Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies

Hasan İkbal Atılgan; Gökhan Koca; Koray Demirel; Sinem Özyurt; Şule Yıldırım; Rahime Orak; Aylin Baskın; Meliha Korkmaz

Diferansiyel renal fonksiyon ve renal parankimal defektlerin Tc-99m DMSA ve Tc-99m MAG3 sintigrafileri ile karşılaştırılmalı değerlendirilmesi

Year 2012, Yıl: 2012 Sayı: 2, 43 - 48, 01.07.2012

Hasan İkbal Atılgan Gökhan Koca Koray Demirel Sinem Özyurt Şule Yıldırım Rahime Orak Aylin Baskın Meliha Korkmaz

Abstract

AMAÇ: Tc-99m DMSA sintigrafisi renal parankimal defektlerin saptanması
ve diferansiyel renal fonksiyonun hesaplanmasında güvenilir,
Kafkas J Med Sci 2012; 2(2):43–48 • doi: 10.5505/kjms.2012.21939
duyarlı ve sık tercih edilen bir yöntemdir. Biz çalıșmamızda pediatrik
yaș grubundaki renal hastalıkların değerlendirilmesinde Tc 99m
MAG3 ve Tc 99m DMSA’nın etkinliğini karșılaștırmayı amaçladık.
YÖNTEM: Tc-99m DMSA ile en az bir bölgede renal kortikal hipoaktif
alan, hipoaktif defekt ve/veya renal kortikal uptake’te azalma
olup olmadığı saptandıktan sonra Tc-99m MAG3 ile renal parankim
değerlendirmesi kalitatif ve kantitatif olarak yapıldı. Tc99m DMSA
ile yapılan kalitatif değerlendirmede 206 böbrekteki uyum/uyumsuzluk
değerlendirildi. Tc-99m MAG3 sintigrafisiyle de bașlangıç
renal ekstraksiyon fonksiyonları hesaplandı. Her iki yöntem istatistiksel
olarak değerlendirildi.
BULGULAR: Çalıșmada yaș ortalamaları 8,8±3,2 olan 61(%59) kız
ve 49(%41) erkek yer aldı. Tc-99m DMSA ile böbrek fonksiyonları-
na katkı, sol böbrekte 50,15±21,07 ve sağ böbrekte 49,85±21,08
bulundu. Tc-99m MAG3 ile sol böbreğin katkısı 51,10 ±22,00 ve
sağın katkısı 48,90±22,01 olarak hesaplandı. Her iki grup arasında
pozitif yönde güçlü ilișki bulundu (r=0,990, p=0,001). 155/206
(%75,25) uyumlu ve 51/206 (%24,75) kısmi uyumsuz hipoaktif alan/
defekt veya uptake’ te azalma saptandı.
SONUÇ: Tc-99m DMSA ve Tc-99m MAG3 ile renal fonksiyon de-
ğerlendirmesinde pozitif korelasyonlar saptadık.

Keywords

nükleer tıp, radyoizotop renografi, radyonükleer görüntüleme, technetium Tc 99m dimercaptosuccinic acid, technetium Tc 99m mertiatide

Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies

Year 2012, Yıl: 2012 Sayı: 2, 43 - 48, 01.07.2012

Hasan İkbal Atılgan Gökhan Koca Koray Demirel Sinem Özyurt Şule Yıldırım Rahime Orak Aylin Baskın Meliha Korkmaz

Abstract

AIM: Tc-99m DMSA scintigraphy is a reliable, sensitive and frequently
preferred method in both the detection of renal defects
and the calculation of differential renal function. In this study our
aim was to compare the effi ciency of the Tc 99m MAG3 with the
Tc 99m DMSA in the evaulation of renal parenchymal diseases of
the pediatric age group.
METHODS: Following the determination of at least one hypoactive
region, a hypoactive defect and/or a decrease in renal cortical
uptake in Tc-99m DMSA scan, the renal paranchyma was evaluated
qualitatively and quantitatively by using Tc-99m MAG3 scintigraphy.
By qualitative assessment, compliance/non-compliance
of the 206 kidneys were evaluated. The initial renal extraction functions
were calculated by using the Tc-99m MAG3 scintigraphy.
Both methods were evaluated statistically.
RESULTS: The study included 61(59%) female and 42 (41%) males
with a mean age of 8.8 ±3.2 years. The contributions of the left and
the right kidneys to the total renal function with the Tc-99m DMSA
scintigraphy were as 50.1521.07 and 49.85±21.08, respectively. The
contributions of the initial left and right renal extraction functions with
the Tc-99m MAG3 were as 51.10±22.00 and 48.90±22.01, respectively.
The two scintigraphy techniques were signifi cantly correlated
(r=0.990,p=0.001). There were 155 (75.25%) compliant kidneys and 51
(24.75%) kidneys with hypoactive regions/scars or decreased uptake.
CONCLUSION: There was a positive correlation between the
Tc-m99m DMSA and the the Tc--99m MAG3 reanl functional
assessments

Keywords

nuclear medicine, radioisotope renography, radionucleotide ımaging, technetium Tc 99m dimercaptosuccinic acid, technetium Tc 99m mertiatide

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Details

Other ID	JA43JK45VV
Journal Section	Research Article
Authors	Hasan İkbal Atılgan This is me Gökhan Koca This is me Koray Demirel This is me Sinem Özyurt This is me Şule Yıldırım This is me Rahime Orak This is me Aylin Baskın This is me Meliha Korkmaz This is me
Publication Date	July 1, 2012
Published in Issue	Year 2012 Yıl: 2012 Sayı: 2

Cite

APA	Atılgan, H. İ., Koca, G., Demirel, K., Özyurt, S., et al. (2012). Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies. Kafkas Journal of Medical Sciences(2), 43-48.
AMA	Atılgan Hİ, Koca G, Demirel K, Özyurt S, Yıldırım Ş, Orak R, Baskın A, Korkmaz M. Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies. KAFKAS TIP BİL DERG. July 2012;(2):43-48.
Chicago	Atılgan, Hasan İkbal, Gökhan Koca, Koray Demirel, Sinem Özyurt, Şule Yıldırım, Rahime Orak, Aylin Baskın, and Meliha Korkmaz. “Comparative Evaluation of Differential Renal Functions and Renal Parenchymal Defects by Using the Tc-99m DMSA and Tc-99m MAG3 Scintigraphies”. Kafkas Journal of Medical Sciences, no. 2 (July 2012): 43-48.
EndNote	Atılgan Hİ, Koca G, Demirel K, Özyurt S, Yıldırım Ş, Orak R, Baskın A, Korkmaz M (July 1, 2012) Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies. Kafkas Journal of Medical Sciences 2 43–48.
IEEE	H. İ. Atılgan, G. Koca, K. Demirel, S. Özyurt, Ş. Yıldırım, R. Orak, A. Baskın, and M. Korkmaz, “Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies”, KAFKAS TIP BİL DERG, no. 2, pp. 43–48, July 2012.
ISNAD	Atılgan, Hasan İkbal et al. “Comparative Evaluation of Differential Renal Functions and Renal Parenchymal Defects by Using the Tc-99m DMSA and Tc-99m MAG3 Scintigraphies”. Kafkas Journal of Medical Sciences 2 (July 2012), 43-48.
JAMA	Atılgan Hİ, Koca G, Demirel K, Özyurt S, Yıldırım Ş, Orak R, Baskın A, Korkmaz M. Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies. KAFKAS TIP BİL DERG. 2012;:43–48.
MLA	Atılgan, Hasan İkbal et al. “Comparative Evaluation of Differential Renal Functions and Renal Parenchymal Defects by Using the Tc-99m DMSA and Tc-99m MAG3 Scintigraphies”. Kafkas Journal of Medical Sciences, no. 2, 2012, pp. 43-48.
Vancouver	Atılgan Hİ, Koca G, Demirel K, Özyurt S, Yıldırım Ş, Orak R, Baskın A, Korkmaz M. Comparative evaluation of differential renal functions and renal parenchymal defects by using the Tc-99m DMSA and Tc-99m MAG3 scintigraphies. KAFKAS TIP BİL DERG. 2012(2):43-8.