. Kafkas Journal of Medical Sciences 3 92–96.
IEEE M. Kara, N. Türktekin, and T. Aydın, “The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes”, KAFKAS TIP BİL DERG, no. 3, pp. 92–96, November 2011.
ISNAD Kara, Mustafa et al. “The Effect of DNA Fragmantation Rate Measured by Using Halosperm Technique on IVF-ICSI Outcomes”. Kafkas Journal of Medical Sciences 3 (November 2011), 92-96.
JAMA Kara M, Türktekin N, Aydın T. The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes. KAFKAS TIP BİL DERG. 2011;:92–96.
MLA Kara, Mustafa et al. “The Effect of DNA Fragmantation Rate Measured by Using Halosperm Technique on IVF-ICSI Outcomes”. Kafkas Journal of Medical Sciences, no. 3, 2011, pp. 92-96.
Vancouver Kara M, Türktekin N, Aydın T. The effect of DNA fragmantation rate measured by using Halosperm technique on IVF-ICSI outcomes. KAFKAS TIP BİL DERG. 2011(3):92-6.